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Rodent Modeling of Aggression: Elucidating the Role of Cytokines in the Brain

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  • First Online:
Handbook of Anger, Aggression, and Violence

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Abstract

Aggression is an intrinsic behavior of most species. Escalated aggression is a common symptom of neuropsychiatric disorders (schizophrenia, substance abuse, autism spectrum disorders, depression), which are known to be associated with immune dysfunction. Increasing evidence from clinical and animal studies suggests a role of inflammation and immunologic processes in modulating behavior. This review focuses on the data obtained on the basis of multiple rodent models of aggression indicating a link between immunity, cytokines, and aggression. The current literature revealed that aggression induced by chronic exposure to psychological stress or genetic factors has a profound impact on peripheral immune responses and cytokine production accompanied by changes in cytokine profiles within brain regions involved in behavioral control and immunomodulation. These findings indicate that cytokine dysregulation might contribute to neuroimmune mechanisms underlying aggressive behavior that can assist in developing new approaches to the treatments of affective disorders.

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Abbreviations

5-HT:

serotonin

ACTH:

adrenocorticotropic hormone

BDNF:

brain-derived neurotrophic factor

CRP:

C-reactive protein

DA:

dopamine

DISC1:

disrupted-in-schizophrenia-1

DRN:

dorsal raphe nucleus

GABA:

γ-aminobutyric acid

HPA axis:

hypothalamus-pituitary-adrenal axis

IFN:

interferon

IL:

interleukin

LPS:

lipopolysaccharide

MCP:

monocyte chemoattractant protein

NF-κB:

transcription factor

PAG:

periaqueductal gray

TLR:

toll-like receptor

TNF:

tumor necrosis factor

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Authors and Affiliations

  1. FSBSI “Scientific Research Institute of Neurosciences and Medicine”, Novosibirsk, Russia

    Elizaveta Alperina, Galina Idova & Svetlana Zhanaeva

Authors
  1. Elizaveta Alperina
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  2. Galina Idova
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  3. Svetlana Zhanaeva
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Correspondence to Elizaveta Alperina .

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Editors and Affiliations

  1. Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

    Colin R. Martin

  2. Faculty of Life Sciences and Medicine, King’s College London, London, UK

    Victor R. Preedy

  3. School of Life Sciences, University of Westminster, London, UK

    Vinood B. Patel

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Alperina, E., Idova, G., Zhanaeva, S. (2023). Rodent Modeling of Aggression: Elucidating the Role of Cytokines in the Brain. In: Martin, C.R., Preedy, V.R., Patel, V.B. (eds) Handbook of Anger, Aggression, and Violence. Springer, Cham. https://doi.org/10.1007/978-3-031-31547-3_150

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