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The Role of Hyaluronic Acid in Tissue Engineering

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Polysaccharides of Microbial Origin

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Abstract

Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many parts of the body. It is a material of increasing importance to biomaterial science and is finding applications in diverse areas ranging from tissue culture scaffolds to cosmetic materials. This chapter considers the recent research on the role of HA in tissue engineering and the importance of HA as an immunomodulatory material. The chemical modifications and processing methods employed to produce HA-modified tissue scaffolds are discussed, thus giving a better understanding of the structure-function-property relationships that influence scaffold performance, tissue growth, and regeneration. The chapter concludes with a vision for the future of HA in tissue-engineered constructs.

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Acknowledgments

The authors would like to thank the financial support provided by following funding bodies:

Irish Research Council (GOIPG/2015/3577); European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 801165, with cofunding through SSPC by its funding body, Science Foundation Ireland, grant no. 112/RC/2275_P2.

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Authors and Affiliations

  1. School of Engineering, University of Limerick, Limerick, Ireland

    Maurice N. Collins, Fernanda Zamboni, Aleksandra Serafin, Guang Ren, A. V. Thanusha & Mario Culebras

  2. Stokes Laboratories, Bernal Institute, University of Limerick, Limerick, Ireland

    Maurice N. Collins, Fernanda Zamboni, Aleksandra Serafin, Guang Ren, A. V. Thanusha & Mario Culebras

  3. Health Research Institute, University of Limeric, Limerick, Ireland

    Maurice N. Collins & Fernanda Zamboni

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  1. Maurice N. Collins
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  2. Fernanda Zamboni
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  5. A. V. Thanusha
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  6. Mario Culebras
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Correspondence to Maurice N. Collins .

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  1. 3Bs Research Grp, Zona Indus da Gan, University of Minho, BARCO GMR, Portugal

    Joaquim Oliveira

  2. 3Bs Research Grp, Zona Indus da Gan, University of Minho, BARCO GMR, Portugal

    Hajer Radhouani

  3. 3Bs Research Grp, Zona Indus da Gan, University of Minho, BARCO GMR, Portugal

    Rui L. Reis

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Collins, M.N., Zamboni, F., Serafin, A., Ren, G., Thanusha, A.V., Culebras, M. (2021). The Role of Hyaluronic Acid in Tissue Engineering. In: Oliveira, J., Radhouani, H., Reis, R.L. (eds) Polysaccharides of Microbial Origin. Springer, Cham. https://doi.org/10.1007/978-3-030-35734-4_56-1

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