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Cell Cycle Control and Growth Factor Systems in Metastasis

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Experimental and Clinical Metastasis

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Abstract

Cancer remains a leading cause of death in industrialized countries despite advances in the detection and treatment of this disease (Heron et al., Natl Vital Stat Rep 57:1–134, 2009). Traditional models of cancer posit that neoplastic cells arise through the sequential accumulation of genetic mutations leading to independent and uninhibited replication, the evasion of apoptosis, sustained angiogenesis, and ultimately, invasion and metastasis. The latter is of particular clinical significance as metastasis is the leading cause of cancer related death (Pantel and Brakenhoff 2004; Colotta et al. 2009; Wu and Zhou 2009; Sica et al. 2008).

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Authors and Affiliations

  1. Department of Surgery, McGill University, Montreal, QC, Canada

    Jonathan Cools-Lartigue MD & Jonathan Spicer

Authors
  1. Jonathan Cools-Lartigue MD
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  2. Jonathan Spicer
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Correspondence to Jonathan Cools-Lartigue MD .

Editor information

Editors and Affiliations

  1. Centre for Genomic Regulation, N/A, Barcelona, N/A, Spain

    Julia V. Burnier

  2. , Ophthalmology, Pathology, Medicine & Onc, McGill University Health Centre, University Street 3775, Montreal, H3A 2B4, Québec, Canada

    Miguel N. Burnier, Jr.

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Cools-Lartigue, J., Spicer, J. (2013). Cell Cycle Control and Growth Factor Systems in Metastasis. In: Burnier, J., Burnier, Jr., M. (eds) Experimental and Clinical Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3685-0_7

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