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Cell-Penetrating Peptides as Theranostics Against Impaired Blood-Brain Barrier Permeability: Implications for Pathogenesis and Therapeutic Treatment of Neurodegenerative Disease

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Blood-Brain Barrier

Part of the book series: Neuromethods ((NM,volume 142))

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Abstract

Over the past few decades, the blood-brain barrier (BBB) has been acknowledged as the prime defense mechanism for the brain against exterior deadly substances. This dynamic barrier, which is primarily comprised of precisely arranged, specialized endothelial cells, astrocytes, and pericytes, not only prevents the brain interstitial fluid from mixing with the components of blood but also maintains a delicate balance between central nervous system (CNS) and blood circulatory system by transferring essential substances across the BBB. Thus, any dysfunction in the BBB activity leads to several neuroinflammatory disorders such as Alzheimer’s, Parkinson’s, and prion-related diseases. The risk posed by such neurodegenerative diseases has become the foremost public health concern worldwide because of the lack of BBB-permeable therapeutic agents. This points to the need for studying the characteristic traits of various BBB-permeable cell-penetrating peptides (CPPs), which have emerged as a potential drug delivery tool in CNS therapeutics. In this chapter, we would like to review the benefits of employing nuclear magnetic resonance (NMR) techniques toward understanding the structural, functional, and dynamic behavior of CPPs at the molecular level, during their interaction with BBB-model membranes. We conclude that CPPs can be utilized for developing promising therapeutic drugs against CNS diseases.

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Acknowledgments

This research was supported by Institutional fund (Plan Project-II), CSIR, and Indo-Swedish (DST-VR) research grant. S.B. thanks CSIR-UGC, Govt. of India, for senior research fellowship. A.B. thanks Prof. Kalipada Pahan, Rush University Medical Center, for in vivo data.

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  1. Department of Biophysics, Bose Institute, Kolkata, India

    Swapna Bera & Anirban Bhunia

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  1. Swapna Bera
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Correspondence to Anirban Bhunia .

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  1. Department of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    Tatiana Barichello

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Bera, S., Bhunia, A. (2019). Cell-Penetrating Peptides as Theranostics Against Impaired Blood-Brain Barrier Permeability: Implications for Pathogenesis and Therapeutic Treatment of Neurodegenerative Disease. In: Barichello, T. (eds) Blood-Brain Barrier. Neuromethods, vol 142. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8946-1_7

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  • DOI: https://doi.org/10.1007/978-1-4939-8946-1_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8945-4

  • Online ISBN: 978-1-4939-8946-1

  • eBook Packages: Springer Protocols

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