Abstract
A very wide range of homeostatic processes is disturbed in cancer. These are visible at patient, lesion, tissue, and cellular levels across all body systems, including in all body fluids, and are increasingly understood at molecular level, providing many opportunities to research molecular therapeutic targets. This chapter introduces and contextualises most of the processes currently understood as of importance to the biology of cancer: many of these understandings are comparatively new; some are speculative. Astonishing advances in technology enable vast amounts of information from a single patient – even a single cell, posing challenges in interpretation of such “big data”. Nevertheless, it is upon speculations around the meaning of this information, and the application of strict scientific method, that progress in cancer prevention and management depend. Prudence is required not to overplay the clinical applicability of much current research.
Some contents of this Chapter are reused under licence 4636580828816. These are based on previously published work in “Squamous Cell Carcinoma- Molecular Therapeutic Targets” published by Springer Nature
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Johnson, N.W. (2020). Cancer Biology and Carcinogenesis: Fundamental Biological Processes and How They Are Deranged in Oral Cancer. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_29
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