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Novel Hypothesis on Telomere Length: Heterogenic Targets as Genomic/Somatic Diverse Value in Breast Cancer and Brain Tumor

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Telomere Territory and Cancer

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Abstract

Telomere territory is a promising destination and network in cancer research, hosting unmasked facts and insights. Cancer, as a genetic disease is strongly related to the aging and environmental factors. Specifically, breast cancer and brain tumors are noticeable neoplasm’s and seem to be reliable candidates for the future personalized cancer medicine with translational impact. In both tumors, well clarified and appropriate strategy for providing predisposing, early detection, and preventive package is desperately required. Telomere length assay is a reliable choice to characterize the manner of telomeric behavior at genomic- and somatic level which could pave the way towards an early definition, not in the patients, but in their relatives through different generations of their pedigree. This chapter provides evidences supporting a novel hypothesis of telomere length in human breast cancer and brain tumor. The findings rely on the heterogenic patterns at genomic and somatic levels, its interaction with the protein expression involved in cell cycle and proliferation index, by highlighting cellular/molecular evolution and diversity.

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Authors and Affiliations

  1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    P. Mehdipour

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  1. P. Mehdipour
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Correspondence to P. Mehdipour .

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  1. School Of Medicine, Tehran University of Medical Sciences, Department of Medical Genetics, Pour Sina Avenue, Tehran, 1417613151, Iran

    Parvin Mehdipour

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© 2013 Springer Science+Business Media Dordrecht

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Mehdipour, P. (2013). Novel Hypothesis on Telomere Length: Heterogenic Targets as Genomic/Somatic Diverse Value in Breast Cancer and Brain Tumor. In: Mehdipour, P. (eds) Telomere Territory and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4632-9_5

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