Abstract
AICP is a crucial process that maintaining tissue homeostasis and regeneration. In the past, cell death was perceived merely as a means to discard cells without functional consequences. However, during regeneration, effector caspases orchestrate apoptosis, releasing signals that activate stem cells, thereby compensating for tissue loss across various animal models. Despite significant progress, the activation of Wnt3a by caspase-3 remains a focal point of research gaps in AICP mechanisms, spanning from lower to higher regenerative animals. This inquiry into the molecular intricacies of caspase-3-induced Wnt3a activation contributes to a deeper understanding of the links between regeneration and cancer mechanisms. Our report provides current updates on AICP pathways, delineating research gaps and highlighting the potential for future investigations aimed at enhancing our comprehension of this intricate process.
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Acknowledgements
Authors thank ‘International Research Centre (IRC) of Sathyabama Institute of Science and Technology, Chennai’ for providing support to carry out the research work. Also, we express our gratitude to Dr. Ramakrishnan Muthusamy, Bamboo Research Institute, Nanjing Forestry University, Nanjing, China for helping us to create the figures using biorender (www.biorender.com).
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This work was supported by the DST-SHRI-INDIA (Ref. No. DST/TDT/SHRI- 24/2021 (G)).
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J.D.S.C: conceptualization, investigation, editing and wrote the manuscript. K.R: conceptualization, editing and wrote the manuscript. K.S.C: critical reviewing and visualization. K.K: conceptualization, editing, critical reviewing and wrote the manuscript. P.D: visualization.M.D: formal analysis. N.B: formal analysis. K.M: formal analysis.
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Rajagopalan, K., Selvan Christyraj, J., Chelladurai, K.S. et al. Understanding the molecular mechanism of regeneration through apoptosis-induced compensatory proliferation studies - updates and future aspects. Apoptosis (2024). https://doi.org/10.1007/s10495-024-01958-1
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DOI: https://doi.org/10.1007/s10495-024-01958-1