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CD33 (Siglec 3) and CD33-Related Siglecs

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Animal Lectins: Form, Function and Clinical Applications

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Abstract

Sialic-acid-binding immunoglobulin-like lectins (Siglecs) bind sialic acids in different linkages in a wide variety of glycoconjugates. These membrane receptors are expressed in a highly specific manner, predominantly within haematopoietic system. Activating and inhibitory receptors act in concert to regulate cellular activation. Second sub-set of rapidly evolving siglecs is designated the CD33-related siglecs. In humans, these include CD33 and siglecs-5, -6, -7 (7/p75/AIRM1), -8, -9, 10, -11, -14 and -16, whereas, in mice, they comprise murine CD33 and siglec-E, -F, -G and -H. CD33 is a myeloid-specific inhibitory receptor, which along with CD33-related Siglecs represent a distinct subgroup that is undergoing rapid evolution. The structural features of CD33-related Siglecs and the frequent presence of conserved cytoplasmic signaling motifs point to their roles in regulating leukocyte functions that are important during inflammatory and immune responses. McMillan and Crocker (2008) reviewed ligand binding preferences and described the functional roles of CD33-related Siglecs in the immune system and the potential for targeting novel therapeutics against these surface receptors. Siglec-4 belonging to subset 1 of sialoadhesin family is discussed in Chap. 16.

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  1. Department of Biophysics, Punjab University, Chandigarh, India

    G. S. Gupta (Former Professor and Chairman)

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Gupta, G.S. (2012). CD33 (Siglec 3) and CD33-Related Siglecs. In: Animal Lectins: Form, Function and Clinical Applications. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1065-2_17

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