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Tumor Infiltration by Immune Cells: Pathologic Evaluation and a Clinical Significance

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The Tumor Immunoenvironment

Abstract

Tumor infiltrating leukocytes comprise a significant population of cells in the tumor microenvironment. Pathologic evaluation of tumors by methods of light microscopy and immunohistochemistry allow identification of all types of leukocytes, including the cells of myeloid, monocytoid and lymphoid origin. The density of these cells, their spatial distribution in tumor islets and stroma, their level of maturation and functional status vary considerably in the tumors of different nature, grade and stage. By the analysis of clinical data it has been shown that specific types of tumor infiltrating leukocytes have a major impact on the clinical course and the outcome of malignant diseases. This chapter describes an approach used by pathologists to gain insight into morphologic and functional properties of tumor infiltrating leukocytes, as well as their prognostic significance.

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  1. Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh VA Hospital, Pittsburgh, PA, USA

    Dmitriy W. Gutkin

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  1. Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street Scaife Hal, Pittsburgh, 15213, Pennsylvania, USA

    Michael R. Shurin

  2. , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Viktor Umansky

  3. , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Post Office B, Frederick, 21702, Maryland, USA

    Anatoli Malyguine

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Gutkin, D.W. (2013). Tumor Infiltration by Immune Cells: Pathologic Evaluation and a Clinical Significance. In: Shurin, M., Umansky, V., Malyguine, A. (eds) The Tumor Immunoenvironment. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6217-6_3

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