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Diabetes Mellitus and Exercise Physiology in the Presence of Diabetic Comorbidities

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Diabetes and Exercise

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

While uncomplicated type 2 diabetes mellitus (T2DM) is already associated with an impaired exercise capacity, the presence of other comorbidities appears to further worsen exercise capacity in T2DM. Common diabetic comorbidities such as hypertension, arterial stiffness, cardiovascular disease, systolic dysfunction, diastolic dysfunction, pulmonary disease, and diabetic nephropathy are all associated with worse exercise capacity in T2DM. Benefits of exercise training programs for those with T2DM and certain comorbidities (e.g., hypertension, increased arterial stiffness, or post-myocardial infarction) have been shown to include improved exercise capacity. Exercise has also been shown to improve other complications and comorbidities of diabetes including neuropathy, fatty liver, obstructive sleep apnea, and nephropathy, but the independent effect of these benefits on exercise capacity has not been defined. Further study is warranted to determine the specific benefits and risks of exercise training in subpopulations of T2DM such as those with T2DM and either congestive heart failure or microvascular complications of diabetes.

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Authors and Affiliations

  1. Anschutz Medical Campus, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado, Mailstop 8106, Aurora, CO, USA

    Irene E. Schauer MD, PhD

  2. Department of Medicine, Endocrinology Section, MS111H, Denver VA Medical Center, Denver, CO, 80220, USA

    Irene E. Schauer MD, PhD

  3. Department of Medicine, Division of General Internal Medicine and Center for Women’s Health Research, University of Colorado School of Medicine, 12631 E. 17th Ave, Mailstop B-180, Aurora, CO, 80045, USA

    Amy G. Huebschmann MD, MS & Judith G. Regensteiner PhD, MA, BA

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  1. Irene E. Schauer MD, PhD
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  2. Amy G. Huebschmann MD, MS
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  3. Judith G. Regensteiner PhD, MA, BA
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Correspondence to Irene E. Schauer MD, PhD .

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Editors and Affiliations

  1. Department of Medicine, Division of Endocrinology Metabolism and Diabetes and Center for Women’s Health Research, University of Colorado, Aurora, Colorado, USA

    Jane E. B. Reusch, MD

  2. Department of Medicine, Division of General Internal Medicine and Center for Women’s Health Research, University of Colorado School of Medicine, Aurora, Colorado, USA

    Judith G. Regensteiner, PhD, MA, BA

  3. Clinical and Research Exercise Physiology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Kerry J. Stewart, Ed.D., FAHA, MAACVPR, FACSM

  4. Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

    Aristidis Veves, MD, DSc

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Schauer, I.E., Huebschmann, A.G., Regensteiner, J.G. (2018). Diabetes Mellitus and Exercise Physiology in the Presence of Diabetic Comorbidities. In: Reusch, MD, J., Regensteiner, PhD, MA, BA, J., Stewart, Ed.D., FAHA, MAACVPR, FACSM , K., Veves, MD, DSc, A. (eds) Diabetes and Exercise. Contemporary Diabetes. Humana Press, Cham. https://doi.org/10.1007/978-3-319-61013-9_18

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