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Spatial Technologies: A Game Changer for Studying the Tumor Microenvironment

Handbook of Cancer and Immunology

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Abstract

Traditional immunohistochemistry (IHC) has long been considered the “gold standard” for tissue pathology diagnosis. However, the diagnostic and prognostic value of this technique is limited by a number of factors, the most important of which is that it only allows for the labeling of a single marker per tissue section. This limitation results in missed opportunities to obtain important prognostic and diagnostic information from patient samples. Recently, improvements in technologies such as multiplex immunohistochemistry and fluorescence-based in situ hybridization have enabled cell profiling at a spatial level, opening up new possibilities in research, diagnosis, and prognosis of different cancers.

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Authors and Affiliations

  1. National University of Singapore, Singapore, Singapore

    Ren Yuan LEE

  2. Singapore Thong Chai Medical Institution, Singapore, Singapore

    Ren Yuan LEE

  3. Bioinformatics Institute, Agency for Science, Technology and Research (A*Star), Singapore, Singapore

    Mai Chan LAU

  4. Singapore Immunology Network, Agency for Science, Technology and Research (A*Star), Singapore, Singapore

    Mai Chan LAU

  5. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Denise GOH, Felicia WEE, Jeffrey Chun Tatt LIM & Joe Poh Sheng YEONG

  6. Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore

    Joe Poh Sheng YEONG

  7. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

    Joe Poh Sheng YEONG

  8. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Joe Poh Sheng YEONG

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  5. Jeffrey Chun Tatt LIM
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  6. Joe Poh Sheng YEONG
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Correspondence to Joe Poh Sheng YEONG .

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  1. Division of Clinical Immunology, Karolinska University Hospital, Huddinge, Sweden

    Nima Rezaei

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LEE, R.Y., LAU, M.C., GOH, D., WEE, F., LIM, J.C.T., YEONG, J.P.S. (2023). Spatial Technologies: A Game Changer for Studying the Tumor Microenvironment. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_96-2

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  • DOI: https://doi.org/10.1007/978-3-030-80962-1_96-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-80962-1

  • Online ISBN: 978-3-030-80962-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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  1. Latest

    Spatial Technologies: A Game Changer for Studying the Tumor Microenvironment
    Published:
    14 May 2023

    DOI: https://doi.org/10.1007/978-3-030-80962-1_96-2

  2. Original

    Spatial Technologies: A Game Changer for Studying the Tumor Microenvironment
    Published:
    27 April 2023

    DOI: https://doi.org/10.1007/978-3-030-80962-1_96-1

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