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Primary and Adjuvant Radiation Therapy in the Management of Penile Cancer

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Management of Penile Cancer

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Abstract

Penile cancer is an uncommon male cancer that has historically been treated with penectomy. Although penectomy provides a high local control rate, it is also associated with significant psychosocial side effects. This has resulted in growing interest in an organ-preserving approach whenever possible. This chapter will focus on the use of radiation therapy in the treatment of penile cancer, especially in the setting of organ preservation. The use of brachytherapy as well as external beam radiation therapy will be covered. Patients undergoing interstitial brachytherapy for penile cancer achieve local control and organ preservation in the range of 70–85 % and cause-specific survival in the range of 84–92 %. The use of external beam radiation therapy produces local control rates in the range of 50–70 % and penile preservation in the range of 55–66 %. The cause-specific survival ranges from 66 to 99 %. In this chapter, we will review the pertinent literature concerning radiation therapy techniques in the treatment of penile cancer.

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Abbreviations

BT:

Brachytherapy

CSS:

Cause-specific survival/cancer-specific survival

DFS:

Disease-free survival

EBRT:

External beam radiation therapy

HDR:

High dose rate

IMRT:

Intensity-modulated radiation therapy

LC:

Local control

LDR:

Low dose rate

LN:

Lymph node

OS:

Overall survival

PDR:

Pulsed dose rate

SCC:

Squamous cell carcinoma

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Authors and Affiliations

  1. Department of Radiation Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 800 NE 10th St., OKCC L100, Oklahoma City, OK, 73104, USA

    Özer Algan MD

  2. Department of Radiation Oncology, Cancer Center for the Southern Interior, British Columbia Cancer Agency, University of British Columbia, 399 Royal Avenue, Kelowna, BC, Canada

    Juanita Crook MD, FRCPC

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  1. Özer Algan MD
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Correspondence to Özer Algan MD .

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  1. Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Daniel J. Culkin

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Algan, Ö., Crook, J. (2014). Primary and Adjuvant Radiation Therapy in the Management of Penile Cancer. In: Culkin, D. (eds) Management of Penile Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0461-7_11

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