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Heat Shock Protein Expression in Various Tissues in Thermal Stress

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Regulation of Heat Shock Protein Responses

Part of the book series: Heat Shock Proteins ((HESP,volume 13))

Abstract

Heat shock proteins (Hsp) have a cytoprotective function and support the cell to survive in (sub) lethal conditions. Expression of Hsp is stimulated by several stress conditions, including hypo- and hyperthermia. Immunohistochemical expression of Hsp is studied in forensic medicine, mainly in victims of hypothermia, fire, sudden infant death syndrome (SIDS), and amphetamine-related deaths. Hsp expression has been observed in cardiac tissue in fire victims, in hypothermia, and in amphetamine-related deaths, but at a lower degree compared with in the kidney or pulmonary tissue. Hsp27 expression is present in cases of fatal hypothermia in the pituitary gland. In SIDS victims, there is no Hsp expression in cardiac tissue, but low expression is found in pulmonary and renal tissues. In fire-related fatalities, an extensive and different expression pattern of Hsp27 and Hsp70 according to the survival time can be observed. Hsp27 is rapidly expressed in short-term survivors and Hsp70 is higher in long-term survivors. In the future, Hsp expression in cardiac tissue in myocardial infarction and coronary insufficiency should be studied.

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  1. Institute of Legal Medicine, Rheinische Friedrich-Wilhlems University Bonn, Bonn, Germany

    Elke Doberentz & Burkhard Madea

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  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A A Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Doberentz, E., Madea, B. (2018). Heat Shock Protein Expression in Various Tissues in Thermal Stress. In: Asea, A., Kaur, P. (eds) Regulation of Heat Shock Protein Responses. Heat Shock Proteins, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-319-74715-6_18

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