Abstract
microRNAs (miRNAs) have emerged as key regulators of metabolic processes, playing critical roles in maintaining energy balance and metabolic homeostasis. Dysregulation of miRNAs may contribute to metabolic abnormalities since they play pivotal roles in body fat accumulation, obesity, and obesity-related diseases by directly affecting the status and functions of adipose tissue, pancreas, liver, and muscle. The discovery of circulating miRNAs highlighted their potential as either endocrine signaling molecules or disease indicators. This chapter aims to provide recent findings concerning the contribution of miRNAs to obesity and obesity-related morbid conditions.
This chapter is an update from the previously published article by Iacomino G, Siani A. Role of microRNAs in obesity and obesity-related diseases. Genes Nutr 12, 23 (2017). https://doi.org/10.1186/s12263-017-0577-z.
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Abbreviations
- ABCA1:
-
ATP-binding cassette transporter 1
- AGO:
-
Argonaute
- Apo:
-
Apolipoprotein
- BMI:
-
Body mass index
- BMPs:
-
Bone morphogenetic proteins
- C/EBPs:
-
CCAAT/enhancer-binding proteins
- c-miRNAs:
-
Circulating miRNAs
- Creb1:
-
cAMP-Responsive element binding protein 1
- ERK:
-
Extracellular signal-regulated kinases
- FABP4:
-
Fatty acid-binding protein 4
- FASN:
-
Fatty acid synthase
- FGF21:
-
Fibroblast growth factor 21
- Foxa2:
-
Forkhead box protein A2
- FOXO1:
-
Forkhead box O1
- HbA1c:
-
Glycated hemoglobin A1c
- HNF:
-
Hepatocyte nuclear factor
- HOMA-IR score:
-
Homeostatic model assessment for insulin resistance
- INSR:
-
Insulin receptor
- IRS-1:
-
Insulin receptor substrate 1
- LETFs:
-
Liver-enriched transcription factors
- LXRα :
-
Liver X receptor α
- miRNAs:
-
microRNAs
- ncRNAs:
-
Small noncoding RNAs
- N-CoR:
-
Nuclear receptor corepressor
- Ngn3:
-
Neurogenin3
- NGS:
-
Next-generation sequencing
- NOD:
-
Nonobese diabetic mice
- NPM-1:
-
Nucleophosmin-1
- Pdx1:
-
Pancreatic and duodenal homeobox 1
- PEPCK:
-
Phosphoenolpyruvate carboxykinase
- PI3K:
-
Insulin/phosphoinositide-3 kinase
- PPARγ:
-
Proliferator-activated receptor-γ
- RB:
-
Retinoblastoma susceptibility protein
- RISCs:
-
RNA-induced silencing complexes
- RNAseq:
-
RNA sequencing
- RXRα:
-
Retinoid X receptor alpha
- SFA:
-
Saturated fatty acids
- SHIP1:
-
SH2 (Src homology 2)-containing inositol phosphatase-1
- SIRT1:
-
Sirtuin 1
- SMRT:
-
Silencing mediator for retinoid and thyroid hormone receptors
- SREBP1:
-
Sterol regulatory element-binding protein
- T2D:
-
Type-2 diabetes
- TGF-β:
-
Transforming growth factor beta
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Iacomino, G., Lauria, F., Venezia, A., Iannaccone, N., Russo, P., Siani, A. (2020). microRNAs in Obesity and Metabolic Diseases. In: Faintuch, J., Faintuch, S. (eds) Obesity and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-53370-0_6
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