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The significant role of mast cells in cancer

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Abstract

Mast cells (MC) are a bone marrow-derived, long-lived, heterogeneous cellular population that function both as positive and negative regulators of immune responses. They are arguably the most productive chemical factory in the body and influence other cells through both soluble mediators and cell-to-cell interaction. MC are commonly seen in various tumors and have been attributed alternatively with tumor rejection or tumor promotion. Tumor-infiltrating MC are derived both from sentinel and recruited progenitor cells. MC can directly influence tumor cell proliferation and invasion but also help tumors indirectly by organizing its microenvironment and modulating immune responses to tumor cells. Best known for orchestrating inflammation and angiogenesis, the role of MC in shaping adaptive immune responses has become a focus of recent investigations. MC mobilize T cells and antigen-presenting dendritic cells. They function as intermediaries in regulatory T cells (Treg)-induced tolerance but can also modify or reverse Treg-suppressive properties. The central role of MC in the control of innate and adaptive immunity endows them with the ability to tune the nature of host responses to cancer and ultimately influence the outcome of disease and fate of the cancer patient.

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Authors and Affiliations

  1. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, 303 East Superior Street, Lurie 3-250, Chicago, IL, 60611, USA

    Khashayarsha Khazaie, Nichole R. Blatner, Mohammad Wasim Khan, Elias Gounaris, Kristen Dennis, Fu-Nien Tsai, Matthew J. Strouch, Eric Cheon, Joseph D. Phillips & David J. Bentrem

  2. Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue, Chicago, IL, 60612, USA

    Khashayarsha Khazaie & David J. Bentrem

  3. Department of Microbiology-Immunology, Northwestern University, 303 East Superior Street, 3-111 Lurie, Chicago, IL, 60611-3015, USA

    Khashayarsha Khazaie

  4. Department of Surgery, Northwestern University, 676 N Saint Clair, Suite 650, Chicago, IL, 60611, USA

    Matthew J. Strouch, Eric Cheon, Joseph D. Phillips & David J. Bentrem

  5. Department of Medicine, Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, 303 East Superior Street, Lurie 3-250, Chicago, IL, 60611, USA

    Khashayarsha Khazaie, Nichole R. Blatner, Mohammad Wasim Khan, Elias Gounaris, Kristen Dennis & Fu-Nien Tsai

  6. Department of Medicine, Section of Rheumatology, University of Chicago, 5841 S. Maryland Avenue, MC 0930, Chicago, IL, 60637, USA

    Fotini Gounari

  7. Division of Translational Immunology, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Andreas Bonertz

  8. Division of Translational Immunology, Northwestern University, Feinberg School of Medicine, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Philipp Beckhove

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  1. Khashayarsha Khazaie
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Correspondence to Khashayarsha Khazaie.

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This article is supported by the Circle of Service Foundation Inc. SP0005882 RH Lurie Comprehensive Cancer Center and ACS/RSG, LIB-113422 RSG and NIH/NCI R01-CA1045-47-05 (KK), NIH/NIAID, RO1 AI059676 & ACS/RSG, LIB-113428 (FG), IDP Foundation and the Nathan & Isabel Miller Foundation (JP), and Malkin Scholars Program Cancer Research Award (KLD).

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Khazaie, K., Blatner, N.R., Khan, M.W. et al. The significant role of mast cells in cancer. Cancer Metastasis Rev 30, 45–60 (2011). https://doi.org/10.1007/s10555-011-9286-z

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