Abstract
The tricuspid valve regulates the blood flow between the right atrium and the right ventricle. Although it has long been deemed the forgotten valve, the interest in the tricuspid valve has significantly increased over the past five years. This is largely due to the emerging clinical awareness of the importance of tricuspid regurgitation, a valvular disease associated with blood back flow into the right atrium during systole. Many recent advancements have expanded the current understanding of tricuspid valve tissue biomechanics. However, many questions remain to be answered before long-term, durable therapeutics for tricuspid regurgitation can be provided to address several clinical challenges. This book chapter summarizes the recent investigations of tissue mechanics, collagen fiber architecture, and morphology for the subvalvular components of the tricuspid valve, and provides recommendation for future developments in this rising area of cardiovascular biomechanics.
We first met at the 8th World Congress of Biomechanics in 2018. During the conference, my postdoctoral fellow, Dr. Anju Babu (who is Dr. Holzapfel’s former advisee), presented our pioneering study on the layer-specific tricuspid valve tissue properties that was later well received by our community. Since then, I have been working closely with Dr. Holzapfel in a series of journal publications, including the developments of novel opto-mechanical instrument for quantifying load-dependent collagen fiber microstructures of collagenous tissues and the first tricuspid valve in silico model under the isogeometric analysis (IGA) framework for modeling healthy and diseased valve functions. I am fortunate to have such a wonderful mentor like Dr. Holzapfel in my early faculty career, and would like to express my gratitude to him for providing continuous support and advices that help my establishment of a strong and unique research program. Congratulations to Dr. Holzapfel on his 60th birthday!
Chung-Hao
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Acknowledgements
We would like to extend our well wishes to Dr. Gerhard A. Holzapfel for his 60th birthday, and congratulate him on his phenomenal accomplishments and prominent contributions to the soft tissue biomechanics community. Many current research advancements would remain elusive without his groundbreaking experimental, theoretical, and computational investigations. These beautifully-crafted studies from Dr. Holzapfel have provided endless inspirations, which, in addition to his invaluable perspective, have significantly impacted our research community and our laboratory.
We would also like to extend our sincere gratitude to the editors for providing this wonderful opportunity to share our contributions to the heart valve biomechanics community.
We also acknowledge the funding supports from the American Heart Association (AHA) Scientist Development Grant (SDG) Award (16SDG27760143) and the Presbyterian Health Foundation (PHF) Team Science Grant (C5122401) are greatly acknowledged. CHL was in part supported by the institutional start-up fund from the School of Aerospace and Mechanical Engineering, the IBEST-OUHSC Funding for Interdisciplinary Research, and the research funding from the Research Council at the University of Oklahoma. DWL and CJR were supported by the National Science Foundation Graduate Research Fellowship (GRF 2019254233 and 2020307284).
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Lee, CH., Laurence, D.W., Ross, C.J., Hudson, L.T. (2022). Advances in Experimental and Computational Biomechanics of the Tricuspid Heart Valve. In: Sommer, G., Li, K., Haspinger, D.C., Ogden, R.W. (eds) Solid (Bio)mechanics: Challenges of the Next Decade. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-030-92339-6_9
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