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Advances in the Synthesis and Applications of Self-Activated Fluorescent Nano- and Micro-Hydroxyapatite

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Research Topics in Bioactivity, Environment and Energy

Part of the book series: Engineering Materials ((ENG.MAT.))

Abstract

Hydroxyapatite (HA) is the major mineral phase of calcified tissues (i.e., bones and teeth), and the synthetic version of HA has several attractive properties for in vivo applications, ranging from hard tissue repair to drug/gene/protein delivery. In the last decades, HA has been used in combination with lanthanide ions, molecular fluorophores, or inorganic luminescent materials, for the potential use in fluorescence imaging, biosensing and theranostics as well as for the fabrication of optical devices. Recent studies have pointed to the susceptibility of HA to surface and structural defects, which end up impacting its electronic structure and improving its intrinsic fluorescent properties. This chapter highlights the main advances in the synthesis of activator- and dye-free fluorescent nano- and microparticles of HA, in addition to their application in the distinct technological fields and nanomedicine. The available information based on experimental and theoretical approaches about the role of the distinct defects that govern this intrinsic property is also summarized. Lastly, this chapter provides new insights into the design, fabrication and challenges for the further development of HA-based luminescent materials.

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Acknowledgements

The authors acknowledge the financial support of the following agencies: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Grants 164373/2020-9 and 141964/2018-9), and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant 2013/07296-2). Juan Andres acknowledges Universitat Jaume I for project UJI-B2019-30, and Ministerio de Ciencia, Innovacion y Universidades (Spain) project PGC2018- 094417-B-I00 for supporting this research financially.

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Authors and Affiliations

  1. GNANO – Nanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, University of São Paulo, São Carlos, SP, 89885-000, Brazil

    Thales Rafael Machado & Valtencir Zucolotto

  2. CDMF – Center for the Development of Functional Materials, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil

    Thales Rafael Machado, Jussara Soares da Silva & Elson Longo

  3. QIO – Inorganic and Organic Chemistry Department, Jaume I University, 12071, Castellón de la Plana, Spain

    Eloisa Cordoncillo & Héctor Beltrán-Mir

  4. QFA – Physical and Analytical Chemistry Department, Jaume I University, 12071, Castellón de la Plana, Spain

    Juan Andrés

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  1. Thales Rafael Machado
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Correspondence to Thales Rafael Machado .

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  1. Physics, Centro Brasileiro de Pesquisas Físicas, Rio de Janeiro, Brazil

    Carlton A. Taft

  2. Departamento de Quimica, Federal University of São Carlos, São Carlos, Brazil

    Sergio R. de Lazaro

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Machado, T.R. et al. (2022). Advances in the Synthesis and Applications of Self-Activated Fluorescent Nano- and Micro-Hydroxyapatite. In: Taft, C.A., de Lazaro, S.R. (eds) Research Topics in Bioactivity, Environment and Energy. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-031-07622-0_5

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