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Nichtobstruktive Azoospermie

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Die Urologie

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Zusammenfassung

Der Begriff der nichtobstruktiven Azoospermie (NOA) kennzeichnet die Befundkonstellation infertiler Männer, bei denen primär eine Produktionsstörung der Spermien im Hoden besteht. Liegt eine hypothalamisch-hypophysär bedingte Erkrankung im Sinne eines hypogonadotropen Hypogonadismus vor, ist eine kausale medikamentöse Therapie möglich. Für die meisten primär den Hoden betreffenden Schäden gilt dies nicht, insbesondere bei kongenitale Störungen wie Maldescensus testis, Klinefelter-Syndrom und Mikrodeletionen des Y-Chromosoms. Für die betroffenen Patienten kommen lediglich operative Verfahren zur Spermiengewinnung (testikuläre Spermienextraktion, TESE) in Betracht. In 40–60 % der Fälle lassen sich fokal Samenkanälchen mit erhaltener Spermatogeneseaktivität und damit elongierte Spermatiden für eine assistierte Fertilisation finden.

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Authors and Affiliations

  1. Sektion Konservative Andrologie, Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen und Marburg GmbH, Giessen, Deutschland

    Hans-Christian Schuppe

  2. Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen und Marburg GmbH, Gießen, Deutschland

    Adrian Pilatz & Thorsten Diemer

  3. Institut für Veterinäranatomie, -Histologie und -Embryologie, Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen und Marburg GmbH, Gießen, Deutschland

    Daniela Fietz

  4. Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Dekanat Fachbereich Medizin, Justus-Liebig-Universität Gießen, Gießen, Deutschland

    Wolfgang Weidner

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  1. Hans-Christian Schuppe
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  2. Adrian Pilatz
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  3. Daniela Fietz
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  4. Wolfgang Weidner
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  5. Thorsten Diemer
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Correspondence to Hans-Christian Schuppe .

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Editors and Affiliations

  1. Klinik für Urologie, Universitätsmedizin Mannheim, Mannheim, Baden-Württemberg, Deutschland

    Maurice Stephan Michel

  2. Klinik für Urologie, Universitätsklinikum Mainz, Mainz, Deutschland

    Joachim W. Thüroff

  3. Abt. für Urologie, Universitätsklinikum Salzburg, Salzburg, Salzburg, Österreich

    Günther Janetschek

  4. Klinik und Poliklinik für Urologie, Univer Tech Univ Dresden, Dresden, Sachsen, Deutschland

    Manfred P. Wirth

Section Editor information

  1. Klinik für Urologie, Kliniken Maria Hilf GmbH, Mönchengladbach, Deutschland

    Herbert Sperling

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Schuppe, HC., Pilatz, A., Fietz, D., Weidner, W., Diemer, T. (2022). Nichtobstruktive Azoospermie. In: Michel, M.S., Thüroff, J.W., Janetschek, G., Wirth, M.P. (eds) Die Urologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41168-7_162-2

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  • DOI: https://doi.org/10.1007/978-3-642-41168-7_162-2

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  1. Latest

    Nichtobstruktive Azoospermie
    Published:
    14 October 2022

    DOI: https://doi.org/10.1007/978-3-642-41168-7_162-2

  2. Original

    Nichtobstruktive Azoospermie
    Published:
    12 June 2015

    DOI: https://doi.org/10.1007/978-3-642-41168-7_162-1

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