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Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics

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Advances in Nanotheranostics I

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 6))

Abstract

In the past decade, great advances have been achieved for the biomedical application of gold (Au) nanostructures. Due to their unique physicochemical properties, Au nanostructures have been extensively explored for their use in cancer cell imaging, photothermal therapy, as well as drug/gene delivery. The facile control of synthesis and surface functionalization help the construction of multifunctional Au nanostructures for cancer diagnosis and treatment. Recently, Au nanostructure-based theranostic platforms have been extensively explored, and great advantages have been demonstrated. This chapter summarizes the recent progress of Au nanostructures as contrast agents for cancer imaging, as therapeutic composites for photothermal therapy and drug/gene delivery, and as multifunctional theranostic platform for cancer. The surface functionalization of Au nanostructures including noncovalent and covalent modification will also be discussed. We focus on the near-infrared (NIR) light-mediated cancer theranostics using Au nanostructures including Au nanoshells (AuNSs), Au nanorods (AuNRs), hollow Au nanospheres (HAuNSs), and Au nanocages (AuNCs).

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Acknowledgment

This work was supported by grants from the National Basic Research Program of China (973 Programs 2011CB933401 and 2012CB934003), National Major Scientific Instruments Development Project (2011YQ03013406), the National Natural Science Foundation of China (21320102003, 11205166) International Science & Technology Cooperation Program of MOST (2013DFG32340), and the National Science Fund for Distinguished Young Scholars (11425520).

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  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China

    Liming Wang

  2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China

    Yingying Xu & Chunying Chen

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  1. Liming Wang
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  2. Yingying Xu
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Correspondence to Chunying Chen .

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  1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China

    Zhifei Dai

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Wang, L., Xu, Y., Chen, C. (2016). Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics. In: Dai, Z. (eds) Advances in Nanotheranostics I. Springer Series in Biomaterials Science and Engineering, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48544-6_1

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