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Aquaporins in the Eye

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Aquaporins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 969))

Abstract

The major part of the eye consists of water . Continuous movement of water and ions between the ocular compartments and to the systemic circulation is pivotal for many physiological functions in the eye. The movement of water facilitates removal of the many metabolic products of corneal-, ciliary body-, lens- and retinal metabolism, while maintaining transparency in the optical compartments. Transport across the corneal epithelium and endothelium maintains the corneal transparency. Also, aqueous humour is continuously secreted by the epithelia of the ciliary body and maintains the intraocular pressure. In the retina, water is transported into the vitreous body and across the retinal pigment epithelium to regulate the extracellular environment and the hydration of the retina. Aquaporins (AQPs ) take part in the water transport throughout the eye.

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Abbreviations

AQP :

aquaporin

IOP:

intraocular pressure

kDa:

kilodalton

Kir4.1:

inward rectifying potassium channel

MIP:

Major intrinsic protein

mRNA:

messenger ribonucleic acid

RGC:

retinal ganglion cell

RPE:

retinal pigment epithelium

RT-PCR:

reverse transcriptase-polymerase chain reaction

TM:

trabecular meshwork

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Authors and Affiliations

  1. Department of Ophthalmology, Rigshospitalet – Glostrup, University of Copenhagen, Copenhagen, Denmark

    Thuy Linh Tran M.D., Ph.D., Steffen Hamann M.D., Ph.D. & Steffen Heegaard M.D., D.M.Sc.

Authors
  1. Thuy Linh Tran M.D., Ph.D.
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  2. Steffen Hamann M.D., Ph.D.
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  3. Steffen Heegaard M.D., D.M.Sc.
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Corresponding author

Correspondence to Thuy Linh Tran M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Tran, T.L., Hamann, S., Heegaard, S. (2017). Aquaporins in the Eye. In: Yang, B. (eds) Aquaporins. Advances in Experimental Medicine and Biology, vol 969. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1057-0_12

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