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Upper Gastrointestinal Motility, Disease and Potential of Stem Cell Therapy

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The Enteric Nervous System II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1383))

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Abstract

Many gastrointestinal motility disorders arise due to defects in the enteric nervous system. Achalasia and gastroparesis are two extremely debilitating digestive diseases of the upper gastrointestinal tract caused in part by damage or loss of the nitrergic neurons in the esophagus and stomach. Most current pharmacological and surgical interventions provide no long-term relief from symptoms, and none address the cause. Stem cell therapy, to replace the missing neurons and restore normal gut motility, is an attractive alternative therapy. However, there are a number of hurdles that must be overcome to bring this exciting research from the bench to the bedside.

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Authors and Affiliations

  1. Department of Anatomy & Physiology, University of Melbourne, Parkville, VIC, Australia

    Jesse Gardner-Russell, Jakob Kuriakose, Marlene M. Hao & Lincon A. Stamp

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  1. Jesse Gardner-Russell
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  2. Jakob Kuriakose
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  3. Marlene M. Hao
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  4. Lincon A. Stamp
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Correspondence to Lincon A. Stamp .

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  1. College of Medicine & Public Health Flinders Medical Centre, Adelaide, SA, Australia

    Nick J. Spencer

  2. College of Medicine & Public Health Flinders Medical Centre, Adelaide, SA, Australia

    Marcello Costa

  3. South Australian Health & Medical Research Institute, Adelaide, SA, Australia

    Stuart M. Brierley

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Gardner-Russell, J., Kuriakose, J., Hao, M.M., Stamp, L.A. (2022). Upper Gastrointestinal Motility, Disease and Potential of Stem Cell Therapy. In: Spencer, N.J., Costa, M., Brierley, S.M. (eds) The Enteric Nervous System II. Advances in Experimental Medicine and Biology, vol 1383. Springer, Cham. https://doi.org/10.1007/978-3-031-05843-1_29

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