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Advances in Rapid Sex-Steroid Action

New Challenges and New Chances in Breast and Prostate Cancers

  • Book
  • © 2012

Overview

Editors:
  1. Gabriella Castoria

    1. University of Naples, Naples, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Antimo Migliaccio

    1. Department of Pathology, II University of Naples, Naples, Italy

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    You can also search for this editor in PubMed   Google Scholar

  • This volume provides an up-to-date review of recently discovered rapid action of sex steroid hormones

  • Recent years have seen the discovery of significant numbers of master proteins in breast and prostate cancers

  • Further development in this field might create new opportunities in breast and prostate cancer treatments

  • Includes supplementary material: sn.pub/extras

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Non-genomic Action of Steroid Hormones: More Questions than Answers

    • Antimo Migliaccio, Gabriella Castoria, Antonio Bilancio, Pia Giovannelli, Marzia Di Donato, Ferdinando Auricchio
    Pages 1-15

  3. Breast Cancer

    1. Front Matter

      Pages 17-17
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  4. Breast cancer

    1. Progesterone Signaling to Chromatin in Breast Cancer Cells. Two Initial Cycles of Remodeling

      • Guillermo P. Vicent, Roser Zaurin, Cecilia Ballaré, A. Silvina Nacht, Roni H. G. Wright, Francois Le Dily et al.
      Pages 19-29

    2. Cooperative Interactions Between c-Src, Estrogen Receptors and Receptor Tyrosine Kinases in Breast Cancer

      • Sarah J. Parsons, Jessica E. Pritchard, Emily M. Fox, Margaret A. Shupnik
      Pages 31-59

    3. Cross Talk Between ERα and Src Signaling and Its Relevance to ER Status and Hormone Responsiveness

      • Jun Sun, Wen Zhou, Zafar Nawaz, Joyce M. Slingerland
      Pages 61-78

    4. Post-translational Modifications of ER Alpha in Rapid Estrogen’s Action

      • Muriel Le Romancer, Coralie Poulard, Stéphanie Sentis, Laura Corbo
      Pages 79-93

    5. Sex-Steroid Rapid Action and Its Role in Invasiveness and Metastasis of Breast Cancer

      • Marina Ines Flamini, Angel Matias Sanchez, Xiao-Dong Fu, Tommaso Simoncini
      Pages 95-114

    6. Unraveling the Role of GPER in Breast Cancer

      • Rosamaria Lappano, Marcello Maggiolini
      Pages 115-127

    7. Nongenomic Actions of Estrogens and Xenoestrogens Affecting Endocrine Cancer Cells

      • Cheryl S. Watson, Dragoslava Zivadinovic, Yow-Jiun Jeng, Rebecca A. Alyea, Terumi Midoro-Horiuti, Randall Goldblum et al.
      Pages 129-142

  5. Prostate Cancer

    1. Front Matter

      Pages 143-143
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  6. Prostate cancer

    1. Differential Functions of Stromal and Epithelial Androgen Receptor in Prostate Cancer Before and After Castration Resistant Stage

      • S. Lee, K.- P. Lai, S. Yeh, C. Chang
      Pages 145-163

    2. Role of Androgens and Androgen Receptor in Prostate Cancer: Genomic and Non-Genomic Actions

      • Sara Marchiani, Lara Tamburrino, Monica Muratori, Lorella Bonaccorsi, Gianni Forti, Elisabetta Baldi
      Pages 165-177

    3. Mechanisms of Signal Transduction in Prostate Cancer: The Role of PI3-Kinase Pathway in Androgen Action

      • Laurent Morel, Silvère Baron
      Pages 179-192

    4. The IGF-I Axis in Prostate Cancer: The Role of Rapid Steroid Actions

      • Antonino Belfiore
      Pages 193-212

    5. Androgen Receptor Pathway in Prostate Cancer: Old Target and New Drugs

      • Christophe Massard, Karim Fizazi
      Pages 213-223

  7. New Tools for Steroid Receptor Analysis and Regulatory Networks

    1. Front Matter

      Pages 225-225
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  8. New tools for steroid receptor analysis and regulatory networks

    1. Quantitative Visualization of Sex Steroid Receptor Functions: AR and ERα

      • Michael J. Bolt, Sean M. Hartig, Adam T. Szafran, Sanjay N. Mediwala, Marco Marcelli, Michael A. Mancini
      Pages 227-252

    2. Micropatterned Surfaces as Tools for the Study of the Rapid Non-Genomic Actions of Steroid Receptors

      • Andrew C. B. Cato, Emmanuel Oppong, Sylwia Sekula-Neuner
      Pages 253-266

  9. Back Matter

    Pages 267-268
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About this book

Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.

Editors and Affiliations

  • University of Naples, Naples, Italy

    Gabriella Castoria

  • Department of Pathology, II University of Naples, Naples, Italy

    Antimo Migliaccio

Bibliographic Information

  • Book Title: Advances in Rapid Sex-Steroid Action

  • Book Subtitle: New Challenges and New Chances in Breast and Prostate Cancers

  • Editors: Gabriella Castoria, Antimo Migliaccio

  • DOI: https://doi.org/10.1007/978-1-4614-1764-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4614-1763-7Published: 14 December 2011

  • Softcover ISBN: 978-1-4899-8935-2Published: 03 March 2014

  • eBook ISBN: 978-1-4614-1764-4Published: 15 December 2011

  • Edition Number: 1

  • Number of Pages: XVIII, 270

  • Topics: Cancer Research, Endocrinology, Biomedicine general

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