In Vitro Toxicology Systems

  • Anna Bal-Price
  • Paul Jennings

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Systemic Organ Toxicity

    1. Front Matter
      Pages 25-25
    2. Jan G. Hengstler, Seddik Hammad, Ahmed Ghallab, Raymond Reif, Patricio Godoy
      Pages 27-44
    3. Vaibhav Shinde, Umesh Chaudhari, Isaia Sotiriadou, Jürgen Hescheler, Agapios Sachinidis
      Pages 45-77
    4. Paul Jennings, Lydia Aschauer, Anja Wilmes, Gerhard Gstraunthaler
      Pages 79-101
    5. Oliver H. Wittekindt
      Pages 103-121
  4. Neurotoxicity

    1. Front Matter
      Pages 123-123
    2. Anna Bal-Price, Helena T. Hogberg
      Pages 125-146
    3. Anaelle Fabulas-Da Costa, Christophe Landry, Lucie Dehouck, Emmanuel Sevin, Marie-Pierre Dehouck, Roméo Cecchelli et al.
      Pages 147-166
  5. Sensory Organ Models

    1. Front Matter
      Pages 167-167
    2. Chantra Eskes, Erwin van Vliet, Michael Schäffer, Valérie Zuang
      Pages 169-197
    3. Jochen Schacht, Michael G. Leitner
      Pages 199-222
  6. Other Organs and Aspects

    1. Front Matter
      Pages 223-223
    2. David Basketter, Silvia Casati
      Pages 225-239
    3. Thomas Hartung
      Pages 241-267
    4. Giovanna Lazzari, Cesare Galli
      Pages 269-284
    5. Patrick J. Devine
      Pages 285-306
    6. Federica Madia, Pascal Phrakonkham, Raffaella Corvi
      Pages 307-332

About this book

Introduction

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches.

Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.

Keywords

Cell culture Chemical testing Drug safety assessment Human toxicity prediction Pharmaceuticals Predictive systems Toxicity testing regimes

Editors and affiliations

  • Anna Bal-Price
    • 1
  • Paul Jennings
    • 2
  1. 1.European Commission Joint Research CentreIspraItaly
  2. 2.Innsbruck Medical UniversityInnsbruckAustria

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-0521-8
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-0520-1
  • Online ISBN 978-1-4939-0521-8
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • About this book