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Giant Cell Arteritis

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Genetics of Rare Autoimmune Diseases

Part of the book series: Rare Diseases of the Immune System ((RDIS))

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Abstract

Giant cell arteritis (GCA) is an immune-mediated large-vessel vasculitis with a complex etiology in which a cross talk between environmental and genetic factors may affect its susceptibility and phenotypic expression. During the last decades, a large number of candidate gene studies explored the genetic component of GCA. However, most genetic associations were inconsistent due to reduced sample sizes and lack of replication in independent populations. More recently, the establishment of international consortia and the use of the novel omic technologies have given a boost to the current knowledge of the pathological mechanisms behind GCA. In this chapter, we will give an updated overview of the recent insights into the genetic basis of GCA.

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Authors and Affiliations

  1. Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada, Spain

    Francisco David Carmona

  2. Centro de Investigación Biomédica (CIBM), Universidad de Granada, Parque Tecnológico Ciencias de la Salud, Granada, Spain

    Francisco David Carmona

  3. Instituto de Parasitología y Biomedicina ‘López-Neyra’, IPBLN-CSIC, Granada, Spain

    Javier Martín

  4. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain

    Miguel A. González-Gay

  5. School of Medicine, University of Cantabria, Santander, Spain

    Miguel A. González-Gay

  6. Cardiovascular Pathophysiology and Genomics Research Unit, Faculty of Health Sciences, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa

    Miguel A. González-Gay

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  1. Francisco David Carmona
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  2. Javier Martín
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  3. Miguel A. González-Gay
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Correspondence to Francisco David Carmona .

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Editors and Affiliations

  1. Institute of Parasitology and Biomedicine, Lopez-Neyra, CSIC, Granada, Spain

    Javier Martín

  2. Department of Genetics, University of Granada, Armilla, Granada, Spain

    Francisco David Carmona

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Carmona, F.D., Martín, J., González-Gay, M.A. (2019). Giant Cell Arteritis. In: Martín, J., Carmona, F. (eds) Genetics of Rare Autoimmune Diseases. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-030-03934-9_7

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