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Bone Morphogenetic Proteins in the Initiation and Progression of Breast Cancer

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Bone Morphogenetic Proteins: Systems Biology Regulators

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Due to their vast roles in human development, differentiation, homeostasis, and disease, bone morphogenetic proteins (BMP) have evolved along with numerous potentiating and inhibitory mechanisms to fine-tune signaling outcomes. As such, this chapter focuses on some of the best-studied and utilized extracellular mechanisms of BMP signal regulation. Due to their inherent binding characteristics, BMP ligands are often found engaged with at least of one of these many interacting partners. From a structural and functional perspective, we discuss our current understanding of how BMP ligands interact with these numerous binding partners, including secreted extracellular antagonists, BMP prodomains, and various co-receptors and noncanonical binding partners. Interestingly, while the BMP ligands themselves exhibit very redundant structural features, the composition and structure of their interacting proteins is quite diverse, lending to different ligand-binding modes and mechanisms, which lead to very different biological outcomes. Collectively, biochemical and structural characterization of these important interactions has provided valuable insight into BMP signal regulation.

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Acknowledgments

We are grateful to Philip Owens, Miriam de Boeck, and Hans van Dam for critical reading and comments. Our studies on BMP in cancer and vascular diseases are supported by the Cancer Genomics Centre, Netherlands, and Swedish Cancerfonden (090773).

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Authors and Affiliations

  1. Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden University Medical Center, Leiden, The Netherlands

    Jiang Ren & Peter ten Dijke

  2. Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 75124, Uppsala, Sweden

    Peter ten Dijke

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  1. Jiang Ren
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Correspondence to Peter ten Dijke .

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  1. School of Medicine, University of Zagreb, Zagreb, Croatia

    Slobodan Vukicevic

  2. perForm Biologics Inc, Holliston, Massachusetts, USA

    Kuber T. Sampath

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Ren, J., ten Dijke, P. (2017). Bone Morphogenetic Proteins in the Initiation and Progression of Breast Cancer. In: Vukicevic, S., Sampath, K. (eds) Bone Morphogenetic Proteins: Systems Biology Regulators. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-47507-3_18

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