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The Neuropharmacology of Impulsive Behaviour, an Update

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Recent Advances in Research on Impulsivity and Impulsive Behaviors

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 47))

Abstract

Neuropharmacological interventions in preclinical translational models of impulsivity have tremendously contributed to a better understanding of the neurochemistry and neural basis of impulsive behaviour. In this regard, much progress has been made over the last years, also due to the introduction of novel techniques in behavioural neuroscience such as optogenetics and chemogenetics. In this chapter, we will provide an update of how the behavioural pharmacology field has progressed and built upon existing data since an earlier review we wrote in 2008. To this aim, we will first give a brief background on preclinical translational models of impulsivity. Next, recent interesting evidence of monoaminergic modulation of impulsivity will be highlighted with a focus on the neurotransmitters dopamine and noradrenaline. Finally, we will close the chapter by discussing some novel directions and drug leads in the neuropharmacological modulation of impulsivity.

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Authors and Affiliations

  1. Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, The Netherlands

    Tommy Pattij

  2. Division of Behavioural Neuroscience, Department of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

    Louk J. M. J. Vanderschuren

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  1. Tommy Pattij
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  2. Louk J. M. J. Vanderschuren
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Correspondence to Tommy Pattij .

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Editors and Affiliations

  1. Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA

    Harriet de Wit

  2. Department of Psychology, Binghamton University, State University of New York, Binghamton, NY, USA

    J. David Jentsch

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Pattij, T., Vanderschuren, L.J.M.J. (2020). The Neuropharmacology of Impulsive Behaviour, an Update. In: de Wit, H., Jentsch, J.D. (eds) Recent Advances in Research on Impulsivity and Impulsive Behaviors. Current Topics in Behavioral Neurosciences, vol 47. Springer, Cham. https://doi.org/10.1007/7854_2020_143

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