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Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline During Normal and Pathological Brain Aging

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Reviews on New Drug Targets in Age-Related Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1260))

Abstract

Research in animals and humans has indicated that polyphenols can delay the age-related decline in learning, memory and neurodegenerative diseases. Among the polyphenols, berry phenolics have extensive beneficial effects because of their antioxidant and anti-inflammatory properties. Long-term consumption of grapes results in accumulation of polyphenols in the brain, which modulates cell-signalling pathways and neutralises the redox imbalance in the aging brain. Here we review the in vivo and in vitro evidence for considering grape-derived polyphenolics, the flavonoids- catechins, epicatechin, anthocyanidin, and quercetin, and non-flavonoids-gallic acid and resveratrol, as effective dietary sources to facilitate cognition in adults and lessen the decline in the old and pathogenic states, Alzheimer’s and Parkinson’s disease. Furthermore, a combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.

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Acknowledgements

We thank all the lab members for their support in reading the manuscript. We apologize to research groups for not mentioning their studies due to space constraints. Financial support for our studies cited in this article has been through research grants from the Indian Council of Medical Research (ICMR, Referral No.54/9/CFP/GER/2011/NCD-II, dt.30.04.2012), New Delhi and the Promotion of University Research and Scientific Excellence (PURSE)-Department of Science and Technology (DST, Referral No. SR/59/Z-23/2010/38) dt.27.06.2011), New Delhi, India.

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  1. Laboratory of Gerontology, Department of Zoology, Bangalore University, Bangalore, India

    S. Asha Devi & Anudita Chamoli

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  1. S. Asha Devi
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  2. Anudita Chamoli
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Correspondence to S. Asha Devi .

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  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Devi, S.A., Chamoli, A. (2020). Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline During Normal and Pathological Brain Aging. In: Guest, P. (eds) Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1260. Springer, Cham. https://doi.org/10.1007/978-3-030-42667-5_7

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