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The Discovery of Heat Shock Response System and Major Groups of Heat Shock Proteins

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Heat Shock Proteins and Whole Body Adaptation to Extreme Environments

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Abstract

Drastic changes in the genes expression pattern in response to heat stress were originally demonstrated in Drosophila busckii and D. melanogaster (Ritossa 1962, 1963). Initially, it was shown that in the both species a few new large puffs in the salivary gland chromosomes were formed immediately after heat shock treatment. Specifically, in D. melanogaster the puffs were observed at several chromosomal loci in all large autosomes (33B, 63В, 64В, 67В, 70A, 87A, 87B, 93D and 95C) (Ritossa 1963). These changes in chromosome morphology can be easily seen under a light microscope due to giant size of polythene chromosomes in the larval salivary glands of Drosophila (Fig. 1.1). Only one decade later the main groups of proteins corresponding to the individual heat-induced puffs were identified and called “heat shock proteins” (Hsps) (Ashburner and Bonnert 1979; Lewis et al. 1975; Lewis and Pelham 1985; Tissières et al. 1974).

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, Russia

    Michael B. Evgen’ev, David G. Garbuz & Olga G. Zatsepina

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  1. Michael B. Evgen’ev
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  2. David G. Garbuz
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  3. Olga G. Zatsepina
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Evgen’ev, M.B., Garbuz, D.G., Zatsepina, O.G. (2014). The Discovery of Heat Shock Response System and Major Groups of Heat Shock Proteins. In: Heat Shock Proteins and Whole Body Adaptation to Extreme Environments. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9235-6_1

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