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Metabolic Regulation: Insulin Secretion and Action

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5-HT2B Receptors

Part of the book series: The Receptors ((REC,volume 35))

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Abstract

The physiological functions of peripheral serotonin (5-hydroxytryptamine, 5-HT) has been highlighted recently, in its role in regulating energy metabolism in various metabolic organs. 5-HT exerts its biological action through its binding to 5-HT receptor (HTR) in target tissues. Of the 14 HTRs identified to date, HTR2B plays a pivotal role in regulating glucose and lipid metabolism in pancreatic β-cells, adipocytes, and hepatocytes. HTR2B has been shown to regulate insulin secretion and cell proliferation in pancreatic β-cells, to promote lipolysis in adipocytes, and to regulate gluconeogenesis and glucose uptake in hepatocytes. This chapter describes the physiological roles of HTR2B and the molecular mechanism underlying its regulation of energy metabolism in various peripheral organs.

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Abbreviations

BAT:

Brown adipose tissue

FFAs:

Free fatty acids

HTR:

5-HT receptor

5-HTP:

5-Hydroxytryptophan

JAK2:

Janus kinase 2

KO:

Knockout

AMS:

α-Methyl serotonin maleate

(MEK)1/2:

Mitogen-activated protein kinase kinase

PI3K:

Phosphoinositide 3-kinase

PRLR:

Prolactin receptor

5-HT:

5-hydroxytryptamine

STAT5:

Signal transducer and activator of transcription 5

TPH1:

Tryptophan hydroxylase-1

UCP1:

Uncoupling protein 1

WAT:

White adipose tissue

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Author information

Authors and Affiliations

  1. Graduate School of Medical Science and Engineering, KAIST, Daejeon, South Korea

    Wonsuk Choi, Joon Ho Moon & Hail Kim

Authors
  1. Wonsuk Choi
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  2. Joon Ho Moon
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  3. Hail Kim
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Corresponding author

Correspondence to Hail Kim .

Editor information

Editors and Affiliations

  1. Inserm, U1270, Institut du Fer a Moulin, Paris, France

    Luc Maroteaux

  2. Pharmacology, Strasbourg Medical school, Strasbourg, France

    Laurent Monassier

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Choi, W., Moon, J.H., Kim, H. (2021). Metabolic Regulation: Insulin Secretion and Action. In: Maroteaux, L., Monassier, L. (eds) 5-HT2B Receptors. The Receptors, vol 35. Springer, Cham. https://doi.org/10.1007/978-3-030-55920-5_15

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