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Assessment of Taste Function

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The Pharmacology of Taste

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 275))

Abstract

Taste disorders, impacting well-being and physical health, can be caused by many etiologies including the use of medication. Recently, taste disturbance is also considered as one of the predominant symptoms of COVID-19 although its pathogenesis requires further research. Localized taste disorders may be overlooked considering that whole-mouth taste perception is insured through several mechanisms. Individuals often fail to discern taste from flavor, and interviews/surveys are insufficient to properly assess taste function. Hence, various taste assessment methods have been developed. Among them, psychophysical methods are most widely applied in a clinical context. Less-biased electrophysiological, imaging, or morphological methods are used to a much lesser degree. Overall, more research is needed in the field of taste.

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References

  • Abarintos RA, Jimenez JC, Tucker RM, Smutzer G (2019) Development of a regional taste test that uses edible circles for stimulus delivery. Chemosens Percept 12:115–124

    Article  PubMed  PubMed Central  Google Scholar 

  • Ackerman BH, Kasbekar N (1997) Disturbances of taste and smell induced by drugs. Pharmacotherapy 17:482–496

    Article  CAS  PubMed  Google Scholar 

  • Ahne G, Erras A, Hummel T, Kobal G (2000) Assessment of gustatory function by means of tasting tablets. Laryngoscope 110:1396–1401

    Article  CAS  PubMed  Google Scholar 

  • Archer NS, Liu D, Shaw J, Hannan G, Duesing K, Keast R (2016) A comparison of collection techniques for gene expression analysis of human Oral taste tissue. PLoS One 11:e0152157

    Article  PubMed  PubMed Central  Google Scholar 

  • Archer N, Shaw J, Cochet-Broch M, Bunch R, Poelman A, Barendse W, Duesing K (2019) Obesity is associated with altered gene expression in human tastebuds. Int J Obes 43:1475–1484

    Article  Google Scholar 

  • Arias C, Chotro MG (2005) Increased preference for ethanol in the infant rat after prenatal ethanol exposure, expressed on intake and taste reactivity tests. Alcohol Clin Exp Res 29:337–346

    Article  PubMed  Google Scholar 

  • Astbäck J, Fernström A, Hylander B, Arvidson K, Johansson O (1999) Taste buds and neuronal markers in patients with chronic renal failure. Perit Dial Int 19(Suppl 2):S315–S323

    Article  PubMed  Google Scholar 

  • Atkin-Thor E, Goddard BW, O’Nion J, Stephen RL, Kolff W (1978) Hypogeusia and zinc depletion in chronic dialysis patients. Am J Clin Nutr 31:1948–1951

    Article  CAS  PubMed  Google Scholar 

  • Bagla R, Klasky B, Doty RL (1997) Influence of stimulus duration on a regional measure of NaCl taste sensitivity. Chem Senses 22:171–175

    Article  CAS  PubMed  Google Scholar 

  • Baker AN, Bakke AJ, Branstetter SA, Hayes JE (2020) Harsh and sweet sensations predict acute liking of electronic cigarettes, but flavor does not affect acute nicotine intake: a pilot laboratory study in men. Nicotine Tob Res 23(4):687–693

    Article  Google Scholar 

  • Barragán R, Coltell O, Portolés O, Asensio EM, Sorlí JV, Ortega-Azorín C, González JI, Sáiz C, Fernández-Carrión R, Ordovas JM, Corella D (2018) Bitter, sweet, salty, sour and umami taste perception decreases with age: sex-specific analysis, modulation by genetic variants and taste-preference associations in 18 to 80 year-old subjects. Nutrients 10:1539

    Article  PubMed Central  Google Scholar 

  • Bartoshuk LM (1989) Taste: robust across the age span? Ann N Y Acad Sci 561:65–75

    Article  CAS  PubMed  Google Scholar 

  • Bartoshuk LM, Gent J, Catalanotto FA, Goodspeed RB (1983) Clinical evaluation of taste. Am J Otolaryngol 4:257

    Article  CAS  PubMed  Google Scholar 

  • Bartoshuk LM, Rifkin B, Marks LE, Bars P (1986) Taste and aging. J Gerontol 41:51–57

    Article  CAS  PubMed  Google Scholar 

  • Bartoshuk LM, Duffy VB, Green BG, Hoffman HJ, Ko CW, Lucchina LA, Marks LE, Snyder DJ, Weiffenbach JM (2004) Valid across-group comparisons with labeled scales: the gLMS versus magnitude matching. Physiol Behav 82:109–114

    Article  CAS  PubMed  Google Scholar 

  • Beckstead RM, Morse JR, Norgren R (1980) The nucleus of the solitary tract in the monkey: projections to the thalamus and brain stem nuclei. J Comp Neurol 190:259–282

    Article  CAS  PubMed  Google Scholar 

  • Bergdahl M, Bergdahl J (2002) Perceived taste disturbance in adults: prevalence and association with oral and psychological factors and medication. Clin Oral Investig 6:145–149

    Article  PubMed  Google Scholar 

  • Berling K, Knutsson J, Rosenblad A, von Unge M (2011) Evaluation of electrogustometry and the filter paper disc method for taste assessment. Acta Otolaryngol 131:488–493

    Article  PubMed  Google Scholar 

  • Berry DN, Simons CT (2020) Assessing regional sensitivity and desensitization to capsaicin among oral cavity mucosae. Chem Senses 45:bjaa033

    Article  Google Scholar 

  • Berteretche MV, Dalix AM, d’Ornano AM, Bellisle F, Khayat D, Faurion A (2004) Decreased taste sensitivity in cancer patients under chemotherapy. Support Care Cancer 12:571–576

    Article  CAS  PubMed  Google Scholar 

  • Bice PJ, Kiefer SW (1990) Taste reactivity in alcohol preferring and nonpreferring rats. Alcohol Clin Exp Res 14:721–727

    Article  CAS  PubMed  Google Scholar 

  • Bishop PA, Herron RL (2015) Use and misuse of the likert item responses and other ordinal measures. Int J Exerc Sci 8:297–302

    PubMed  PubMed Central  Google Scholar 

  • Bitter T, Laetzel M, Lehnich H, Guntinas-Lichius O, Gudziol H (2010) Suprathreshold gustatory stimuli cause biphasic respiratory responses during resting respiration in humans. Laryngoscope 120:849–853

    Article  PubMed  Google Scholar 

  • Bong JL, Lucke TW, Evans CD (1998) Persistent impairment of taste resulting from terbinafine. Br J Dermatol 139:747–748

    Article  CAS  PubMed  Google Scholar 

  • Boucher Y, Simons CT, Faurion A, Azerad J, Carstens E (2003) Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract. Brain Res 973:265–274

    Article  CAS  PubMed  Google Scholar 

  • Bromley SM, Doty RL (2019) Health histories and medical evaluations of patients with complaints of chemosensory dysfunction. Handb Clin Neurol 164:219–227

    Article  PubMed  Google Scholar 

  • Burch RE, Sackin DA, Ursick JA, Jetton MM, Sullivan JF (1978) Decreased taste and smell acuity in cirrhosis. Arch Intern Med 138:743–746

    Article  CAS  PubMed  Google Scholar 

  • Burlingame GA, Dietrich AM, Whelton AJ (2007) Understanding the basics of tap water taste. J Am Water Works Ass 99:100–111

    Article  CAS  Google Scholar 

  • Cai H, Cong WN, Daimon CM, Wang R, Tschöp MH, Sévigny J, Martin B, Maudsley S (2013) Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. PLoS One 8:e76553

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, Brown RG, Koller W, Barone P, MacPhee G, Kelly L, Rabey M, MacMahon D, Thomas S, Ondo W, Rye D, Forbes A, Tluk S, Dhawan V, Bowron A, Williams AJ, Olanow CW (2006) International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord 21:916–923

    Article  PubMed  Google Scholar 

  • Cheled-Shoval SL, Reicher N, Niv MY, Uni Z (2017) Detecting thresholds for bitter, umami, and sweet tastants in broiler chicken using a 2-choice test method. Poult Sci 96:2206–2218

    Article  CAS  PubMed  Google Scholar 

  • Clark JE (1998) Taste and flavour: their importance in food choice and acceptance. Proc Nutr Soc 57:639–643

    Article  CAS  PubMed  Google Scholar 

  • Cometto-Muñiz JE, Cain WS, Abraham MH, Kumarsingh R (1998) Sensory properties of selected terpenes. Thresholds for odor, nasal pungency, nasal localization, and eye irritation. Ann N Y Acad Sci 855:648–651

    Article  PubMed  Google Scholar 

  • Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, Weinreb C, Joseph PV, Larson ED, Parma V (2020) COVID-19 and the chemical senses: supporting players take center stage. Neuron 107(2):219–233

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Correia C, Lopez KJ, Wroblewski KE, Huisingh-Scheetz M, Kern DW, Chen RC, Schumm LP, Dale W, McClintock MK, Pinto JM (2016) Global sensory impairment in older adults in the United States. J Am Geriatr Soc 64:306–313

    Article  PubMed  PubMed Central  Google Scholar 

  • de Araujo IE, Kringelbach ML, Rolls ET, McGlone F (2003) Human cortical responses to water in the mouth, and the effects of thirst. J Neurophysiol 90:1865–1876

    Article  PubMed  Google Scholar 

  • Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, Kimmelman CP, Brightman VJ, Snow JB (1991) Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 117:519–528

    Article  CAS  PubMed  Google Scholar 

  • Delwiche JF, Buletic Z, Breslin PA (2001) Covariation in individuals’ sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms. Percept Psychophys 63:761–776

    Article  CAS  PubMed  Google Scholar 

  • Deshpande TS, Blanchard P, Wang L, Foote RL, Zhang X, Frank SJ (2018) Radiation-related alterations of taste function in patients with head and neck cancer: a systematic review. Curr Treat Options in Oncol 19:72

    Article  Google Scholar 

  • Dotson CD, Spector AC (2007) Behavioral discrimination between sucrose and other natural sweeteners in mice: implications for the neural coding of T1R ligands. J Neurosci 27:11242–11253

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Doty RL (2018a) Age-related deficits in taste and smell. Otolaryngol Clin N Am 51:815–825

    Article  Google Scholar 

  • Doty RL (2018b) Measurement of chemosensory function. World J Otorhinolaryngol Head Neck Surg 4:11–28

    Article  PubMed  PubMed Central  Google Scholar 

  • Doty RL, Bromley SM (2004) Effects of drugs on olfaction and taste. Otolaryngol Clin N Am 37:1229–1254

    Article  Google Scholar 

  • Doty RL, Haxel BR (2005) Objective assessment of terbinafine-induced taste loss. Laryngoscope 115:2035–2037

    Article  CAS  PubMed  Google Scholar 

  • Doty RL, Bagla R, Morgenson M, Mirza N (2001) NaCl thresholds: relationship to anterior tongue locus, area of stimulation, and number of fungiform papillae. Physiol Behav 72:373–378

    Article  CAS  PubMed  Google Scholar 

  • Doty RL, Shah M, Bromley SM (2008) Drug-induced taste disorders. Drug Saf 31:199–215

    Article  CAS  PubMed  Google Scholar 

  • Doty RL, Nsoesie MT, Chung I, Osman A, Pawasarat I, Caulfield J, Hurtig H, Silas J, Dubroff J, Duda JE, Ying GS, Tekeli H, Leon-Sarmiento FE (2015) Taste function in early stage treated and untreated Parkinson’s disease. J Neurol 262:547–557

    Article  CAS  PubMed  Google Scholar 

  • Doty RL, Heidt JM, MacGillivray MR, Dsouza M, Tracey EH, Mirza N, Bigelow D (2016) Influences of age, tongue region, and chorda tympani nerve sectioning on signal detection measures of lingual taste sensitivity. Physiol Behav 155:202–207

    Article  CAS  PubMed  Google Scholar 

  • Ehrenstein WH, Ehrenstein A (1999) Psychophysical methods. In: Windhorst U, Johansson H (eds) Modern techniques in neuroscience research. Springer, Berlin, pp 1211–1241

    Chapter  Google Scholar 

  • Ellegard EK, Goldsmith D, Hay KD, Morton RP (2007) Studies on the relationship between electrogustometry and sour taste perception. Auris Nasus Larynx 334:477–480

    Article  Google Scholar 

  • Epstein JB, Villines D, Epstein GL, Smutzer G (2020) Oral examination findings, taste and smell testing during and following head and neck cancer therapy. Support Care Cancer 28:4305–4311

    Article  PubMed  Google Scholar 

  • Eylam S, Spector AC (2004) Stimulus processing of glycine is dissociable from that of sucrose and glucose based on behaviorally measured taste signal detection in Sac ‘taster’ and ‘non-taster’ mice. Chem Senses 29:639–649

    Article  CAS  PubMed  Google Scholar 

  • Fark T, Hummel C, Hähner A, Nin T, Hummel T (2013) Characteristics of taste disorders. Eur Arch Otorhinolaryngol 270:1855–1860

    Article  CAS  PubMed  Google Scholar 

  • Fischer ME, Cruickshanks KJ, Schubert CR, Pinto A, Klein R, Pankratz N, Pankow JS, Huang GH (2013) Factors related to fungiform papillae density: the beaver dam offspring study. Chem Senses 38:669–677

    Article  PubMed  PubMed Central  Google Scholar 

  • Fons M, Osterhammel A (1966) Electrogustometry. Arch Otolaryngol 83:538

    Article  CAS  PubMed  Google Scholar 

  • Frank ME, Smith DV (1991) Electrogustometry: a simple way to test taste. In: Getchell TV, Doty RL, Bartoshuk LM, Snow JBJ (eds) Smell and taste in health and disease. Raven Press, New York, pp 503–514

    Google Scholar 

  • Fujii M, Fukazawa K, Hashimoto Y, Takayasu S, Umemoto M, Negoro A, Sakagami M (2004) Clinical study of flavor disturbance. Acta Otolaryngol 164:109–112

    Article  Google Scholar 

  • Fukunaga A, Uematsu H, Sugimoto K (2005) Influences of aging on taste perception and oral somatic sensation. J Gerontol A Biol Sci Med Sci 60:109–113

    Article  PubMed  Google Scholar 

  • Gaillard D, Stratford JM (2016) Measurement of behavioral taste responses in mice: two-bottle preference, lickometer, and conditioned taste-aversion tests. Curr Protoc Mouse Biol 6:380–407

    Article  PubMed  PubMed Central  Google Scholar 

  • Genow A, Hummel T, Kroger H, Bagla R, Bigelow DC (1998) Gustatory event-related potentials in healthy controls and patients with hypogeusia or ageusia. Chem Senses 23:606–607

    Google Scholar 

  • Glendinning JI, Stano S, Holter M, Azenkot T, Goldman O, Margolskee RF, Vasselli JR, Sclafani A (2015) Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice. Am J Physiol Regul Integr Comp Physiol 309:R552–R560

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grungreiff K, Abicht K, Kluge M, Presser HJ, Franke D, Kleine FD, xx, x. (1988) Clinical studies on zinc in chronic liver diseases. Z Gastroenterol 26:409–415

    CAS  PubMed  Google Scholar 

  • Grzegorczyk PB, Jones SW, Mistretta CM (1979) Age-related differences in salt taste acuity. J Gerontol 34:834

    Article  CAS  PubMed  Google Scholar 

  • Guder E, Böttcher A, Pau HW, Just T (2012) Taste function after stapes surgery. Auris Nasus Larynx 39:562–566

    Article  PubMed  Google Scholar 

  • Gudziol H, Hummel T (2007) Normative values for the assessment of gustatory function using liquid tastants. Acta Otolaryngol 127:658–661

    Article  CAS  PubMed  Google Scholar 

  • Gudziol H, Rahneberg K, Burkert S (2007) Anosmics are more poorly able to taste than normal persons. Laryngorhinootologie 86:640–643

    Article  CAS  PubMed  Google Scholar 

  • Gudziol H, Laetzel M, Lehnich H, Bitter T (2010) Gustatory input affects breathing pattern: a method for objectifying of gustatory perception. Laryngorhinootologie 89:78–83

    Article  CAS  PubMed  Google Scholar 

  • Hahn H, Günther H (1933) Über die Reize und die Reizbedingungen des Geschmackssinnes. Pflügers Arch Ges Physiol 231:48

    Article  Google Scholar 

  • Hald M, Hald MO, Stankovic J, Niklassen AS, Ovesen T (2021) Positive association between bitter taste threshold and preference of vegetables among adolescents. Acta Paediatr 110:875–880

    Article  PubMed  Google Scholar 

  • Han P, Georgi M, Cuevas M, Haehner A, Gudziol V, Hummel T (2018) Decreased electrogustometric taste sensitivity in patients with acquired olfactory dysfunction. Rhinology 56:158–165

    Article  CAS  PubMed  Google Scholar 

  • Harris H, Kalmus H (1949) The measurement of taste sensivity to phenylthiourea (P.T.C). Ann Eugenics 15:24

    Article  CAS  Google Scholar 

  • Heft MW, Robinson ME (2014) Age differences in suprathreshold sensory function. Age 36:1–8

    Article  PubMed  Google Scholar 

  • Henkin RI, Larson AL (1972) On the mechanism of hyposmia following laryngectomy in man. Laryngoscope 82:836–843

    Article  CAS  PubMed  Google Scholar 

  • Henkin RI, Gill JR, Bartter FC (1963) Studies on taste thresholds in normal man and in patients with adrenal cortical insufficiency: the role of acrenal cortical steroids and serum sodium concentration. J Clin Invest 42:727–735

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Henkin R, Larson A, Powell R (1975) Hypogeusia, dysgeusia, hyposmia, and dysosmia following influenza-like infection. Ann Otol Rhinol Laryngol 84:672–682

    Article  CAS  PubMed  Google Scholar 

  • Hintschich CA, Wenzel JJ, Hummel T, Hankir MK, Kühnel T, Vielsmeier V, Bohr C (2020) Psychophysical tests reveal impaired olfaction but preserved gustation in COVID-19 patients. Int Forum Allergy Rhinol 10(9):1105–1107

    Article  PubMed  Google Scholar 

  • Höchenberger R, Ohla K (2017) Rapid estimation of gustatory sensitivity thresholds with SIAM and QUEST. Front Psychol 8:981

    Article  PubMed  PubMed Central  Google Scholar 

  • Höchenberger R, Ohla K (2019) Repeatability of taste recognition threshold measurements with QUEST and Quick Yes-No. Nutrients 12:24

    Article  PubMed Central  Google Scholar 

  • Hoehl K, Schoenberger GU, Busch-Stockfisch M (2010) Water quality and taste sensitivity for basic tastes and metallic sensation. Food Qual Prefer 21:243–249

    Article  Google Scholar 

  • Hong JH, Chung JW, Kim YK, Chung SC, Lee SW, Kho HS (2005) The relationship between PTC taster status and taste thresholds in young adults. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:711–715

    Article  PubMed  Google Scholar 

  • Huart C, Philpott C, Konstantinidis I, Altundag A, Whitcroft KL, Trecca EMC, Cassano M, Rombaux P, Hummel T (2020) Comparison of COVID-19 and common cold chemosensory dysfunction. Rhinology 58:623–625

    Article  CAS  PubMed  Google Scholar 

  • Hummel T, Erras A, Kobal G (1997) A new test for the screening of taste function. Rhinology 35:146–148

    CAS  PubMed  Google Scholar 

  • Hummel C, Frasnelli J, Gerber J, Hummel T (2007) Cerebral processing of gustatory stimuli in patients with taste loss. Behav Brain Res 185:59–64

    Article  CAS  PubMed  Google Scholar 

  • Hummel T, Genow A, Landis BN (2010) Clinical assessment of human gustatory function using event related potentials. J Neurol Neurosurg Psychiatry 81:459–464

    Article  PubMed  Google Scholar 

  • Hummel T, Hummel C, Welge-Luessen A (2013) Assessment of olfaction and gustation. In: Welge-Luessen A, Hummel T (eds) Management of smell and taste disorders: a practical guide for clinicians. Thieme, Stuttgart, pp 58–75

    Google Scholar 

  • Hur K, Choi JS, Zheng M, Shen J, Wrobel B (2018) Association of alterations in smell and taste with depression in older adults. Laryngoscope Investig Otolaryngol 3:94–99

    Article  PubMed  PubMed Central  Google Scholar 

  • Ikeda K (1909) On a new seasoning. J Tokyo Chem Soc 30:820–836

    Google Scholar 

  • Ikeda K (2002) New seasonings. Chem Senses 27:847–849

    Article  PubMed  Google Scholar 

  • Ikeda M, Aiba T, Ikui A, Inokuchi A, Kurono Y, Sakagami M, Takeda N, Tomita H (2005) Taste disorders: a survey of the examination methods and treatments used in Japan. Acta Otolaryngol 125:1203–1210

    Article  PubMed  Google Scholar 

  • Ikeda M, Ikui A, Komiyama A, Kobayashi D, Tanaka M (2008) Causative factors of taste disorders in the elderly, and therapeutic effects of zinc. J Laryngologyot 122:155

    Article  CAS  Google Scholar 

  • Itoh I, Ikui A, Ikeda M, Tomita H, Souhei E (2002) Taste disorder involving Hunter’s glossitis following total gastrectomy. Acta Otolaryngol 122:159–163

    Article  Google Scholar 

  • Just T, Hummel T (2010) In reference to capsaicin receptors are colocalized with sweet/bitter receptors in the taste sensing cells of circumvallate papillae. Genes Nutr 5:181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Just T, Pau HW, Witt M, Hummel T (2006) Contact endoscopic comparison of morphology of human fungiform papillae of healthy subjects and patients with transected chorda tympani nerve. Laryngoscope 116:1216–1222

    Article  PubMed  Google Scholar 

  • Just T, Pau HW, Steiner S, Hummel T (2007) Assessment of oral trigeminal sensitivity in humans. Eur Arch Otorhinolaryngol 264:545–551

    Article  PubMed  Google Scholar 

  • Just T, Srur E, Stachs O, Pau HW (2009) Volumetry of human taste buds using laser scanning microscopy. J Laryngol Otol 123:1125–1130

    Article  CAS  PubMed  Google Scholar 

  • Kinnamon SC, Finger TE (2019) Recent advances in taste transduction and signaling. F1000Research 8:32185015

    Article  Google Scholar 

  • Kobal G (1985) Gustatory evoked potentials in man. Electroencephalogr Clin Neurophysiol 62:449–454

    Article  CAS  PubMed  Google Scholar 

  • Koh SD, Teitelbaum P (1961) Absolute behavioral taste thresholds in the rat. J Comp Physiol Psychol 54:223–229

    Article  CAS  PubMed  Google Scholar 

  • Konstantinidis I, Chatziavramidis A, Printza A, Metaxas S, Constantinidis J (2010) Effects of smoking on taste: assessment with contact endoscopy and taste strips. Laryngoscope 120:1958–1963

    Article  PubMed  Google Scholar 

  • Krarup B (1958) Electrogustometry: a method for clinical “taste examinations”. Acta Otolaryngol 49:294

    Article  CAS  PubMed  Google Scholar 

  • Landis BN, Guinand NO (2009) Selective taste disorder after temporal bone fracture. J Clin Neurosci 16:605

    Article  PubMed  Google Scholar 

  • Landis BN, Heckmann JG (2013) Taste disorders. In: Welge-Lüssen A, Hummel T (eds) Management of smell and taste disorders – a practical guide for clinicians. Thieme Verlag, Stuttgart, pp 179–188

    Google Scholar 

  • Landis BN, Welge-Luessen A, Brämerson A, Bende M, Mueller CA, Nordin S, Hummel T (2008) Normative values for the assessment of gustatory function using impregnated filter papers (“Taste Strips”). Arch ORL 256:242–248

    Google Scholar 

  • Landis BN, Welge-Luessen A, Brämerson A, Bende M, Mueller CA, Nordin S, Hummel T (2009) “Taste Strips” – a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol 256:242–248

    Article  PubMed  Google Scholar 

  • Landis BN, Scheibe M, Weber C, Berger R, Bramerson A, Bende M, Nordin S, Hummel T (2010) Chemosensory interaction: acquired olfactory impairment is associated with decreased taste function. J Neurol 257:1303–1308

    Article  PubMed  Google Scholar 

  • Lang C, Leuschner T, Ulrich K, Stössel C, Heckmann J, Hummel T (2006) Taste in dementing diseases and parkinsonism. J Neurol Sci 248:177–184

    Article  CAS  PubMed  Google Scholar 

  • Le Floch JP, Le Lièvre G, Labroue M, Peynègre R, Perlemuter L (1992) Early detection of diabetic patients at risk of developing degenerative complications using electric gustometry: a five-year follow-up study. Eur J Med 1:208–214

    PubMed  Google Scholar 

  • Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (2002) Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 99:4692–4696

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lindley C, McCune JS, Thomason TE, Lauder D, Sauls A, Adkins S, Sawyer WT (1999) Perception of chemotherapy side effects cancer versus noncancer patients. Cancer Pract 7:59–65

    Article  CAS  PubMed  Google Scholar 

  • Linschoten MR, Harvey LO Jr, Eller PM, Jafek BW (2001) Fast and accurate measurement of taste and smell thresholds using a maximum-likelihood adaptive staircase procedure. Percept Psychophys 63:1330–1347

    Article  CAS  PubMed  Google Scholar 

  • Mäkelä MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimäki M, Blomqvist S, Hyypiä T, Arstila P (1998) Viruses and bacteria in the etiology of the common cold. J Clin Microbiol 36:539–542

    Article  PubMed  PubMed Central  Google Scholar 

  • Manzi B, Hummel T (2014) Intensity of regionally applied tastes in relation to administration method: an investigation based on the “taste strips” test. Eur Arch Otorhinolaryngol 271:411–415

    Article  PubMed  Google Scholar 

  • Marinella MA (2008) Paraneoplastic salt dysgeusia. South Med J 101:1275

    Article  PubMed  Google Scholar 

  • McMahon DB, Shikata H, Breslin PA (2001) Are human taste thresholds similar on the right and left sides of the tongue? Chem Senses 26:875–883

    Article  CAS  PubMed  Google Scholar 

  • Melis M, Sollai G, Mastinu M, Pani D, Cosseddu P, Bonfiglio A, Crnjar R, Tepper BJ, Barbarossa IT (2020) Electrophysiological responses from the human tongue to the six taste qualities and their relationships with PROP taster status. Nutrients 12:2017

    Article  CAS  PubMed Central  Google Scholar 

  • Melis M, Haehner A, Mastinu M, Hummel T, Tomassini Barbarossa I (2021) Molecular and genetic factors involved in olfactory and gusta-tory deficits and associations with microbiota in Parkinson’s Diseas. Int J Mol Sci 22:4286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mestre ZL, Bischoff-Grethe A, Eichen DM, Wierenga CE, Strong D, Boutelle KN (2017) Hippocampal atrophy and altered brain responses to pleasant tastes among obese compared with healthy weight children. Int J Obes 41:1496–1502

    Article  CAS  Google Scholar 

  • Migneault-Bouchard C, Hsieh JW, Hugentobler M, Frasnelli J, Landis BN (2020) Chemosensory decrease in different forms of olfactory dysfunction. J Neurol 267:138–143

    Article  CAS  PubMed  Google Scholar 

  • Miles BL, Van Simaeys K, Whitecotton M, Simons CT (2018) Comparative tactile sensitivity of the fingertip and apical tongue using complex and pure tactile tasks. Physiol Behav 194:515–521

    Article  CAS  PubMed  Google Scholar 

  • Miller SL, Mirza N, Doty RL (2002) Electrogustometric thresholds: relationship to anterior tongue locus, area of stimulation, and number of fungiform papillae. Penn Dent J 102(6–7):31–32

    Google Scholar 

  • Monteleone AM, Monteleone P, Esposito F, Prinster A, Volpe U, Cantone E, Pellegrino F, Canna A, Milano W, Aiello M, Di Salle F, Maj M (2017) Altered processing of rewarding and aversive basic taste stimuli in symptomatic women with anorexia nervosa and bulimia nervosa: an fMRI study. J Psychiatr Res 90:94–101

    Article  PubMed  Google Scholar 

  • Morita Y, Finger TE (1985) Reflex connections of the facial and vagal gustatory systems in the brainstem of the bullhead catfish, Ictalurus nebulosus. J Comp Neurol 231:547–558

    Article  CAS  PubMed  Google Scholar 

  • Mueller C, Kallert S, Renner B, Stiassny K, Temmel AF, Hummel T, Kobal G (2003) Quantitative assessment of gustatory function in a clinical context using impregnated “taste strips”. Rhinology 41:2–6

    CAS  PubMed  Google Scholar 

  • Mueller CA, Pintscher K, Renner B (2011) Clinical test of gustatory function including umami taste. Ann Otol Rhinol Laryngol 120:358–362

    Article  PubMed  Google Scholar 

  • Mukherjee N, Delay ER (2011) Cyclophosphamide-induced disruption of umami taste functions and taste epithelium. Neuroscience 192:732–745

    Article  CAS  PubMed  Google Scholar 

  • Murphy C, Quinonez C, Nordin S (1995) Reliability and validity of electrogustometry and its application to young and elderly persons. Chem Senses 10:499–503

    Article  Google Scholar 

  • Nagai A, Kubota M, Kubota M, Katayama Y, Kojima C (2012) Evaluation of taste acuity by the filter-paper disc in Japanese young women: the relationship with micronutrients status. Asia Pac J Clin Nutr 21:406–410

    PubMed  Google Scholar 

  • Nakajima M, Ohtsuki T, Minematsu K (2010) Bilateral hypogeusia in a patient with a unilateral paramedian thalamic infarction. J Neurol Neurosurg Psychiatry 81:700–701

    Article  PubMed  Google Scholar 

  • Nakazato M, Endo S, Yoshimura I, Tomita H (2002) Influence of aging on electrogustometry thresholds. Acta Otolaryngol 546(Suppl):16–26

    Article  Google Scholar 

  • Nasser J (2001) Taste, food intake and obesity. Obes Rev 2:213–218

    Article  CAS  PubMed  Google Scholar 

  • Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS (2002) An amino-acid taste receptor. Nature 416:199–202

    Article  CAS  PubMed  Google Scholar 

  • Neumann CE (1864) Die Electricität als Mittel zur Untersuchung des Geschmacksinnes im gesunden und kranken Zustände und die Geschmacksfunction der Chorda tympani. Königsb Med Jahrb 4:1–22

    Google Scholar 

  • Nicolaescu SA, Wertheimer JM, Barbash SE, Doty RL (2005) Electrical taste thresholds established on the medial tongue using two sizes of electrodes. Laryngoscope 115:1509–1511

    Article  PubMed  Google Scholar 

  • Ninomiya Y, Funakoshi M (1989) Behavioral discrimination between glutamate and the four basic taste substances in mice. Comp Biochem Physiol A Comp Physiol 92:365–370

    Article  CAS  PubMed  Google Scholar 

  • Nordin S, Bramerson A, Bringlov E, Kobal G, Hummel T, Bende M (2007) Substance and tongue-region specific loss in basic taste-quality identification in elderly adults. Eur Arch Otorhinolaryngol 264:285–289

    Article  PubMed  Google Scholar 

  • Nuessle TM, Garneau NL, Sloan MM, Santorico SA (2015) Denver papillae protocol for objective analysis of fungiform papillae. J Vis Exp 100:e52860

    Google Scholar 

  • O’Mahony M (1983) Gustatory responses to nongustatory stimuli. Perception 12:627

    Article  PubMed  Google Scholar 

  • O’Mahony M (1995) Who told you the triangle test was simple? Food Qual Prefer 6:227–238

    Article  Google Scholar 

  • O’Mahony M, Ivory H, King E (1974) Pair comparison and ascending series NaCl threshold: criterion and residual effects. Perception 3:185–192

    Article  PubMed  Google Scholar 

  • Ostrom K, Catalanotto F, Gent J, Bartoshuk L (1985) Effects of oral sensory field loss on taste scaling ability, Chemical senses, vol 10. Oxford Univ Press, Oxford, p 459

    Google Scholar 

  • Ozdener H, Spielman AI, Rawson NE (2012) Isolation and culture of human fungiform taste papillae cells. J Vis Exp 63:e3730

    Google Scholar 

  • Pavlidis P, Gouveris H, Anogeianaki A, Koutsonikolas D, Anogianakis G, Kekes G (2013) Age-related changes in electrogustometry thresholds, tongue tip vascularization, density, and form of the fungiform papillae in humans. Chem Senses 38:35–43

    Article  CAS  PubMed  Google Scholar 

  • Pavlidis P, Gouveris C, Kekes G, Maurer J (2014a) Changes in electrogustometry thresholds, tongue tip vascularization, density and form of the fungiform papillae in smokers. Eur Arch Otorhinolaryngol 271:2325–2331

    Article  PubMed  Google Scholar 

  • Pavlidis P, Gouveris H, Kekes G, Maurer J (2014b) Electrogustometry thresholds, tongue tip vascularization, and density and morphology of the fungiform papillae in diabetes. B-ENT 10:271–278

    CAS  PubMed  Google Scholar 

  • Pavlidis P, Gouveris H, Gorgulla H, Hast HJ, Maurer J (2015) Electrogustometry and contact endoscopy findings in patients with head and neck malignancies treated with chemotherapy, radiotherapy, or radiochemotherapy. Chem Senses 40:165–171

    Article  CAS  PubMed  Google Scholar 

  • Pellegrino R, Hummel T (2020) Chemical, electrical and tactile sensitivity changes after middle ear surgery. Ann Otol Rhinol Laryngol 129:572–577

    Article  PubMed  Google Scholar 

  • Petty S, Salame C, Mennella JA, Pepino MY (2020) Relationship between sucrose taste detection thresholds and preferences in children, adolescents, and adults. Nutrients 12:1918

    Article  CAS  PubMed Central  Google Scholar 

  • Pingel J, Ostwald J, Pau HW, Hummel T, Just T (2010) Normative data for a solution-based taste test. Eur Arch Otorhinolaryngol 267:1911–1917

    Article  PubMed  Google Scholar 

  • Piochi M, Dinnella C, Prescott J, Monteleone E (2018) Associations between human fungiform papillae and responsiveness to oral stimuli: effects of individual variability, population characteristics, and methods for papillae quantification. Chem Senses 43:313–327

    Article  CAS  PubMed  Google Scholar 

  • Pribitkin E, Rosenthal MD, Cowart BJ (2003) Prevalence and causes of severe taste loss in a chemosensory clinic population. AnnOtol Rhinol Laryngol 112:971–978

    Article  Google Scholar 

  • Reiter ER, DiNardo LJ, Costanzo RM (2006) Toxic effects on gustatory function. Adv Otorhinolaryngol 63:265–277

    PubMed  Google Scholar 

  • Risso D, Drayna D, Morini G (2020) Alteration, reduction and taste loss: main causes and potential implications on dietary habits. Nutrients 12:3284

    Article  CAS  PubMed Central  Google Scholar 

  • Saito T, Yamada T, Okamoto M, Narita N (2012) Comparison of regeneration of the chorda tympani nerve and gustatory function recovery after severing the nerve between pediatric and adult patients. Otol Neurotol 33:1567–1572

    Article  PubMed  Google Scholar 

  • Saito T, Ito T, Ito Y, Manabe Y, Sano K (2016) Comparison of fungiform taste-bud distribution among age groups using confocal laser scanning microscopy in vivo in combination with gustatory function. Eur J Oral Sci 124:135–140

    Article  PubMed  Google Scholar 

  • Sakai F, Yoshida S, Endo S, Tomita H (2002) Double-blind, placebo-controlled trial of zinc picolinate for taste disorders. Acta Otolaryngol 122:129–133

    Article  Google Scholar 

  • Saluja S, Stevenson RJ (2018) Cross-modal associations between real tastes and colors. Chem Senses 43:475–480

    Article  CAS  PubMed  Google Scholar 

  • Schelling J-L, Tétreault L, Lasagna L, Davis M (1965) Abnormal taste threshold in diabetes. Lancet 285:508–511

    Article  Google Scholar 

  • Schiffman SS (1983) Taste and smell in disease. N Engl J Med 308:1337–1343

    Article  CAS  PubMed  Google Scholar 

  • Schneller LM, McIntosh S, Li D, Rahman I, Ossip D, Goniewicz M, O’Connor RJ (2018) Tobacco use and chemosensory impairments among current adult tobacco users in the US: data from NHANES 2013–2014. Tob Ind Dis 16:43

    Google Scholar 

  • Sergi G, Bano G, Pizzato S, Veronese N, Manzato E (2017) Taste loss in the elderly: possible implications for dietary habits. Crit Rev Food Sci Nutr 57:3684–3689

    Article  PubMed  Google Scholar 

  • Shah M, Deeb J, Fernando M, Noyce A, Visentin E, Findley LJ, Hawkes CH (2009) Abnormality of taste and smell in Parkinson’s disease. Parkinsonism Relat Disord 15:232–237

    Article  PubMed  Google Scholar 

  • Shi D, Qian JJ, Fan GH, Shen JK, Tian Y, Xu L (2019) Salivary gland function in nasopharyngeal carcinoma before and late after intensity-modulated radiotherapy evaluated by dynamic diffusion-weighted MR imaging with gustatory stimulation. BMC Oral Health 19:288

    Article  PubMed  PubMed Central  Google Scholar 

  • Shikata H, McMahon DB, Breslin PA (2000) Psychophysics of taste lateralization on anterior tongue. Percept Psychophys 62:684–694

    Article  CAS  PubMed  Google Scholar 

  • Sicchieri JMF, Peria FM, Sartorelli DS, Diez-Garcia RW (2019) Recognition of taste in patients during antineoplastic therapy with platinum drugs. Nutrition 67-68:110520

    Article  CAS  PubMed  Google Scholar 

  • Silva CS, Dias VR, Almeida JAR, Brazil JM, Santos RA, Milagres MP (2016) Effect of heavy consumption of alcoholic beverages on the perception of sweet and salty taste. Alcohol Alcohol 51:302–306

    Article  PubMed  Google Scholar 

  • Simon SA, de Araujo IE, Gutierrez R, Nicolelis MA (2006) The neural mechanisms of gustation: a distributed processing code. Nat Rev Neurosci 7:890–901

    Article  CAS  PubMed  Google Scholar 

  • Singh PB, Schuster B, Seo HS (2010) Variation in umami taste perception in the German and Norwegian population. Eur J Clin Nutr 64:1248–1250

    Article  CAS  PubMed  Google Scholar 

  • Singh Y, Gupta G, Satija S, Pabreja K, Chellappan DK, Dua K (2020) COVID-19 transmission through host cell directed network of GPCR. Drug Dev Res 81:647–649

    Article  CAS  PubMed  Google Scholar 

  • Smutzer G, Lam S, Hastings L, Desai H, Abarintos RA, Sobel M, Sayed N (2008) A test for measuring gustatory function. Laryngoscope 118:1411–1416

    Article  PubMed  PubMed Central  Google Scholar 

  • Snyder DJ, Sims CA, Bartoshuk LM (2015) Psychophysical measures of human oral sensation. In: Doty RL (ed) Handbook of olfaction and gustation, 3rd edn. Wiley, Philadelphia, pp 751–773

    Google Scholar 

  • Solomons N, Rosenberg I, Sandstead H, Vo-Khactu K (1977) Zinc deficiency in Crohn’s disease. Digestion 16:87–95

    Article  CAS  PubMed  Google Scholar 

  • Soter A, Kim J, Jackman A, Tourbier I, Kaul A, Doty RL (2008) Accuracy of self-report in detecting taste dysfunction. Laryngoscope 118:611–617

    Article  PubMed  Google Scholar 

  • Spielman AI, Pepino MY, Feldman R, Brand JG (2010) Technique to collect fungiform (taste) papillae from human tongue. J Vis Exp 42:2201

    Google Scholar 

  • Srur E, Stachs O, Guthoff R, Witt M, Pau HW, Just T (2010) Change of the human taste bud volume over time. Auris Nasus Larynx 37:449–455

    Article  PubMed  Google Scholar 

  • Srur E, Pau HW, Just T (2011) Changes in taste bud volume during taste disturbance. Auris Nasus Larynx 38:512–515

    Article  PubMed  Google Scholar 

  • Stillman JA, Morton RP, Hay KD, Ahmad Z, Goldsmith D (2003) Electrogustometry: strengths, weaknesses, and clinical evidence of stimulus boundaries. Clin Otolaryngol Allied Sci 28:406–410

    Article  CAS  PubMed  Google Scholar 

  • Stricker BH, Van Riemsdijk MM, Sturkenboom MC, Ottervanger JP (1996) Taste loss to terbinafine: a case-control study of potential risk factors. Br J Clin Pharmacol 42:313–318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Theys T, Kho KH, Siemons W, Thijs V (2009) A matter of taste. J Neurol Neurosurg Psychiatry 80:139–140

    Article  CAS  PubMed  Google Scholar 

  • Todrank J, Bartoshuk LM (1991) A taste illusion: taste sensation localized by touch. Physiol Behav 50:1027–1031

    Article  CAS  PubMed  Google Scholar 

  • Tomita H, Ikeda M (2002) Clinical use of electrogustometry: strengths and limitations. Acta Otolaryngol Suppl 546:27–38

    Article  Google Scholar 

  • Tomita H, Ikeda M, Okuda Y (1986) Basis and practice of clinical taste examinations. Auris Nasus Larynx 13(suppl. 1):S1–S15

    Article  PubMed  Google Scholar 

  • Treesukosol Y, Smith KR, Spector AC (2011) Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer in a mouse model. J Neurosci 31:13527–13534

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vennemann MM, Hummel T, Berger K (2008) The association between smoking and smell and taste impairment in the general population. J Neurol 255:1121–1126

    Article  PubMed  Google Scholar 

  • Veraldi S, Pontini P, Serini SL (2016) Terbinafine and taste loss. G Ital Dermatol Venereol 151:308–309

    PubMed  Google Scholar 

  • Walliczek-Dworschak U, Schops F, Feron G, Brignot H, Hahner A, Hummel T (2017) Differences in the density of fungiform papillae and composition of saliva in patients with taste disorders compared to healthy controls. Chem Senses 42:699–708

    Article  CAS  PubMed  Google Scholar 

  • Walliczek-Dworschak U, Knauer CM, Murbe D, Mainka A, Hummel T (2018) Analysis of taste function in patients before and after cochlear implant surgery. Rhinology 56:149–154

    Article  CAS  PubMed  Google Scholar 

  • Wallroth R, Ohla K (2018) As soon as you taste it: evidence for sequential and parallel processing of gustatory information. eNeuro 5:0269

    Article  Google Scholar 

  • Wang T, Glendinning J, Grushka M, Hummel T, Mansfield K (2017) From the cover: drug-induced taste disorders in clinical practice and preclinical safety evaluation. Toxicol Sci 156:315–324

    CAS  PubMed  Google Scholar 

  • Watson AB, Pelli DG (1983) QUEST: a Bayesian adaptive psychometric method. Percept Psychophys 33:113–120

    Article  CAS  PubMed  Google Scholar 

  • Weiffenbach JM, Cowart BJ, Baum BJ (1986) Taste intensity perception in aging. J Gerontol 41:460

    Article  CAS  PubMed  Google Scholar 

  • Weiland R, Macht M, Ellgring H, Gross-Lesch S, Lesch KP, Pauli P (2011) Olfactory and gustatory sensitivity in adults with attention-deficit/hyperactivity disorder. Atten Defic Hyperact Disord 3:53–60

    Article  PubMed  Google Scholar 

  • Welge-Luessen A, Leopold DA, Miwa T (2013) Smell and taste disorders – diagnostic and clinical work-up. In: Welge-Luessen A, Hummel T (eds) Management of smell and taste disorders – a practical guide for clinicians. Thieme, Stuttgart, pp 49–57

    Google Scholar 

  • Welge-Lussen A, Drago J, Wolfensberger M, Hummel T (2005) Gustatory stimulation influences the processing of intranasal stimuli. Brain Res 1038:69–75

    Article  PubMed  Google Scholar 

  • Welge-Lussen A, Husner A, Wolfensberger M, Hummel T (2009) Influence of simultaneous gustatory stimuli on orthonasal and retronasal olfaction. Neurosci Lett 454:124–128

    Article  PubMed  Google Scholar 

  • Welge-Lussen A, Dorig P, Wolfensberger M, Krone F, Hummel T (2011) A study about the frequency of taste disorders. J Neurol 258:386–392

    Article  PubMed  Google Scholar 

  • Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E, Potter C, Blendowski C (1999) Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 26:697

    CAS  PubMed  Google Scholar 

  • Wistehube T, Rullmann M, Wiacek C, Braun P, Pleger B (2018) Fat perception in the human frontal operculum, insular and somatosensory cortex. Sci Rep 8:11825

    Article  PubMed  PubMed Central  Google Scholar 

  • Xie P, Lefrançois P (2018) Efficacy, safety, and comparison of sonic hedgehog inhibitors in basal cell carcinomas: a systematic review and meta-analysis. J Am Acad Dermatol 79:1089–1100.e1017

    Article  CAS  PubMed  Google Scholar 

  • Xue Y, Wen Q, Xu C, Zhang X, Zeng J, Sha AM, Lan C, Li L, Wang H, Yang X (2020) Elevated salt taste threshold is associated with increased risk of coronary heart disease. J Cardiovasc Transl Res 13:1–8

    Article  Google Scholar 

  • Yoshida S, Endo S, Tomita H (1991) A double-blind study of the therapeutic efficacy of zinc gluconate on taste disorder. Auris Nasus Larynx 18:153–161

    Article  CAS  PubMed  Google Scholar 

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  1. Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden University Hospital, Dresden, Germany

    Y. Zhu & T. Hummel

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Zhu, Y., Hummel, T. (2021). Assessment of Taste Function. In: Palmer, R.K., Servant, G. (eds) The Pharmacology of Taste . Handbook of Experimental Pharmacology, vol 275. Springer, Cham. https://doi.org/10.1007/164_2021_471

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