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Innovations in Intensive Care Nephrology

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Innovations in Nephrology

Abstract

Acute kidney injury (AKI) is a sudden loss of kidney function that results in the accumulation of urea and other nitrogenous waste products as well as abnormal control of extracellular fluid volume and electrolytes. With rising incidence worldwide among critically ill patients, AKI is associated with an increased risk of both short-term and long-term mortality. During the past decade, many advances in the field of critical care nephrology have occurred including innovations in setting standard criteria for diagnosis and staging of AKI (Kidney Disease Improving Global Outcomes, KDIGO 2012 criteria). These criteria do not only unify the diagnostic criteria but also emphasizes the important of early AKI detection. With the delay in rising of serum creatinine after kidney injury, the discovery of novel AKI biomarkers such as neutrophil gelatinase-associated lipocalin, or tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 has filled the gap of early AKI detection. Most AKI patients requiring renal support die due to multiple-organ failure, not renal dysfunction. Novel technologies in renal replacement therapy and blood purification will support hemodynamic instability and may improve outcome. Survivors from severe AKI have the consequences including incident chronic kidney disease (CKD), CKD progression, end stage renal disease. The multidisciplinary care team may improve those complication. Finally, these innovations in critical care nephrology have worked to greatly improve AKI outcomes.

Prit Kusirisin and Piyanut Kaewdoungtien are co-first author.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Prit Kusirisin, Piyanut Kaewdoungtien, Sadudee Peerapornratana & Nattachai Srisawat

  2. Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand

    Prit Kusirisin, Piyanut Kaewdoungtien, Sadudee Peerapornratana & Nattachai Srisawat

  3. Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Prit Kusirisin, Piyanut Kaewdoungtien, Sadudee Peerapornratana & Nattachai Srisawat

  4. Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Prit Kusirisin

  5. Department of Medicine, Central Chest Institute of Thailand, Nonthaburi, Thailand

    Peerapat Thanapongsatorn

  6. Academy of Science, Royal Society of Thailand, Bangkok, Thailand

    Nattachai Srisawat

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  1. Prit Kusirisin
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  2. Piyanut Kaewdoungtien
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  5. Nattachai Srisawat
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Correspondence to Nattachai Srisawat .

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Editors and Affiliations

  1. School of Medicine, University of Fortaleza, Fortaleza, Ceará, Brazil

    Geraldo Bezerra da Silva Junior

  2. Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan

    Masaomi Nangaku

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Kusirisin, P., Kaewdoungtien, P., Thanapongsatorn, P., Peerapornratana, S., Srisawat, N. (2022). Innovations in Intensive Care Nephrology. In: Bezerra da Silva Junior, G., Nangaku, M. (eds) Innovations in Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-031-11570-7_21

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