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Nichtoperative Therapie der Varikose

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Varikose

Zusammenfassung

Die primäre Varikose ist eine unheilbare Erkrankung. Die Forderung nach einer konsequenten und frühzeitigen Therapie ist zum einen eine Forderung vorausschauender Gesundheitsfürsorge und ärztlicher Ethik und andererseits eine ökonomische Notwendigkeit, da die Spätstadien der dekompensierten Varikose ganz erhebliche Behandlungs- und sonstige Folgekosten verursachen. Nimmt man einmal das therapieresistente Ulcus cruris aus, so ergibt sich bei der Varikose in jedem Stadium immer und ausnahmslos eine Option für die konservative Therapie, welche die gegebenen Beschwerden mehr oder weniger zu lindern imstande ist, die Entwicklung schwerwiegender Spätstadien verhindern kann, aber natürlich Varizen weder zum Verschwinden bringt, noch die immanente Progression der Erkrankung verhindern kann. Dies bedeutet allerdings keineswegs, dass die konservative Therapie in der Hierarchie der Therapieoptionen eine herausragende Stellung einnimmt. Die Frage nach dem Benefit für den betroffenen Patienten ist vor jeder Therapieentscheidung zu stellen und kann je nach Lage der Dinge zu sehr unterschiedlichen Schlussfolgerungen führen.

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Literatur

  • Ahmed M, Reffat SA, Hassan A, Eskander F (2017 Jan) Platelet-Rich plasma for the treatment of clean diabetic foot ulcers. Ann Vasc Surg 38:206–211. https://doi.org/10.1016/j.avsg.2016.04.023 Epub 2016 Aug 12

  • Ainsworth BE, Haskell WL, Leon AS et al (1993) Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25:71–80

    Article  CAS  PubMed  Google Scholar 

  • Araujo D, Gulati O, Osswald W (1985) Effects of two venotropic drugs on inactivation and O-methylation of catecholamines in an isolated canine vein. Arch Int Pharmacodyn Ther 277:192–202

    CAS  PubMed  Google Scholar 

  • Araujo DN et al (2016) Physical exercise for the treatment of non-ulcerated chronic venous insufficiency. Cochrane Database of Systematic Reviews Issue 12. Art. No.: CD010637

    Google Scholar 

  • Augustin M, Ermut T, Johnsen S, Schoepf E, Vanscheidt W, Zschocke I (2001) Effects of autologous keratinocyte transplantation on the quality of life of patients with severe chronic leg ulcers. Dermatol Psychosom 2:73–76

    Article  Google Scholar 

  • AWMF, Leitlinien DGfP (2000) Systematic review of wound care management. Leitlinien DGfP, Diagnostik und Therapie des Ulcus cruris venosum. Health Technol Assess 4(21)

    Google Scholar 

  • Aziz Z, Tang WL, Chong NJ, Tho LY (2015) A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther 40:177–185

    Article  CAS  PubMed  Google Scholar 

  • Belcaro G, Dugall M, Luzzi R, Corsi M, Ledda A, Ricci A, Pellegrini L, Cesarone MR, Hosoi M, Errichi BM, Cornelli U, Cotellese R, Agus G, Feragalli B (2017) Management of Varicose Veins and Chronic Venous insufficiency in a comparative registry with nine venoactive products in comparison with stockings. Int J Angiol 26:170–178

    Article  CAS  PubMed  Google Scholar 

  • Bergstein NA (1975) Clinical study on the efficacy of O-(beta-hydroxyethyl)rutoside (HR) in varicosis of pregnancy. J Int Med Res 3:189–193

    Article  CAS  PubMed  Google Scholar 

  • Blättler W, Thoma HJ, Amsler WC, F (2016) Light medical compression stockings reduce symptoms when standing equally as firm ones. Phlebologie 45:25–28

    Article  Google Scholar 

  • Bolliger A (1964) Die Bedeutung der physikalischen Therapie in der Phlebologie. Zentralbl Phlebol 3:129–135

    CAS  PubMed  Google Scholar 

  • Borg GAV (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14:377–381

    Article  CAS  PubMed  Google Scholar 

  • Bringezu G, Schreiner O (2014) Lehrbuch der Entstauungstherapie, 4. Aufl. Springer, Heidelberg

    Google Scholar 

  • Brock FE (1994) Hydrotherapie bei chronischen Venenerkrankungen. In: Pratzel HG (Hrsg), Health Resort Medicine, ISMH Verlag Geretsried, S. 409

    Google Scholar 

  • Bulling B (1995) Die Medi-Venenschlinge – Ein Hilfsmittel zur Therapie des arthrogenen Stauungssyndroms bei chronisch venöser Insuffizienz. Vasomed 4:46–47

    Google Scholar 

  • Cartier CJ (1999) Mercury bath compression. In: Gardon-Mollard C, Ramelet AA (Hrsg) Compression therapy. Masson, Paris

    Google Scholar 

  • Cloarec M, Clement R, Griton P (1996) A double-blind clinical trial of hydroxyethylrutosides in the treatment of the symptoms and signs of chronic venous insufficiency. Phlebology 11:76–82

    Article  Google Scholar 

  • Cordes JC (1980) Handbuch der Physiotherapie. Media Press Zürich 1(1):82

    Google Scholar 

  • Craig AB, Dvorak M (1966) Thermal regulation during water immersion. Appl Physiol 21:1577–1585

    Article  Google Scholar 

  • Diebolt M, Bucher B, Andriantsitohaina R (2001) Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. Hypertension 38:159–165

    Article  CAS  PubMed  Google Scholar 

  • Diehm C et al (2002) Get ABI: German epidemiological trial on ankle brachial index for elderly patients in family practice to dedect peripheral arterial disease, significant marker for high mortality. VASA J Vasc Dis 31:241–248

    Google Scholar 

  • Diehm C, Trampisch HJ, Lange S, Schmidt C (1996) Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 347:292–294

    Article  CAS  PubMed  Google Scholar 

  • Domanski D, Zegrocka-Stendel O, Perzanowska A, Dutkiewicz M, Kowalewska M, Grabowska I, Maciejko D, Fogtman A, Dadlez M, Koziak K (2016) Molecular mechanism for cellular response to β-escin and Its therapeutic implications. PLoS ONE 11:1–18

    Article  CAS  Google Scholar 

  • Erlund I, Kosonen T, Alfthan G, Mäenpää J, Perttunen K, Kenraali J, Parantainen J, Aro A (2000) Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 56:545–553

    Article  CAS  PubMed  Google Scholar 

  • Ernst E, Pittler MH (1998) Wie effektiv ist die Kur? Eine systematische Übersicht randomisierter Studien. Dtsch med Wschr 123:273–277

    Article  CAS  PubMed  Google Scholar 

  • Ernst E, Saradeth T, Resch KL (1991) A single blind, randomized controlled trial of hydrotherapy for varicose veins. VASA 20:147–152

    CAS  PubMed  Google Scholar 

  • Ernst E, Saradeth T, Resch KL (1992) Hydrotherapy for varicose veins. Phlebology 7:154–157

    Article  Google Scholar 

  • Facino RM, Carini M, Stefani R, Aldini G, Saibene L (1995) Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Arch Pharm 328:720–724

    Article  CAS  Google Scholar 

  • Falanga VJ (2000) Tissue engineering in wound repair. Adv Skin Wound Care 13:15–19

    CAS  PubMed  Google Scholar 

  • Felixsson E, Persson IAL, Eriksson AC, Persson K (2010) Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT2A receptors: an in vitro study. Phytother Res 24:1297–1301

    Article  CAS  PubMed  Google Scholar 

  • Friederich HC, Vogelsberg H, Neiss A (1978) Ein Beitrag zur Bewertung von intern wirksamen Venenpharmaka. Zschr Hautkrankh 53:369–374

    CAS  Google Scholar 

  • Gallasch G, Dorfer C, Schmitt T, Stage A (1985) Wirksamkeit von Troxerutin auf die Fließeigenschaften des Blutes unter definierten Strömungsbedingungen. Klin Mbl Augenheilkd 87:30–35

    Article  Google Scholar 

  • Ganeshpurkar A, Saluja AK (2017) The Pharmacological potential of Rutin. Saudi Pharm J 25:149–164

    Article  PubMed  Google Scholar 

  • Garreau C, Garreau-Gomez B (1983) Mesures des effets des eaux de Barbaton les-Thermes sur le remplissage et la vidange veneuse chez les phlébitiques et les variqeux par pléthysmografie à jauge de mésure. Phlebologie 38:59–39

    Google Scholar 

  • Grau M, Bölck B, Bizjak DA, Stabenow CJA, Bloch W (2016) The red-vine-leaf extract AS195 increases nitric oxide synthase–dependent nitric oxide generation and decreases oxidative stress in endothelial and red blood cells. Pharma Res Per 4:1–13

    Google Scholar 

  • Häfner HM, Eichner M, Jünger M (2001a) Medizinische Kompressionstherapie. Zentralbl Chir 126:551–556

    Article  PubMed  Google Scholar 

  • Häfner HM, Piche E, Jünger M (2001b) The ratio of working pressure to resting pressure under compression stockings: its significance for the improvement of venous perfusion in the legs. Phlebologie 30:88–93

    Article  Google Scholar 

  • Hänsel R, Keller K, Rimpler H, Schneider G (1992) Hagers Handbuch der pharmazeutischen Praxis, Drogen A-D, 5. Aufl. Springer, Berlin, S. 108–22

    Google Scholar 

  • Hartmann B, Agishi Y, Yorozu H et al (1990) Results of the consensus-finding conference on carbon dioxide. Z Phys Med Baln Med Klims 19(suppl):11–12

    Google Scholar 

  • Hartmann B, Drews B, Kayser T (1997) Physical therapy improves venous hemodynamics in cases of primary varicosity: results of a controlled study. Angiology 48(2):157–162

    Article  CAS  PubMed  Google Scholar 

  • Hartmann B, Hartmann M, Strass D (2007a) Wirkfaktoren Temperatur und hydrostatischer Druck In: Rehn H, Strass D (Hrsg) Bewegungsraum Wasser im Spannungsfeld zwischen Theorie und Praxis, Bad Nenndorf, S. 86–102

    Google Scholar 

  • Hartmann B, Hartmann M, Strass D. (2007b). Pharmakologie chemischer Inhaltsstoffe von Heilwässern als evidente Therapie und für die Gesundheit. In: Rehn H, Strass D (Hrsg) Bewegungsraum Wasser im Spannungsfeld zwischen Theorie und Praxis, Bad Nenndorf, S 103–113

    Google Scholar 

  • Hartmann BR (1989) Unterschenkel-Hauttemperatur nach Ganzkörper-Immersion in Mineral-Thermalwasser von 34°C. In: Davy A, Stemmer R (Hrsg) Phlebologie, 89, Libbey, London, S. 91

    Google Scholar 

  • Hartmann BR, Drews B, Bassenge E (1998) Venous function in patients with venous disease and healthy controls before and after a bathing procedure and subsequent cold stimulus. Int J Angiology 7:252–254

    Article  CAS  Google Scholar 

  • Hellberg K, Ruschewski W, de Vivie R (1975) Drug induced acute renal failure after heart surgery. Thoraxchir Vask Chir 23:396–399

    CAS  PubMed  Google Scholar 

  • Heyer K, Augustin M, Protz K, Herberger K, Spehr C, Rustenbach SJ (2013) Effectiveness of advanced versus conventional wound dressings on healing of chronic Wounds: Systematic Review and Meta-Analysis. Dermatology 226:172–184

    CAS  Google Scholar 

  • HMPC (2008) Committee of Herbal Medicinal Products (HMPC). Assessment report on aesculus hippocastanum l. semen (EMEA/HMPC/225304/2008). https://www.ema.europa.eu/documents/herbal-report/assessment-report-aesculus-hippocastanum-l-semen_en.pdf. Zugegriffen: 2. Jan. 2019

  • HMPC (2016) Committee on Herbal Medicinal Products (HMPC), European Medicines Agency (EMA). Assessment report on Vitis vinifera L., folium (EMA/HMPC/464682/2016). https://www.ema.europa.eu/documents/herbal-opinion/opinion-hmpc-european-union-herbal-monograph-vitis-vinifera-l-folium-first-version_en.pdf. Zugegriffen: 1. Jan. 2019

  • HMPC (2017) Committee on Herbal Medicinal Products (HMPC), European Medicines Agency (EMA). Opinion of the HMPC on a European Union herbal monograph on Vitis vinifera L., folium (EMA/HMPC/338763/2017). https://www.ema.europa.eu/documents/herbal-opinion/opinion-hmpc-european-union-herbal-monograph-vitis-vinifera-l-folium-first-version_en.pdf. Zugegriffen: 1. Jan. 2019

  • Hohlbaum GG (1987) Zur Geschichte der Kompressionstherapie (I). Phlebol Proktol 16:241–255

    Google Scholar 

  • Hohlbaum GG (1988) Zur Geschichte der Kompressionstherapie (II). Phlebol Proktol 17:24–37

    Google Scholar 

  • Hughes OB, Rakosi A, Macquhae F, Herskovitz I, Fox JD, Kirsner RS (2016) A review of cellular and acellular matrix products: indications, techniques, and outcomes. Plast Reconstr Surg 2016 Sep;138(3 Suppl):138–47S. https://doi.org/10.1097/PRS.0000000000002643

  • Incandela L, Belcaro G, Renton S, DeSanctis MT, Cesarone MR, Bavera P, Ippolito E, Bucci M, Griffin M, Geroulakos G, Dugall M, Golden G, Acerbi G (2002) Treatment of diabetic microangiopathy and edema with HR (Paroven, Venoruton; O-(-droxyethyl)-rutosides): a prospective, placebo-controlled, randomized study. J Cardiovasc Pharmacol Therapeut 7(Suppl):7–10

    Article  CAS  Google Scholar 

  • Jordan VH (1985) Bädertherapie. Z Physiother 37:75–98

    Google Scholar 

  • Kalogeromitros DC, Makris MP, Gregoriou SG, Mousatou VG, Lyris NG, Tarassi KE, Papasteriades CA, (2005) Grape anaphylaxis: a study of 11 adult onset cases. Allergy Asthma Proc 26:53–58

    Google Scholar 

  • Kalus U, Koscielny J, Grigorov A, Schaefer E, Peil H, Kiesewetter H (2004) Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R D 5:63–71

    Article  CAS  PubMed  Google Scholar 

  • Kauss T, Moynet D, Rambert J, Al-Kharrat A, Brajot S, Thiolat D, Ennemany R, Fawaz F, Mossalayi MD (2008) Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. Arthritis Res Ther 10:R19

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kiesewetter H, Koscielny J, Kalus U, Vix J-M, Peil H, Petrini O, van Toor BSJ, de Mey C (2000) Efficacy of orally administered extract of red vine leaf AS195 (folia Vitis viniferae) in chronic venous insufficiency (stages l-ll). Arzneimittelforschung 50:109–117

    CAS  PubMed  Google Scholar 

  • Kiesewetter H (2002) Good clinical practice in accordance with clinical studies on the efficacy and tolerability of red wine leaf extract AS195 in chronic venous insufficiency. Vasomed 14:18–20

    Google Scholar 

  • Kiev J et al (1990) Patient compliance with fitted compression hosiery monitored by photoplethysmography. Arch Phys Med Rehabil 71:376–379

    CAS  PubMed  Google Scholar 

  • Klyscz T et al (1994) Diagnostische Methoden zur Beurteilung der kutanen Mikrozirkulation bei der chronischen Veneninsuffizienz. Phlebologie 23:141–145

    Google Scholar 

  • Klyscz T et al (1995) Neuartiges Pedalergometriegerät zur aktiven Bewegungstherapie bei Patienten mit peripheren arteriellen und venösen Zirkulationsstörungen. Phlebologie 24:176–180

    Google Scholar 

  • Klyscz T et al (1997a) Biomechanische Stimulationstherapie (BMS) zur physikalischen Behandlung des arthrogenen Stauungssyndroms. Hautarzt 48:318–322

    Article  CAS  PubMed  Google Scholar 

  • Klyscz T et al (1997b) Gefäßsport zur ambulanten Therapie venöser Durchblutungsstörungen der Beine. Hautarzt 6:384–390

    Article  Google Scholar 

  • Klyscz T, Jünger M (1999) Venenfitness Übungen zur Behandlung und Vorbeugung. Falken Niedernhausen

    Google Scholar 

  • Klyscz T, Jünger M, Rassner G (1999) Physical Therapy of the Ankle Joint in Patients with Chronic Venous Incompetence and Arthrogenic Congestive Syndrome. In: Hafner J, Ramelet A-A, Schmeller W, Brunner UV (Hrsg) Management of Leg Ulcers.Curr Probl Dermatol. Basel, Karger, 27, 141–147

    Google Scholar 

  • Langer C, Schmidbauer U (1993) Das primäre arthrogene Stauungssyndrom. Phlebologie 22:280–281

    Google Scholar 

  • Leach MJ, Pincombe J, Foster G (2006) Clinical efficacy of horse chestnut seed extract in the treatment of venous ulceration. J Wound Care 15:159–167

    Article  CAS  PubMed  Google Scholar 

  • Liu F, Xu Y, Rui L, Gao S, Dong H, Guo Q. (2006) Liquid chromatography/tandem mass spectrometry assay for the quantification of troxerutin in human plasma. Rapid Commun Mass Spectrom 20:3522–3526

    Google Scholar 

  • Lohr E, Garanin G, Jesau P, Fischer H (1986) Ödempräventive Therapie bei chronischer Veneninsuffizienz mit Ödemneigung. Münchener Med Wschr 128:579–581

    Google Scholar 

  • Maeda M, Hayashi H, Yokoka M (2003) The effects of high concentration artifical CO2-WarmWater Bathing for Arterioslerotic Obstruction (ASO). J Jpn Balneol Climatol Phys Med 66:157–163

    Google Scholar 

  • Manach C, Donovan JL (2004) Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radical Res 38(8):771–785

    Article  CAS  Google Scholar 

  • Mancini S, Piccinetti A, Nappi G, Mancini S, Caniato A, Cocchieri S (2003) Clinical, functional and quality of life changes after balneokinesis with sulphurous water in patients with varicose veins. VASA 32:26–30

    PubMed  Google Scholar 

  • Martinez-Zapata MJ, Vernooij RWM, Uriona Tuma SM, Stein AT, Moreno RM, Vargas E, Capella D, Bonfill Cosp X (2016) Phlebotonics for venous insufficiency. Cochrane Database of Syst Rev 4: Art. No. CD003229

    Google Scholar 

  • Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L, Garcia J, Zaror C. (2016) Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev 2016 May 25;(5):CD006899. https://doi.org/10.1002/14651858.CD006899.pub3

  • Meuche S (2009) Flüssigkeitshaushalt unter besonderer Berücksichtigung der Flüssigkeitsbilanzen und NT-proBNP vor, während und nach thermoneutraler Immersion. Charité-Universitätsmedizin Berlin, Med. Diss

    Google Scholar 

  • Middleton E Jr, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673–751

    CAS  PubMed  Google Scholar 

  • Morales Paris CA, Barros Soares RM (1993) Efficacy and safety on use of dried horse chestnut extract in the treatment of chronic venous insufficiency of the limbs. Rev Bras Med 50:1563–1565

    Google Scholar 

  • Morling JR, Broderick C, Yeoh SE, Kolbach DN (2018) Rutosides for treatment of post-thrombotic syndrome. Cochrane Database Syst Rev 11. Art. No.: CD005625

    Google Scholar 

  • Mosti G (2014) Compression treatment in venous insufficiency and arterial disease. Phlebologie 43:127–133

    Article  Google Scholar 

  • Mosti G, Partsch H (2010) Is low compression pressure able to improve venous pumping function in patients with venous insufficiency? Phlebology 25:145–150

    Article  CAS  PubMed  Google Scholar 

  • Mutlak O, Aslam M, Nigel Standfield N (2018) The influence of exercise on ulcer healing in patients with chronic venous insufficiency. Int Angiol 37(2):160–168

    Article  PubMed  Google Scholar 

  • Nees S, Weiss DR, Reichenbach-Klinke E, Rampp F, Heilmeier B, Kanbach J, Esperester A (2003) Protective effects of flavonoids contained in the red vine leaf on venular endothelium against the attack of activated blood components in vitro. Arzneimittelforsch 53:330–341

    CAS  PubMed  Google Scholar 

  • Neiss A, Böhm C (1976) Zum Wirksamkeitsnachweis von Roßkastaniensamenextrakt beim varikösen Symptomenkomplex. Münchener Med Wschr 118:213–216

    CAS  Google Scholar 

  • Noppeney T, Nüllen H (2011) Neueste Ergebnisse der endovenösen thermischen Verfahren in der Behandlung der Varikose. Gefässchirurgie 16:242ff

    Google Scholar 

  • Padberg FT, Johnston MV, Sisto SA (2007) Structured exercise improves calf muscle pump function in chronic venous insufficiency: a randomized trial. J Vasc Surg 39:79–87

    Article  Google Scholar 

  • Partsch B, Partsch H (2005) Calf Compression pressure required ti achieve venous closure from supine to standing positions. J Vasc Surg 42:734–738

    Article  PubMed  Google Scholar 

  • Partsch H (2010) Primary varicose veins. Compression therapy. Phlebologie 39:133–137

    Article  Google Scholar 

  • Partsch H, Clark M, Bassez S et al (2006) Measurement of lower leg compression in vivo: Recommendations fort he performance of measurements of interface pressure and stiffness. Dermatol Surg 32:229–238

    Google Scholar 

  • Partsch H, Rabe E, Stemmer R (1999) Kompressionstherapie der Extremitäten. Editions Phlebologiques Francaises, Paris (ISBN 2.85480.770.7)

    Google Scholar 

  • Petridou M (1993) Ein standardisiertes Thermalbad von 33–35°C bessert die Venenfunktion in einer kontrollierten Studie. Albert-Ludwigs-Universität Freiburg, Med. Diss

    Google Scholar 

  • Petruzzellis V, Troccoli T, Candiani C, Guarisco R, Lospalluti M, Belcaro G, Dugall M (2002) Oxerutins (Venoruton): Efficacy in chronic venous insufficiency-a double-blind, randomized, controlled study. Angiology 53:257–263

    Article  PubMed  Google Scholar 

  • Pinna C, Morazzoni P, Sala A (2017) Proanthocyanidins from Vitis vinifera inhibit oxidative stress-induced vascular impairment in pulmonary arteries from diabetic rats. Phytomedicine 25:39–44

    Article  CAS  PubMed  Google Scholar 

  • Pittler MH, Ernst E (2012) Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev 11. Art. No.: CD003230

    Google Scholar 

  • Pittler MH, Hartmann BR, Abbot C (1998) Effects of single and serial water immersion on venous function. Perfusion 11:132–136

    Google Scholar 

  • Pratzel HH, Rimpler M, Kimmel U (1995) Medizinische Bäder, Aufbereitungsmonografien und Aufbereitungsmuster für den humanmedizinischen Bereich I. S.M.H, Geretsried

    Google Scholar 

  • Pratzel HH, Schnizer W (1992) Handbuch der Medizinischen Bäder, Indikationen – Anwendungen – Wirkungen, Haug, Heidelberg

    Google Scholar 

  • Rabe E, Partsch H, Hafner J, Lattimer C, Mosti G, Neumann M, Urbanek T, Huebner M, Gaullard S, Carpentier P (2018) Indications for medical compression stockings in venous and lymphatic disorders: an evidence-based consensus statement. Phlebology 33:163–184

    Article  PubMed  Google Scholar 

  • Rabe E, Stücker M, Esperester A, Schäfer E, Ottillinger B (2011) Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency – results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg 41:540–547

    Article  CAS  PubMed  Google Scholar 

  • Raffetto JD, Khalil RA (2011) Ca2+-dependent contraction by the saponoside escin in rat vena cava. Implications in venotonic treatment of varicose veins. Vasc Surg 54: 489–96

    Google Scholar 

  • Rastel D (2015) Compliance für Medizinische Kompressionsstrümpfe bei Patienten mit unkomplizierter Varikose. Vasomed 27:313–314

    Google Scholar 

  • Rehn D, Unkauf M, Klein P, Jost V, Lücker PW (1996) Vergleich der klinischen Wirksamkeit und Verträglichkeit von Oxerutin und Rosskastanienextrakt bei Patienten mit chronischer venöser Insuffizienz. Arzneimittelforsch 46:483–487

    CAS  PubMed  Google Scholar 

  • Schwahn-Schreiber et al. (2018) S1-Leitlinie 037 – 007:(2018–2023) Intermittierende pneumatische Kompression (IPK, AIK). https://www.awmf.org/leitlinien/detail/ll/037-007.html

  • Samson RH (1996) Stockings in the prevention of recurrent venous ulcers. Dermatol Surg 22:373–376

    Article  CAS  PubMed  Google Scholar 

  • Schmeller W (1990) Das arthrogene Stauungssysndrom. Sprunggelenksveränderungen bei chronischer Veneninsuffizienz. Diesbach, Berlin

    Google Scholar 

  • Schmeller W, Gaber Y (2000) Surgical removal of ulcer and lipodermatosclerosis followed by split-skin grafting (shave therapy) yields good long-term results in „non-healing“ venous leg ulcers. Acta Derm Venereol 80:267–271

    Article  CAS  PubMed  Google Scholar 

  • Schmidt K, Debus ES, Jessberger S, Ziegler UE, Thiede A (2000) Bacterial population of chronic crural ulcers: is there a difference between the diabetic, the venous, and the arterial ulcer? VASA 29:62–70

    Article  CAS  PubMed  Google Scholar 

  • Shastry CS, Ashok K, Aravind MB, Joshi SD (2002) Diuretic activity of the extracts of Vitis vinifera leaves. Indian Drugs 39:497–499

    Google Scholar 

  • Sheu J-R, Hsiao G, Chou P-H, Shen M-Y, Chou D-S (2004) Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. J Agric Food Chem 52:4414–4418

    Article  CAS  PubMed  Google Scholar 

  • Sippel K, Jünger M (2006) Kompressionstherapie bei Varikose und chronisch-venöser Insuffizienz. Gefäßchirurgie 11:203–216

    Article  Google Scholar 

  • Sippel K, Seifert B, Hafner J (2015) Donning devices (foot slips and frames) enable elderly people with severe chronic venous insufficiency to put on compression stockings, Eur J Vasc Endovasc Surg

    Google Scholar 

  • Sparsa A, Lesaux N, Kessler E, Bonnetblanc JM, Blaise S, Lebrun-Ly V, Colombeau P, Vidal E, Bédane C (2005) Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shock wave lithotripsy. J Am Acad Dermatol 53(5 Suppl 1):263–265

    Article  PubMed  Google Scholar 

  • Steiner M, Hillemanns HG (1990) Venostasin retard in the management of venous problems during pregnancy. Phlebology 5:41–44

    Article  Google Scholar 

  • Stemmer R (1984) Konzentrische und exzentrische Kompression. Phlebol Proktol 13:53–57

    Google Scholar 

  • Strass D, Hahn A (2009) Biomechanik des Schwimmens. In: Gollhofer A, Müller E (Hrsg) Handbuch Sportbiomechanik. Hofmann, Schorndorf, S 364–389

    Google Scholar 

  • Strölin A, Jünger M (2004) Möglichkeiten der physikalischen Therapie bei Venenerkrankungen. Phlebologie 6:204–210

    Google Scholar 

  • Surhoff S (2014) Compression therapy in sport. Phlebologie 43:137–139

    Article  Google Scholar 

  • Tan J, Abisi S, Smith A, Burnard KG (2007) A painless method of ultrasonically assisted debridement of chronic leg ulcers: a pilot study. Eur J Vasc Endovasc Surg 33:234–238

    Google Scholar 

  • Uhlemann C, Heinig B, Wollina U (2003) Therapeutic ultrasound in lower extremity wound management. Int J Low Extrem Wounds 2:152–157

    Google Scholar 

  • Tschopp M, Pometta D, Babel J (1970) Diabetic retinopathy: study of the action of 0-betahydroxyethyl-rutosides (HR) by retinal fluoresceinography. Diabetologia 6:475–481

    Article  CAS  PubMed  Google Scholar 

  • Ugusman A, Zakaria Z, Chua KH, Nordin NAMM, Mahdy ZA (2014) Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells. Sci World J, Article ID 169370

    Google Scholar 

  • Vanscheidt W, Jost V, Wolna P, Lücker PW, Müller A, Theurer C, Patz B, Grützner KI (2002) Efficacy and safety of a Butcher’s broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency. Arzneimittelforschung 52:243–50

    Google Scholar 

  • Waldhausen P et al (1990) Ambulante Bewegungstherapie in einer Gefäßsportgruppe. In: Diehm C, Gerlach HE (Hrsg) Bewegungstherapie bei peripheren arteriellen Durchblutungsstörungen. Zuckschwert, München

    Google Scholar 

  • Wall R, Lips O, Seibt R, Rieger MA, Steinhilber B (2017) Intra- and inter-rater reliability of lower leg waterplethysmography, bioelectrical impedance and muscle twitch force for the use in standing work evaluation. Physiol Meas 38:701–714

    Article  PubMed  Google Scholar 

  • Watanabe S, Imanishi N, Ishizawa T, Yano S, Takeda S, Miyamoto K, Aburad M, Liyama J, Kawahira K (2006) The effects of bathing with inorganic salts and carbon dioxide on body temperature, systemic circulation, and food ingestion and absorption. J Jpn Balneol Climatol Phy Med 69:167–178

    Google Scholar 

  • Weidinger P (1989) Kompressionsstrumpf – Hilfe oder Trauma – Patientenstatistik. In: Denk, van D (Hrsg) Therapie der Venenerkrankungen. TM, Hameln, S 131–314

    Google Scholar 

  • Weiss T, Elsässer H, Victor C, Hsu E, Diehm C (1991) Akute Auswirkungen einer speziellen Wassergymnastik auf das venöse System bei Patienten mit chronisch venöser Insuffizienz. VASA 20(Suppl):227

    Google Scholar 

  • Werner E (2001) Sporttherapie mit präventiven Venensportgruppen am Wohnort. Dissertation, Heidelberg

    Google Scholar 

  • Werner I, Guo F, Kiessling AH, Juengel E, Relja B, Lamm P, Stock UA, Moritz A, Beiras-Fernandez A (2015) Treatment of endothelial cell with flavonoids modulates transendothelial leukocyte migration. Phlebology 30:405–411

    Article  PubMed  Google Scholar 

  • Wienert V (1999) Die medizinische Kompressionstherapie. Blackwell Wissenschafts-Verlag, Berlin

    Google Scholar 

  • Zelen CM, Orgill DP, Serena T, Galiano R, Carter MJ, DiDomenico LA, Keller J, Kaufman J, Li WW (2017 Apr) A prospective, randomised, controlled, multicentre clinical trial examining healing rates, safety and cost to closure of an acellular reticular allogenic human dermis versus standard of care in the treatment of chronic diabetic foot ulcers. Int Wound J 14(2):307–315. https://doi.org/10.1111/iwj.12600 Epub 2016 Apr 12

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Nüllen, H. et al. (2022). Nichtoperative Therapie der Varikose. In: Noppeney, T., Nüllen, H. (eds) Varikose. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59117-8_20

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