Skip to main content

HIV and Osteoporosis

  • Chapter
  • First Online:
Male Osteoporosis

Part of the book series: Trends in Andrology and Sexual Medicine ((TASM))

  • 349 Accesses

Abstract

The advent of highly active antiretroviral therapy (HAART) has significantly improved the survival of people living with human immunodeficiency virus (HIV) infection [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Powderly WG (2012) Osteoporosis and bone health in HIV. Curr HIV/AIDS Rep 9(3):218–222

    Article  Google Scholar 

  2. Neuhaus J, Angus B, Kowalska JD et al (2010) Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV. AIDS 24(5):697–706

    Article  Google Scholar 

  3. Fausto A, Bongiovanni M, Cicconi P et al (2006) Potential predictive factors of osteoporosis in HIV-positive subjects. Bone 38(6):893–897

    Article  Google Scholar 

  4. Knobel H, Guelar A, Vallecillo G, Nogues X, Diez A (2001) Osteopenia in HIV-infected patients: is it the disease or is it the treatment? AIDS 15(6):807–808

    Article  CAS  Google Scholar 

  5. Moore AL, Vashisht A, Sabin CA et al (2001) Reduced bone mineral density in HIV-positive individuals. AIDS 15(13):1731–1733

    Article  CAS  Google Scholar 

  6. Tebas P, Powderly WG, Claxton S et al (2000) Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. AIDS 14(4):F63–F67

    Article  CAS  Google Scholar 

  7. Borderi M, Gibellini D, Vescini F et al (2009) Metabolic bone disease in HIV infection. AIDS 23(11):1297–1310

    Article  Google Scholar 

  8. Ilha T, Comim FV, Copes RM, Compston JE, Premaor MO (2018) HIV and vertebral fractures: a systematic review and meta-analysis. Sci Rep 8(1):7838

    Article  Google Scholar 

  9. Brown TT, Hoy J, Borderi M et al (2015) Recommendations for evaluation and management of bone disease in HIV. Clin Infect Dis 60(8):1242–1251

    Article  Google Scholar 

  10. Gonciulea A, Wang R, Althoff KN et al (2017) An increased rate of fracture occurs a decade earlier in HIV+ compared with HIV− men. AIDS 31(10):1435–1443

    Article  Google Scholar 

  11. Nasi M, De Biasi S, Gibellini L et al (2017) Ageing and inflammation in patients with HIV infection. Clin Exp Immunol 187(1):44–52

    Article  CAS  Google Scholar 

  12. Vescini F, Cozzi-Lepri A, Borderi M et al (2011) Prevalence of hypovitaminosis D and factors associated with vitamin D deficiency and morbidity among HIV-infected patients enrolled in a large Italian cohort. J Acquir Immune Defic Syndr 58(2):163–172

    Article  CAS  Google Scholar 

  13. Rochira V, Guaraldi G (2014) Hypogonadism in the HIV-infected man. Endocrinol Metab Clin North Am 43(3):709–730

    Article  Google Scholar 

  14. Wong N, Levy M, Stephenson I (2017) Hypogonadism in the HIV-infected man. Curr Treat Options Infect Dis 9(1):104–116

    Article  Google Scholar 

  15. Golds G, Houdek D, Arnason T (2017) Male hypogonadism and osteoporosis: the effects, clinical consequences, and treatment of testosterone deficiency in bone health. Int J Endocrinol 2017:4602129

    Article  Google Scholar 

  16. Santi D, Madeo B, Carli F et al (2016) Serum total estradiol, but not testosterone is associated with reduced bone mineral density (BMD) in HIV-infected men: a cross-sectional, observational study. Osteoporos Int 27(3):1103–1114

    Article  CAS  Google Scholar 

  17. Pepe J, Isidori AM, Falciano M et al (2014) Effect of risedronate in osteoporotic HIV males, according to gonadal status: a pilot study. Endocrine 47(2):456–462

    Article  CAS  Google Scholar 

  18. Bolland MJ, Grey AB, Horne AM et al (2006) Bone mineral density is not reduced in HIV-infected Caucasian men treated with highly active antiretroviral therapy. Clin Endocrinol (Oxf) 65(2):191–197

    Article  Google Scholar 

  19. Jacobson DL, Spiegelman D, Knox TK, Wilson IB (2008) Evolution and predictors of change in total bone mineral density over time in HIV-infected men and women in the nutrition for healthy living study. J Acquir Immune Defic Syndr 49(3):298–308

    Article  CAS  Google Scholar 

  20. Brown TT, Qaqish RB (2006) Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review. AIDS 20(17):2165–2174

    Article  Google Scholar 

  21. Sax PE, Wohl D, Yin MT et al (2015) Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials. Lancet 385(9987):2606–2615

    Article  CAS  Google Scholar 

  22. Penning-van Beest FJ, Erkens JA, Olson M, Herings RM (2008) Loss of treatment benefit due to low compliance with bisphosphonate therapy. Osteoporos Int 19(4):511–517

    Article  CAS  Google Scholar 

  23. Negredo E, Bonjoch A, Perez-Alvarez N et al (2015) Comparison of two different strategies of treatment with zoledronate in HIV-infected patients with low bone mineral density: single dose versus two doses in 2 years. HIV Med 16(7):441–448

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fabio Vescini .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Vescini, F., Porcelli, T., Grimaldi, F. (2020). HIV and Osteoporosis. In: Ferlin, A., Migliaccio, S. (eds) Male Osteoporosis. Trends in Andrology and Sexual Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-96376-1_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-96376-1_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-96375-4

  • Online ISBN: 978-3-319-96376-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics