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Roles for GADD45 in Development and Cancer

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Gadd45 Stress Sensor Genes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1360))

Abstract

The Growth Arrest and DNA Damage-inducible 45 (GADD45) family of proteins are critical stress sensors that mediate various cellular responses, including DNA repair, cell cycle arrest, and apoptosis. Here, we review current literature investigating GADD45 family members as they relate to normal development and carcinogenesis. We first describe how modulation of GADD45 in model organisms has facilitated our understanding of roles for GADD45 family members in development and homeostasis. We then review current literature exploring roles for GADD45 in human cancer, describing cancer-associated alterations in expression of GADD45 family members; tumor suppressive and tumor promoting functions attributed to GADD5; and roles for GADD45 in cancer therapy. In exploring roles for GADD45 in development, homeostasis, and carcinogenesis, we aim to provide an informational resource that both highlighst current knowledge on this topic while also noting key gaps in our understanding of the biology of GADD45 that may be filled in order to best guide the development of novel approaches to improve diagnosis, monitoring, and therapy of human malignancies.

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Authors and Affiliations

  1. Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA

    Kishan Patel, Mary Grace Murray & Kelly A. Whelan

  2. Department of Cancer & Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA

    Kelly A. Whelan

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  2. Mary Grace Murray
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  3. Kelly A. Whelan
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Correspondence to Kelly A. Whelan .

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Editors and Affiliations

  1. Fels Cancer Institute for Personalized Medicine, Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

    M. Raza Zaidi

  2. Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

    Dan A. Liebermann

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Patel, K., Murray, M.G., Whelan, K.A. (2022). Roles for GADD45 in Development and Cancer. In: Zaidi, M.R., Liebermann, D.A. (eds) Gadd45 Stress Sensor Genes. Advances in Experimental Medicine and Biology, vol 1360. Springer, Cham. https://doi.org/10.1007/978-3-030-94804-7_2

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