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Oxidative Stress and Ion Channels

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Systems Biology of Free Radicals and Antioxidants

Abstract

The gating properties of ion channels can be significantly altered by the intracellular redox status. Reactive oxygen (ROS) and nitrogen (RNS) species induce posttranslational modifications targeted at specific residues within the pore-forming subunits. These include redox modification of sulfhydryl groups of cysteine residues by ROS, s-nitrosylation by nitric oxide, and/or nitration of tyrosine residues by peroxynitrite. The functional activity of a number of ion channels has been examined directly in response to oxidizing agents or following oxidative stress. This chapter summarizes some of the known changes in channel regulation by ROS/RNS both from a biophysical standpoint and in disease states.

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Acknowledgments

This work was supported by the National Institutes of Health (NIH) DK046367 and NIHDA024009.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, 1112 E. Clay Street, McGuire Hall 317, Richmond, VA, 23298, USA

    Hamid I. Akbarali

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Correspondence to Hamid I. Akbarali .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Akbarali, H.I. (2014). Oxidative Stress and Ion Channels. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_12

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