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Synthesis of Gold Nanoparticle: Peptide–Drug Conjugates for Targeted Drug Delivery

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Drug Delivery Systems

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2059))

Abstract

Peptide–drug conjugates (PDCs) are being developed for the targeted delivery of drugs to cancer cells. Several approaches are being followed to enhance their stability in biological solutions. Here we describe an effective method to easily couple PDCs to polyethylene-coated gold nanoparticles. We also outline analytical methods to validate the coupling and assays to measure the stability and cytotoxic efficacy of the conjugates.

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Authors and Affiliations

  1. Department of Biological Engineering, College of Engineering, Konkuk University, Seoul, Republic of Korea

    K. Kalishwaralal

  2. Department of Chemical Engineering (Biotechnology and Materials), Ariel University, Ariel, Israel

    K. Kalishwaralal, G. Luboshits & M. A. Firer

  3. Ariel Center for Applied Cancer Research, Ariel University, Ariel, Israel

    G. Luboshits & M. A. Firer

  4. Adelson School of Medicine, Ariel University, Ariel, Israel

    M. A. Firer

Authors
  1. K. Kalishwaralal
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  2. G. Luboshits
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  3. M. A. Firer
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Corresponding author

Correspondence to M. A. Firer .

Editor information

Editors and Affiliations

  1. Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain

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Kalishwaralal, K., Luboshits, G., Firer, M.A. (2020). Synthesis of Gold Nanoparticle: Peptide–Drug Conjugates for Targeted Drug Delivery. In: Jain, K. (eds) Drug Delivery Systems. Methods in Molecular Biology, vol 2059. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9798-5_6

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  • DOI: https://doi.org/10.1007/978-1-4939-9798-5_6

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9797-8

  • Online ISBN: 978-1-4939-9798-5

  • eBook Packages: Springer Protocols

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