Experimental and Clinical Metastasis

A Comprehensive Review

  • Julia V. Burnier
  • Miguel N. Burnier, Jr.

Table of contents

  1. Front Matter
    Pages 1-1
  2. Introduction to Metastatic Diseases

    1. Front Matter
      Pages 1-1
    2. Julia V. Burnier, Miguel N. Burnier Jr.
      Pages 3-10
  3. Gene Properties of Metastatic Cells

    1. Front Matter
      Pages 29-29
    2. Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins
      Pages 31-36
    3. Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins
      Pages 37-47
    4. Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins
      Pages 49-52
    5. Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins
      Pages 53-53
  4. Molecular Mechanisms of Tumor Growth and Spread

    1. Front Matter
      Pages 55-55
    2. Jonathan Cools-Lartigue, Jonathan Spicer
      Pages 57-78
    3. Karen J. Lefebvre, Sarah Assadian, Wissal El-Assaad, Jose G. Teodoro
      Pages 79-99
    4. Jeremy Dupaul-Chicoine, Maya Saleh
      Pages 101-127
    5. Nicholas R. Bertos, Morag Park
      Pages 129-147
  5. Methods of Tumor Dissemination

    1. Front Matter
      Pages 149-149
    2. Patricia Rusa Pereira
      Pages 151-164
    3. Alexandre Nakao Odashiro
      Pages 165-176
    4. Bruno F. Fernandes
      Pages 177-190
    5. Abelardo A. Rodríguez-Reyes
      Pages 191-198
  6. Animal Models of Metastasis

    1. Front Matter
      Pages 199-199
    2. Patrick T. Logan
      Pages 201-218
    3. William J. Muller, Ian Swanson
      Pages 227-236
    4. Patrick T. Logan
      Pages 237-247
  7. Diagnosis and Treatment of Metastatic Disease

    1. Front Matter
      Pages 249-249
    2. Dawn Russell-Hermanns
      Pages 251-273
    3. Alexandre Nakao Odashiro
      Pages 275-278
    4. Mohib Wadie Morcos
      Pages 279-284
    5. Dominique Fausto de Souza
      Pages 285-298
    6. Catalin Mihalcioiu
      Pages 299-318
    7. Ari-Nareg Meguerditchian, Sarkis H. Meterissian, Marissa Grace Ponzo
      Pages 319-350
    8. Fabio Luis Cury, George Shenouda
      Pages 351-379
    9. Peter Metrakos, Eli Kakiashvili, Murad Aljiffry, Mazen Hassanain, Prosanto Chaudhury
      Pages 381-399
  8. Targeted Therapy for Metastatic Disease

    1. Front Matter
      Pages 401-401
    2. Dana Faingold, Dawn Russell-Hermanns, Silvin Bakalian
      Pages 403-444
    3. Dana Faingold, Silvin Bakalian, Dawn S. Russell-Hermanns
      Pages 445-469
  9. Back Matter
    Pages 454-454

About this book


The primary cause of death related to cancers can be traced back to metastases, originated from cancer cells. The presence of metastatic disease, the spread of cancer cells, is the most important prognostic and survival factor in patients with cancer. Although treatment of the primary tumor is well established and usually results in local control, treating metastatic disease is a much more daunting task. At diagnosis, few patients present with clinically detectable metastatic lesions regardless of the clinical prognostic factor. Clinical trials assessing potential therapeutic agents are important in order to define the best specific treatment for a particular patient, which are the basis for patient-oriented research that eventually lead to personalized medicine.

This volume aims to comprehensively present the latest research and information about metastasis. Understanding the mechanisms underlying the metastatic phenomenon could have vast implications for the large number of patients who are at a high risk for the development of metastasis.


Cancer Disease Metastasis Metastatic Research

Editors and affiliations

  • Julia V. Burnier
    • 1
  • Miguel N. Burnier, Jr.
    • 2
  1. 1.Centre for Genomic RegulationBarcelonaSpain
  2. 2., Ophthalmology, Pathology, Medicine & OncMcGill University Health CentreMontrealCanada

Bibliographic information