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The MRL Mouse: A Model of Regeneration and Cancer

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Murine Models, Energy Balance, and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 10))

Abstract

The intersection of regeneration and cancer has long been hypothesized to be due to the well-established inverse relationship between the capacity to heal and the propensity for cancer.

The MRL mouse, a mammalian model of regeneration, provides an opportunity to experimentally explore this hypothesis. We present data relating to metabolism, inflammation, genetics, and diet, which not only support the hypothesis but also provide mechanistic insight linking these pro-carcinogenic traits.

In particular, this mouse has many elements of the tumor microenvironment such as a pro-inflammatory response, enhanced regenerative healing under a high-fat diet (HFD), an environment supportive of tumor growth, the use of a basal metabolism with aerobic glycolysis reminiscent of the Warburg effect, and although it is permissive for tumor transplantation, it is resistant to cancer induction. Genetic studies on the role of pro-inflammatory HFDs and regenerative capacity provide links to dissecting these relationships.

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Acknowledgements

Funding Declaration

The authors declare no competing interests in the studies discussed in this chapter. Funds for this research were supported by the national institutes of health (NIDCR and NIGMS) and the department of defense (DARPA). This research was also supported by a grant from the PA Department of Health Commonwealth Universal Research Enhancement (CURE) Program and from the PA Breast Cancer Coalition. Support for shared resources utilized in these studies was provided by the Cancer Center Support Grant (CCSG) CA010815 to The Wistar Institute EHK is supported by a grant from NCI.

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  1. The Wistar Institute, 3601 Spruce Street, 19104, Philadelphia, PA, USA

    Ellen Heber-Katz PhD

  2. UCSD School of Medicine, 214 Dickinson St., Room C-102, 92103-8467, San Diego, CA, USA

    Robert K. Naviaux MD, PhD

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  1. Ellen Heber-Katz PhD
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  2. Robert K. Naviaux MD, PhD
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Correspondence to Ellen Heber-Katz PhD .

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  1. Center for Science, Health & Society, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Nathan A. Berger

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Heber-Katz, E., Naviaux, R. (2015). The MRL Mouse: A Model of Regeneration and Cancer. In: Berger, N. (eds) Murine Models, Energy Balance, and Cancer. Energy Balance and Cancer, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-319-16733-6_3

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