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Biomechanics and Modeling of Tissue-Engineered Heart Valves

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Advances in Heart Valve Biomechanics

Abstract

Heart valve tissue engineering (HVTE) is a promising technique to overcome the limitations of currently available heart valve prostheses. However, before clinical use, still several challenges need to be overcome. The functionality of the developed replacements is determined by their biomechanical properties and, ultimately, by their collagen architecture. Unfortunately, current techniques are often not able to induce a physiological tissue remodeling, which compromises the long-term functionality. Therefore, a deeper understanding of the process of tissue remodeling is required to optimize the phenomena involved via improving the current HVTE approaches. Computational simulations can help in this process, being a valuable and versatile tool to predict and understand experimental results. This chapter first describes the similarities and differences in functionality and biomechanical properties between native and tissue-engineered heart valves. Secondly, the current status of computational models for collagen remodeling is addressed and, finally, future directions and implications for HVTE are suggested.

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Abbreviations

ECM:

Extracellular matrix

HVTE:

Heart valve tissue engineering

SF:

Stress fiber

TE:

Tissue engineering

TEHV:

Tissue-engineered heart valves

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Author notes

  1. T. Ristori and A. J. van Kelle contributed equally to this work.

Authors and Affiliations

  1. Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

    T. Ristori, A. J. van Kelle, F. P. T. Baaijens & S. Loerakker

  2. Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands

    T. Ristori, A. J. van Kelle, F. P. T. Baaijens & S. Loerakker

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  1. T. Ristori
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  3. F. P. T. Baaijens
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Editors and Affiliations

  1. The Oden Institute and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA

    Michael S. Sacks

  2. The Department of Bioengineering, The University of Texas at Arlington, Arlington, TX, USA

    Jun Liao

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Ristori, T., van Kelle, A.J., Baaijens, F.P.T., Loerakker, S. (2018). Biomechanics and Modeling of Tissue-Engineered Heart Valves. In: Sacks, M., Liao, J. (eds) Advances in Heart Valve Biomechanics. Springer, Cham. https://doi.org/10.1007/978-3-030-01993-8_16

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