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Nanotoxicology

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In Vitro Toxicology Systems

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

This chapter highlights the specific challenges related to in vitro toxicity testing of nanomaterials. The difficulties presented are related to the very complex behavior of nanomaterials during the in vitro tests, namely, dissolution, aggregation, sedimentation, and formation of a protein corona. All these aspects modify the physicochemical characteristics of nanomaterials and their transport to the cell layer and cellular uptake and affect the effective cellular dose and response. The article underlines the necessity, for the toxicologist, to characterize and control all these features to be able to provide a reliable toxicity result.

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Notes

  1. 1.

    COMMISSION RECOMMENDATION of 18 October 2011 on the definition of nanomaterial (2011/696/EU). See http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:201. 1:275:0038:0040:EN:PDF online.

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Authors and Affiliations

  1. Nanobiosciences Unit, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, VA, Italy

    Agnieszka Kinsner-Ovaskainen, Pascal Colpo, Jessica Ponti & François Rossi

Authors
  1. Agnieszka Kinsner-Ovaskainen
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  2. Pascal Colpo
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  3. Jessica Ponti
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  4. François Rossi
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Correspondence to François Rossi .

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Editors and Affiliations

  1. European Commission Joint Research Centre, Ispra, Varese, Italy

    Anna Bal-Price

  2. Innsbruck Medical University, Innsbruck, Austria

    Paul Jennings

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Kinsner-Ovaskainen, A., Colpo, P., Ponti, J., Rossi, F. (2014). Nanotoxicology. In: Bal-Price, A., Jennings, P. (eds) In Vitro Toxicology Systems. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0521-8_21

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  • DOI: https://doi.org/10.1007/978-1-4939-0521-8_21

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