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Human Cerebral Blood Flow and Traumatic Brain Injury

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Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

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Abstract

The measurement of cerebral blood flow (CBF) in the clinical setting first began in earnest during the 1940s by Kety and Schmidt. By utilizing an inert diffusible gas (nitrous oxide), measuring it in arterial and jugular venous blood, and applying the Fick principle of blood flow determination they were able to calculate a global rate of CBF of mL/100 g/min. Kety–Schmidt-based CBF measurements evolved over the next 2 decades by the substitution of radioactive gases for nitrous oxide.

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Author information

Authors and Affiliations

  1. Departments of Neurosurgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 18-266 Semel, 957039, Los Angeles, CA, USA

    David A. Hovda

  2. Departments of Neurosurgery and of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Thomas C. Glenn

Authors
  1. David A. Hovda
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  2. Thomas C. Glenn
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Correspondence to David A. Hovda .

Editor information

Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Hovda, D.A., Glenn, T.C. (2014). Human Cerebral Blood Flow and Traumatic Brain Injury. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_3

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  • DOI: https://doi.org/10.1007/978-1-4614-8690-9_3

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