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Organmykosen

DGIM Innere Medizin

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Organmykosen oder invasive Pilzinfektionen sind eine große und sehr heterogene Gruppe von Infektionen. Im Wesentlichen können zwei Subgruppen unterschieden werden: Infektionen durch primär pathogene Pilze und Infektionen durch fakultativ pathogene Pilze. Während in Europa die Infektionen durch primär pathogene Pilze selten sind und es sich hierbei meist um importierte Fälle handelt, haben invasive Pilzinfektionen insgesamt deutlich zugenommen. Sie stellen bei Intensivpatienten und insbesondere bei hämatologischen und onkologischen Patienten eine wichtige Komplikation dar, die weitreichenden Einfluss auf Morbidität, Mortalität, Dauer des Krankenhausaufenthaltes und nicht zuletzt auf die Kosten für Diagnostik und Therapie hat. In diesem Kapitel werden vor allem die häufigen invasiven Organmykosen dargestellt, die auf Aspergillus spp., Candida spp., Mucorales/Zygomyceten, Cryptococcus spp. sowie Pneumocystis spp. zurückzuführen sind.

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Literatur

  • Aguado JM, Vázquez L, Fernández-Ruiz M, Villaescusa T, Ruiz-Camps I, Barba P, Silva JT, Batlle M, Solano C, Gallardo D, Heras I, Polo M, Varela R, Vallejo C, Olave T, López-Jiménez J, Rovira M, Parody R, Cuenca-Estrella M, for the PCRAGA Study Group the Spanish Stem Cell Transplantation Group, the Study Group of Medical Mycology of the Spanish Society of Clinical Microbiology and Infectious Diseases, and the Spanish Network for Research in Infectious Diseases (2015) Serum galactomannan versus a combination of galactomannan and polymerase chain reaction-based aspergillus DNA detection for early therapy of invasive aspergillosis in high-risk hematological patients: a randomized controlled trial (2015 Feb 01). Clin Infect Dis. 60(3):405–414. https://doi.org/10.1093/cid/ciu833. Epub 2014 Oct 21. PMID: 25336623

  • AWMF-Register Nr. 082/005 S1 Leitlinie Diagnose und Therapie von Candida InfektionenFertigstellung: Dezember 2010 Erste Überarbeitung: Juli 2016 Zweite, aktuelle Überarbeitung: Juli 2020

    Google Scholar 

  • Barragan NC, Sorvillo F, Kuo T (2014) Cryptococcosis-related deaths and associated medical conditions in the United States, 2000–2010. Mycoses. https://doi.org/10.1111/myc.12238. [Epub ahead of print]

  • Bassetti M, Giacobbe DR, Grecchi C, Rebuffi C, Zuccaro V, Scudeller L, FUNDICU investigators (2020) Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: a systematic review with qualitative evidence synthesis. J Infect 81(1):131–146. https://doi.org/10.1016/j.jinf.2020.03.065. Epub 2020 Apr 21. PMID: 32330523

    Article  CAS  PubMed  Google Scholar 

  • Bidaud AL, Chowdhary A, Dannaoui E (2018) Candida auris: an emerging drug resistant yeast – a mini-review. J Mycol Med 28(3):568–573. https://doi.org/10.1016/j.mycmed.2018.06.007. Epub 2018 Jul 17. PMID: 30030072

    Article  CAS  PubMed  Google Scholar 

  • Centers for Disease Control and Prevention (CDC), National Institutes of Health (NIH), and the HIV Medicine Association (HIVMA) of the Infectious Diseases Society of America (IDSA) (2016) Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV – Cryptococcosis (2016, reviewed 2019)

    Google Scholar 

  • Christopeit M, Schmidt-Hieber M, Sprute R, Buchheidt D, Hentrich M, Karthaus M, Penack O, Ruhnke M, Weissinger F, Cornely OA, Maschmeyer G (2020) Prophylaxis, diagnosis and therapy of infections in patients undergoing high-dose chemotherapy and autologous haematopoietic stem cell transplantation. 2020 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol:1–16. https://doi.org/10.1007/s00277-020-04297-8. Epub ahead of print. PMID:33079221; PMCID: PMC7572248

  • Cornely OA, Arikan-Akdagli S, Dannaoui E, Groll AH, Lagrou K, Chakrabarti A, Lanternier F, Pagano L, Skiada A, Akova M, Arendrup MC, Boekhout T, Chowdhary A, Cuenca-Estrella M, Freiberger T, Guinea J, Guarro J, de Hoog S, Hope W, Johnson E, Kathuria S, Lackner M, Lass-Flörl C, Lortholary O, Meis JF, Meletiadis J, Muñoz P, Richardson M, Roilides E, Tortorano AM, Ullmann AJ, van Diepeningen A, Verweij P, Petrikkos G, European Society of Clinical Microbiology and Infectious Diseases Fungal Infection Study Group, European Confederation of Medical Mycology (2014) ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013 (2014 Apr). Clin Microbiol Infect 20(Suppl 3):5–26. https://doi.org/10.1111/1469-0691.12371

  • Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O, Meersseman W, Akova M, Arendrup MC, Arikan-Akdagli S, Bille J, Castagnola E, Cuenca-Estrella M, Donnelly JP, Groll AH, Herbrecht R, Hope WW, Jensen HE, Lass-Flörl C, Petrikkos G, Richardson MD, Roilides E, Verweij PE, Viscoli C, Ullmann AJ, ESCMID Fungal Infection Study Group (2012) ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect 18(Suppl 7):19–37. https://doi.org/10.1111/1469-0691.12039

    Article  CAS  PubMed  Google Scholar 

  • Cornely OA, Cuenca-Estrella M, Meis JF, Ullmann AJ (2014a) European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) and European Confederation of Medical Mycology (ECMM) 2013 joint guidelines on diagnosis and management of rare and emerging fungal diseases. Clin Microbiol Infect 20(Suppl 3):1–4. https://doi.org/10.1111/1469-0691.12569. PMID: 24606200

    Article  PubMed  Google Scholar 

  • Cornely OA, Arikan-Akdagli S, Dannaoui E, Groll AH, Lagrou K, Chakrabarti A, Lanternier F, Pagano L, Skiada A, Akova M, Arendrup MC, Boekhout T, Chowdhary A, Cuenca-Estrella M, Freiberger T, Guinea J, Guarro J, de Hoog S, Hope W, Johnson E, Kathuria S, Lackner M, Lass-Flörl C, Lortholary O, Meis JF, Meletiadis J, Muñoz P, Richardson M, Roilides E, Tortorano AM, Ullmann AJ, van Diepeningen A, Verweij P, Petrikkos G, European Society of Clinical Microbiology and Infectious Diseases Fungal Infection Study Group, European Confederation of Medical Mycology (2014b) ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013. Clin Microbiol Infect 20(Suppl 3):5–26. https://doi.org/10.1111/1469-0691.12371. PMID: 24479848

    Article  CAS  PubMed  Google Scholar 

  • Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-León DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild MJGT, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A, Mucormycosis ECMM MSG Global Guideline Writing Group (2019) Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis 19(12):e405–e421. https://doi.org/10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5. PMID: 31699664

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Desoubeaux G, Bailly É, Chandenier J (2014) Diagnosis of invasive pulmonary aspergillosis: updates and recommendations. Med Mal Infect 44(3):89–101. https://doi.org/10.1016/j.medmal.2013.11.006. Epub 2014 Feb 16. Review

    Article  CAS  PubMed  Google Scholar 

  • Du H, Bing J, Hu T, Ennis CL, Nobile CJ, Huang G (2020) Candida auris: Epidemiology, biology, antifungal resistance, and virulence. PLoS Pathog 16(10):e1008921. https://doi.org/10.1371/journal.ppat.1008921. PMID: 33091071; PMCID: PMC7581363

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Engelthaler DM, Hicks ND, Gillece JD, Roe CC, Schupp JM, Driebe EM, Gilgado F, Carriconde F, Trilles L, Firacative C, Ngamskulrungroj P, Castañeda E, Lazera Mdos S, Melhem MS, Pérez-Bercoff A, Huttley G, Sorrell TC, Voelz K, May RC, Fisher MC, Thompson GR 3rd, Lockhart SR, Keim P, Meyer W (2014) Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal. MBio 5(4):e01464–e01414. https://doi.org/10.1128/mBio.01464-14

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fishman JA, Gans H, AST Infectious Diseases Community of Practice (2019) Pneumocystis jiroveci in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl 33(9):e13587. https://doi.org/10.1111/ctr.13587. Epub 2019 Jul 1. PMID: 31077616

    Article  Google Scholar 

  • Freifeld AG, Bariola JR, Andes D (2010) The role of second-generation antifungal triazoles for treatment of the endemic mycoses. Curr Infect Dis Rep 12(6):471–478. https://doi.org/10.1007/s11908-010-0133-0

    Article  PubMed  Google Scholar 

  • Garnacho-Montero J, Olaechea P, Alvarez-Lerma F, Alvarez-Rocha L, Blanquer J, Galván B, Rodriguez A, Zaragoza R, Aguado JM, Mensa J, Solé A, Barberán J (2013) Epidemiology, diagnosis and treatment of fungal respiratory infections in the critically ill patient. Rev Esp Quimioter 26(2):173–188. Review

    PubMed  Google Scholar 

  • Ghembaza A, Vautier M, Cacoub P, Pourcher V, Saadoun D (2020) Risk factors and prevention of Pneumocystis jirovecii pneumonia in patients with autoimmune and inflammatory diseases. Chest 158(6):2323–2332. https://doi.org/10.1016/j.chest.2020.05.558. Epub 2020 Jun 2. PMID: 32502592

    Article  CAS  PubMed  Google Scholar 

  • Giacobbe DR, Maraolo AE, Simeon V, Magnè F, Pace MC, Gentile I, Chiodini P, Viscoli C, Sanguinetti M, Mikulska M, Fiore M, Bassetti M (2020) Changes in the relative prevalence of candidaemia due to non-albicans Candida species in adult in-patients: a systematic review, meta-analysis and meta-regression. Mycoses 63(4):334–342. https://doi.org/10.1111/myc.13054. PMID: 31997414

    Article  PubMed  Google Scholar 

  • Góralska K, Blaszkowska J, Dzikowiec M (2018) Neuroinfections caused by fungi. Infection 46(4):443–459. https://doi.org/10.1007/s15010-018-1152-2. Epub 2018 May 21. PMID: 29785613; PMCID: PMC6096918

    Article  PubMed Central  PubMed  Google Scholar 

  • Gould FK, Denning DW, Elliott TS, Foweraker J, Perry JD, Prendergast BD, Sandoe JA, Spry MJ, Watkin RW, Working Party of the British Society for Antimicrobial Chemotherapy (2012) Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother 67(2):269–289. https://doi.org/10.1093/jac/dkr450. Epub 2011 Nov 14. Review. Erratum in: J Antimicrob Chemother. 2012;67(5):1304

    Article  CAS  PubMed  Google Scholar 

  • He S, Hang JP, Zhang L, Wang F, Zhang DC, Gong FH (2014) A systematic review and meta-analysis of diagnostic accuracy of serum 1,3-β-d-glucan for invasive fungal infection: focus on cutoff levels. J Microbiol Immunol Infect pii:S 1684–1182(14)00120-0. https://doi.org/10.1016/j.jmii.2014.06.009. [Epub vor Druck] Review.

  • Hoenigl M, Prattes J, Spiess B, Wagner J, Prueller F, Raggam RB, Posch V, Duettmann W, Hoenigl K, Wölfler A, Koidl C, Buzina W, Reinwald M, Thornton CR, Krause R, Buchheidt D (2014) Performance of galactomannan, beta-d-glucan, Aspergillus lateral-flow device, conventional culture, and PCR tests with bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis. J Clin Microbiol 52(6):2039–2045. https://doi.org/10.1128/JCM.00467-14

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Jeffery-Smith A, Taori SK, Schelenz S, Jeffery K, Johnson EM, Borman A, Candida auris Incident Management Team, Manuel R, Brown CS (2017) Candida auris: a review of the literature. Clin Microbiol Rev 31(1):e00029-17. https://doi.org/10.1128/CMR.00029-17. PMID: 29142078; PMCID: PMC5740969

    Article  PubMed Central  PubMed  Google Scholar 

  • Kauffman CA, Fisher JF, Sobel JD, Newman CA (2011) Candida urinary tract infections-diagnosis. Clin Infect Dis 52(Suppl 6):S452–S456. https://doi.org/10.1093/cid/cir111. Review

  • Klimko N, Khostelidi S, Shadrivova O, Volkova A, Popova M, Uspenskaya O, Shneyder T, Bogomolova T, Ignatyeva S, Zubarovskaya L, Afanasyev B (2019) Contrasts between mucormycosis and aspergillosis in oncohematological patients. Med Mycol 57(Supplement_2):S138–S144. https://doi.org/10.1093/mmy/myy116. PMID: 30816977

    Article  CAS  PubMed  Google Scholar 

  • Koehler P, Cornely OA, Böttiger BW, Dusse F, Eichenauer DA, Fuchs F, Hallek M, Jung N, Klein F, Persigehl T, Rybniker J, Kochanek M, Böll B, Shimabukuro-Vornhagen A (2020) COVID-19 associated pulmonary aspergillosis. Mycoses 63(6):528–534. https://doi.org/10.1111/myc.13096. Epub 2020 May 15. PMID: 32339350; PMCID: PMC7267243

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Koehler P, Bassetti M, Chakrabarti A, Chen SCA, Colombo AL, Hoenigl M, Klimko N, Lass-Flörl C, Oladele RO, Vinh DC, Zhu LP, Böll B, Brüggemann R, Gangneux JP, Perfect JR, Patterson TF, Persigehl T, Meis JF, Ostrosky-Zeichner L, White PL, Verweij PE, Cornely OA, European Confederation of Medical Mycology, International Society for Human Animal Mycology, Asia Fungal Working Group, INFOCUS LATAM/ISHAM Working Group, ISHAM Pan Africa Mycology Working Group, European Society for Clinical Microbiology, Infectious Diseases Fungal Infection Study Group; ESCMID Study Group for Infections in Critically Ill Patients, Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy, Medical Mycology Society of Nigeria, Medical Mycology Society of China Medicine Education Association, Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology, Association of Medical Microbiology, Infectious Disease Canada (2021) Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance (2021 Jun). Lancet Infect Dis 21(6):e149–e162. https://doi.org/10.1016/S1473-3099(20)30847-1. Epub 2020 Dec 14. PMID: 33333012

  • Kontoyiannis DP, Marr KA, Park BJ, Alexander BD, Anaissie EJ, Walsh TJ, Ito J, Andes DR, Baddley JW, Brown JM, Brumble LM, Freifeld AG, Hadley S, Herwaldt LA, Kauffman CA, Knapp K, Lyon GM, Morrison VA, Papanicolaou G, Patterson TF, Perl TM, Schuster MG, Walker R, Wannemuehler KA, Wingard JR, Chiller TM, Pappas PG (2010) Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database (2010 Apr 15). Clin Infect Dis 50(8):1091–1100. https://doi.org/10.1086/651263

  • Kordalewska M, Perlin DS (2019) Identification of drug resistant Candida auris. Front Microbiol 10:1918. https://doi.org/10.3389/fmicb.2019.01918. PMID: 31481947; PMCID: PMC6710336

    Article  PubMed Central  PubMed  Google Scholar 

  • Kousha M, Tadi R, Soubani AO (2011) Pulmonary aspergillosis: a clinical review. Eur Respir Rev 20(121):156–174. https://doi.org/10.1183/09059180.00001011. Review

    Article  CAS  PubMed  Google Scholar 

  • Kullberg BJ, Viscoli C, Pappas PG, Vazquez J, Ostrosky-Zeichner L, Rotstein C, Sobel JD, Herbrecht R, Rahav G, Jaruratanasirikul S, Chetchotisakd P, Van Wijngaerden E, De Waele J, Lademacher C, Engelhardt M, Kovanda L, Croos-Dabrera R, Fredericks C, Thompson GR (2019) Isavuconazole versus caspofungin in the treatment of Candidemia and other invasive candida infections: the ACTIVE trial. Clin Infect Dis 68(12):1981–1989. https://doi.org/10.1093/cid/ciy827. PMID: 30289478

    Article  CAS  PubMed  Google Scholar 

  • Leroux S, Ullmann AJ (2013) Management and diagnostic guidelines for fungal diseases in infectious diseases and clinical microbiology: critical appraisal. Clin Microbiol Infect 19(12):1115–1121. https://doi.org/10.1111/1469-0691.12426. Review

    Article  CAS  PubMed  Google Scholar 

  • Limper AH, Adenis A, Le T, Harrison TS (2017) Fungal infections in HIV/AIDS. Lancet Infect Dis 17(11):e334–e343. https://doi.org/10.1016/S1473-3099(17)30303-1. Epub 2017 Jul 31. PMID: 28774701

    Article  PubMed  Google Scholar 

  • Lortholary O, Gangneux JP, Sitbon K, Lebeau B, de Monbrison F, Le Strat Y, Coignard B, Dromer F, Bretagne S, French Mycosis Study Group (2011) Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005–2007). Clin Microbiol Infect 17(12):1882–1889. https://doi.org/10.1111/j.1469-0691.2011.03548.x. Epub 2011 Jun 10

    Article  CAS  PubMed  Google Scholar 

  • Lortholary O, Petrikkos G, Akova M, Arendrup MC, Arikan-Akdagli S, Bassetti M, Bille J, Calandra T, Castagnola E, Cornely OA, Cuenca-Estrella M, Donnelly JP, Garbino J, Groll AH, Herbrecht R, Hope WW, Jensen HE, Kullberg BJ, Lass-Flörl C, Meersseman W, Richardson MD, Roilides E, Verweij PE, Viscoli C, Ullmann AJ, ESCMID Fungal Infection Study Group (2012) ESCMID* guideline for the diagnosis and management of Candida diseases 2012: patients with HIV infection or AIDS. Clin Microbiol Infect 18(Suppl 7):68–77. https://doi.org/10.1111/1469-0691.12042

    Article  CAS  PubMed  Google Scholar 

  • Maertens JA, Girmenia C, Brüggemann RJ, Duarte RF, Kibbler CC, Ljungman P, Racil Z, Ribaud P, Slavin MA, Cornely OA, Peter Donnelly J, Cordonnier C, European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and; European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and the European LeukemiaNet (ELN) (2018) European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia. J Antimicrob Chemother 73(12):3221–3230. https://doi.org/10.1093/jac/dky286. PMID: 30085172

    Article  CAS  PubMed  Google Scholar 

  • Martin-Loeches I, Antonelli M, Cuenca-Estrella M, Dimopoulos G, Einav S, De Waele JJ, Garnacho-Montero J, Kanj SS, Machado FR, Montravers P, Sakr Y, Sanguinetti M, Timsit JF, Bassetti M (2019) ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients. Intensive Care Med 45(6):789–805. https://doi.org/10.1007/s00134-019-05599-w. Epub 2019 Mar 25. PMID: 30911804

    Article  PubMed  Google Scholar 

  • Maschmeyer G, Carratalà J, Buchheidt D, Hamprecht A, Heussel CP, Kahl C, Lorenz J, Neumann S, Rieger C, Ruhnke M, Salwender H, Schmidt-Hieber M, Azoulay E (2015) Diagnosis and antimicrobial therapy of lung infiltrates in febrile neutropenic patients (allogeneic SCT excluded): updated guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)† (2015 Jan). Ann Oncol 26(1):21–33. https://doi.org/10.1093/annonc/mdu192. Epub 2014 May 15. PMID: 24833776

  • McKenney J, Smith RM, Chiller TM, Detels R, French A, Margolick J, Klausner JD, Centers for Disease Control and Prevention (2014) Prevalence and correlates of cryptococcal antigen positivity among AIDS patients–United States, 1986–2012. MMWR Morb Mortal Wkly Rep 63(27):585–587

    PubMed Central  PubMed  Google Scholar 

  • Mellinghoff SC, Panse J, Alakel N, Behre G, Buchheidt D, Christopeit M, Hasenkamp J, Kiehl M, Koldehoff M, Krause SW, Lehners N, von Lilienfeld-Toal M, Löhnert AY, Maschmeyer G, Teschner D, Ullmann AJ, Penack O, Ruhnke M, Mayer K, Ostermann H, Wolf HH, Cornely OA (2018) Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO). Ann Hematol 97(2):197–207. https://doi.org/10.1007/s00277-017-3196-2. Epub 2017 Dec 7. PMID: 29218389; PMCID: PMC5754425

    Article  PubMed  Google Scholar 

  • Mousset S, Buchheidt D, Heinz W, Ruhnke M, Cornely OA, Egerer G, Krüger W, Link H, Neumann S, Ostermann H, Panse J, Penack O, Rieger C, Schmidt-Hieber M, Silling G, Südhoff T, Ullmann AJ, Wolf HH, Maschmeyer G, Böhme A (2014) Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol 93(1):13–32. https://doi.org/10.1007/s00277-013-1867-1. Epub 2013 Sep 12. PubMed PMID: 24026426; PubMed Central PMCID: PMC3889633

    Article  CAS  PubMed  Google Scholar 

  • Nematollahi S, Dioverti-Prono V (2020) Cryptococcal infection in haematologic malignancies and haematopoietic stem cell transplantation. Mycoses 63(10):1033–1046. https://doi.org/10.1111/myc.13153. Epub 2020 Aug 23. PMID: 32740974

    Article  PubMed  Google Scholar 

  • Neumann S, Krause SW, Maschmeyer G, Schiel X, von Lilienfeld-Toal M, Infectious Diseases Working Party (AGIHO), German Society of Hematology and Oncology (DGHO) (2013) Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematological malignancies and solid tumors: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol 92(4):433–442. https://doi.org/10.1007/s00277-013-1698-0. Epub 2013 Feb 15. Review. PubMed PMID: 23412562; PubMed Central PMCID: PMC3590398

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD, Infectious Diseases Society of America (2009) Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 48(5):503–535. https://doi.org/10.1086/596757

    Article  CAS  PubMed  Google Scholar 

  • Pappas PG, Alexander BD, Andes DR, Hadley S, Kauffman CA, Freifeld A, Anaissie EJ, Brumble LM, Herwaldt L, Ito J, Kontoyiannis DP, Lyon GM, Marr KA, Morrison VA, Park BJ, Patterson TF, Perl TM, Oster RA, Schuster MG, Walker R, Walsh TJ, Wannemuehler KA, Chiller TM (2010) Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis 50(8):1101–1111. https://doi.org/10.1086/651262

    Article  PubMed  Google Scholar 

  • Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD (2016) Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis 62(4):e1–e50. https://doi.org/10.1093/cid/civ933. Epub 2015 Dec 16. PMID: 26679628; PMCID: PMC4725385

    Article  PubMed  Google Scholar 

  • Patterson JE, Peters J, Calhoon JH, Levine S, Anzueto A, Al-Abdely H, Sanchez R, Patterson TF, Rech M, Jorgensen JH, Rinaldi MG, Sako E, Johnson S, Speeg V, Halff GA, Trinkle JK (2000) Investigation and control of aspergillosis and other filamentous fungal infections in solid organ transplant recipients. Transpl Infect Dis 2(1):22–28

    Article  CAS  PubMed  Google Scholar 

  • Patterson TF (2010) Aspergillus species. In: Mandell GL, Bennett JE, Dolin R (Hrsg) Mandell, Douglas and Bennett’s principles and practice of infectious diseases. Churchill Livingstone, Philadelphia, S 3241–3256

    Chapter  Google Scholar 

  • Peppel RJ van de, van der Beek MT, Visser LG, de Boer MGJ, Wallinga J (2019) Managing invasive aspergillosis in haematological patients in the era of resistance polymerase chain reaction and increasing triazole resistance: a modelling study of different strategies. Int J Antimicrob Agents 53(3):284–293. https://doi.org/10.1016/j.ijantimicag.2018.10.021. Epub 2018 Nov 2. PMID: 30395989

  • Perfect JR (2010) Cryptococcus neoformans. In: Mandell GL, Bennett JE, Dolin R (Hrsg) Mandell, Douglas and Bennett’s principles and practice of infectious diseases. Churchill Livingstone, Philadelphia, S 3287–3304

    Chapter  Google Scholar 

  • Perfect JR (2013) Fungal diagnosis: how do we do it and can we do better? Curr Med Res Opin 29(Suppl 4):3–11. https://doi.org/10.1185/03007995.2012.761134. Review

    Article  CAS  PubMed  Google Scholar 

  • Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC (2010) Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin Infect Dis 50(3):291–322. https://doi.org/10.1086/649858

    Article  PubMed  Google Scholar 

  • Risum M, Helweg-Larsen J, Petersen SL, Kampmann P, Overgaard UM, El Fassi D, Nielsen OJ, Brabrand M, Rubek N, Munksgaard L, Severinsen MT, Nielsen B, Gertsen JB, Gylfe Å, Hjort U, Vourtsi A, Hare RK, Arendrup MC (2020) Introduction of a comprehensive diagnostic and interdisciplinary management approach in haematological patients with mucormycosis: a pre and post-intervention analysis. J Fungi (Basel) 6(4):268. https://doi.org/10.3390/jof6040268. PMID: 33171634; PMCID: PMC7712937

    Article  CAS  Google Scholar 

  • Ruhnke M, Böhme A, Buchheidt D, Cornely O, Donhuijsen K, Einsele H, Enzensberger R, Hebart H, Heussel CP, Horger M, Hof H, Karthaus M, Krüger W, Maschmeyer G, Penack O, Ritter J, Schwartz S, Infectious Diseases Working Party in Haematology and Oncology of the German Society for Haematology and Oncology (2012) Diagnosis of invasive fungal infections in hematology and oncology–guidelines from the Infectious Diseases Working Party in Haematology and Oncology of the German Society for Haematology and Oncology (AGIHO). Ann Oncol 23(4):823–833. https://doi.org/10.1093/annonc/mdr407. Epub 2011 Sep 23. Review

    Article  CAS  PubMed  Google Scholar 

  • Saag MS, Graybill RJ, Larsen RA, Pappas PG, Perfect JR, Powderly WG, Sobel JD, Dismukes WE (2000) Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. Clin Infect Dis 30(4):710–718. Epub 2000 Apr 20

    Article  CAS  PubMed  Google Scholar 

  • Sanchini A, Smith IM, Sedlacek L, Schwarz R, Tintelnot K, Rickerts V (2014) Molecular typing of clinical cryptococcus neoformans isolates collected in Germany from 2004 to 2010. Med Microbiol Immunol. 203(5):333–340. https://doi.org/10.1007/s00430-014-0341-6. Epub 2014 May 17. PMID: 24838744

  • Sloan DJ, Parris V (2014) Cryptococcal meningitis: epidemiology and therapeutic options. Clin Epidemiol 6:169–182. https://doi.org/10.2147/CLEP.S38850. eCollection 2014. Review. PubMed PMID: 24872723; PubMed Central PMCID: PMC4026566

    Article  PubMed Central  PubMed  Google Scholar 

  • Tacke D, Koehler P, Cornely OA (2013) Fungal endocarditis. Curr Opin Infect Dis 26(6):501–507. https://doi.org/10.1097/QCO.0000000000000009. Review

    Article  CAS  PubMed  Google Scholar 

  • Tasaka S, Tokuda H (2012) Pneumocystis jirovecii pneumonia in non-HIV-infected patients in the era of novel immunosuppressive therapies. J Infect Chemother 18(6):793–806. https://doi.org/10.1007/s10156-012-0453-0. Epub 2012 Aug 6. Review

    Article  CAS  PubMed  Google Scholar 

  • Thery A, Espitalier F, Cassagnau E, Durand N, Malard O (2012) Clinical features and outcome of sphenoid sinus aspergillosis: a retrospective series of 15 cases. Eur Ann Otorhinolaryngol Head Neck Dis 129(4):179–184. https://doi.org/10.1016/j.anorl.2011.06.005. Epub 2012 Mar 22. Review

    Article  CAS  PubMed  Google Scholar 

  • Tissot F, Agrawal S, Pagano L, Petrikkos G, Groll AH, Skiada A, Lass-Flörl C, Calandra T, Viscoli C, Herbrecht R (2017) ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients. Haematologica 102(3):433–444. https://doi.org/10.3324/haematol.2016.152900. Epub 2016 Dec 23. PMID: 28011902; PMCID: PMC5394968

    Article  PubMed Central  PubMed  Google Scholar 

  • Tunnicliffe G, Schomberg L, Walsh S, Tinwell B, Harrison T, Chua F (2013) Airway and parenchymal manifestations of pulmonary aspergillosis. Respir Med 107(8):1113–1123. https://doi.org/10.1016/j.rmed.2013.03.016. Epub 2013 May 20. Review

    Article  PubMed  Google Scholar 

  • Ullmann AJ, Akova M, Herbrecht R, Viscoli C, Arendrup MC, Arikan-Akdagli S, Bassetti M, Bille J, Calandra T, Castagnola E, Cornely OA, Donnelly JP, Garbino J, Groll AH, Hope WW, Jensen HE, Kullberg BJ, Lass-Flörl C, Lortholary O, Meersseman W, Petrikkos G, Richardson MD, Roilides E, Verweij PE, Cuenca-Estrella M, ESCMID Fungal Infection Study Group (2012) ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT). Clin Microbiol Infect 18(Suppl 7):53–67. https://doi.org/10.1111/1469-0691.12041

    Article  CAS  PubMed  Google Scholar 

  • Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA (2018) Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect 24(Suppl 1):e1–e38. https://doi.org/10.1016/j.cmi.2018.01.002. Epub 2018 Mar 12. PMID: 29544767

    Article  PubMed  Google Scholar 

  • Vargas SL, Hughes WT, Santolaya ME, Ulloa AV, Ponce CA, Cabrera CE, Cumsille F, Gigliotti F (2001) Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants. Clin Infect Dis 32(6):855–861. Epub 2001 Mar 9

    Article  CAS  PubMed  Google Scholar 

  • Vehreschild JJ, Birtel A, Vehreschild MJ, Liss B, Farowski F, Kochanek M, Sieniawski M, Steinbach A, Wahlers K, Fätkenheuer G, Cornely OA (2013) Mucormycosis treated with posaconazole: review of 96 case reports. Crit Rev Microbiol 39(3):310–324. https://doi.org/10.3109/1040841X.2012.711741. Epub 2012 Aug 24. Review

    Article  CAS  PubMed  Google Scholar 

  • Verweij PE, Rijnders BJA, Brüggemann RJM, Azoulay E, Bassetti M, Blot S, Calandra T, Clancy CJ, Cornely OA, Chiller T, Depuydt P, Giacobbe DR, Janssen NAF, Kullberg BJ, Lagrou K, Lass-Flörl C, Lewis RE, Liu PW, Lortholary O, Maertens J, Martin-Loeches I, Nguyen MH, Patterson TF, Rogers TR, Schouten JA, Spriet I, Vanderbeke L, Wauters J, van de Veerdonk FL (2020) Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion. Intensive Care Med 46(8):1524–1535. https://doi.org/10.1007/s00134-020-06091-6. Epub 2020 Jun 22. PMID: 32572532; PMCID: PMC7306567

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wakefield AE, Lindley AR, Ambrose HE, Denis CM, Miller RF (2003) Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients. J Infect Dis 187(6):901–908. https://doi.org/10.1086/368165. Epub 2003 Mar 6. PMID: 12660936

    Article  PubMed  Google Scholar 

  • Walzer PD (1999) Immunological features of Pneumocystis carinii infection in humans. Clin Diagn Lab Immunol 6(2):149–155. Review. PubMed PMID: 10066645; PubMed Central PMCID: PMC95678

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walzer PD (2010) Pneumocystis species. In: Mandell GL, Bennett JE, Dolin R (Hrsg) Mandell, Douglas and Bennett’s principles and practice of infectious diseases. Churchill Livingstone, Philadelphia, S 3377–3390

    Chapter  Google Scholar 

  • WHO (2011) Rapid advice: diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children. December 2011. http://www.who.int/iris/handle/10665/44786. Zugegriffen am 01.09.2014

  • WHO (2018) Guidelines for The Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children: Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. World Health Organization, Geneva. PMID: 30285342

    Google Scholar 

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Cornely, O., Wisplinghoff, H. (2021). Organmykosen. In: Lehnert, H., Märker-Hermann, E., Marx, N., Meyhöfer, S.M. (eds) DGIM Innere Medizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54676-1_539-2

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    Organmykosen
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    DOI: https://doi.org/10.1007/978-3-642-54676-1_539-3

  2. Organmykosen
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    DOI: https://doi.org/10.1007/978-3-642-54676-1_539-2

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    Organmykosen
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    DOI: https://doi.org/10.1007/978-3-642-54676-1_539-1