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Variant Adenocarcinomas of the Gallbladder

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

The most common adenocarcinoma of the gallbladder is derived from the glandular epithelium. In addition, there are several variants of adenocarcinoma that are distinguished from the standard form by variant differentiation patterns. One form of gallbladder adenocarcinoma is characterized by abundant production and secretion of mucin, resulting in extracellular mucin lakes. This is mucinous carcinoma, a rare tumor of which only relatively few reports are published, mainly occurring in older patients. In contrast to ordinary gallbladder carcinoma, female preponderance is not present. A second variant of adenocarcinoma with mucin production is associated with deficient mucin secretion, resulting in signet-ring cells. Signet-ring cell carcinoma is a very rare gallbladder cancer with a highly aggressive course. There are several other, very rare variants of gallbladder adenocarcinoma. They include cribriform carcinoma, micropapillary carcinoma, cervix carcinoma-like carcinoma, carcinoma with morule-like features, clear cell carcinoma, carcinoma with lymphoid stroma, and undifferentiated carcinomas.

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    Arthur Zimmermann

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Zimmermann, A. (2017). Variant Adenocarcinomas of the Gallbladder. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_150

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