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Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions

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Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials

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Abstract

This chapter summarizes the clinical evidence supporting antimalarial combination therapy and provides details of studies that describe in vivo and in vitro drug interactions in which co-administered antimalarial or non-antimalarial drugs affect the pharmacokinetics of various antimalarials and vice versa.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada

    Tony K. L. Kiang & Mary H. H. Ensom

  2. College of Pharmacy, Qatar University, Doha, Qatar

    Kyle John Wilby

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  1. Tony K. L. Kiang
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  2. Kyle John Wilby
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  3. Mary H. H. Ensom
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Kiang, T.K.L., Wilby, K.J., Ensom, M.H.H. (2015). Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions. In: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials. Adis, Cham. https://doi.org/10.1007/978-3-319-10527-7_7

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  • DOI: https://doi.org/10.1007/978-3-319-10527-7_7

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  • Publisher Name: Adis, Cham

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