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MicroRNAs in Kidney Diseases

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Biomarkers in Kidney Disease

Abstract

MicroRNAs (miRNAs) play an important role in physiological and pathological condition in human organs including kidneys. Their dysregulation on one hand can induce the onset of a specific disease and on the other hand may represent potential biomarkers for the diagnosis and therapy. In this chapter, the miRNA functions and modulations are described in several kidney diseases such as polycystic kidney disease, primary and secondary glomerulonephritides and renal transplantation. After the overview on the approach to identify and study miRNAs in nephrology, the miRNA meaning in renal physiology is illustrated. Also, the attractive perspectives of the use of miRNAs as diagnostic tools or for the specific treatment of kidney disease are taken into consideration.

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Abbreviations

AGO:

Argonaute

AKI:

Acute kidney injury

ANA:

Autoantibodies to nuclear antigen

ASO:

Antisense oligonucleotide

Bicc1:

Bicaudal C. homolog 1

CAMR:

Chronic antibody mediated rejection

Cdc25A:

Cell division cycle 25A

cDNA:

Complementary DNA

DGCR8:

RNA-binding protein DiGeorge syndrome critical region gene 8

DGF:

Delayed graft function

EMT:

Epithelial-to-mesenchymal transition

FPC:

Fibrocystin

GTP:

Guanosine triphosphate

HBEGF:

Heparin binding epidermal growth factor

HCV:

Hepatitis C virus

HIVAN:

HIV associated nephropathy

IF:

Interstitial fibrosis

IFN:

Interferon

IRAK1:

IL-1 receptor associated kinase1

IRI:

Ischemia-reperfusion injury

LN:

Lupus nephritis

miRNA:

MicroRNA

MRE:

MiRNA recognition elements

OREB:

Osmotic response element binding protein

PAZ:

Piwi-Argonaute-Zwille

PBMCs:

Peripheral blood mononuclear cells

PC:

Polycystin

PKD:

Polycystic kidney disease

pri-miRNA:

Primary miRNA transcript

RISC:

RNA-induced silencing complex

shRNA:

Small hairpin RNA

SLE:

Systemic lupus erythematosus

TA:

Tubular atrophy

TAL:

Thick ascending limb

TGF:

Transforming growth factor

TNF:

Tumor necrosis factor

TRAF6:

Tumor necrosis factor receptor-associated factor 6

TRBP:

Transactivator RNA binding protein

UTR:

Untranslated region

VEGF:

Vascular endothelial growth factor

VLP:

Virus like particles

WMLK:

With-no-lysine kinase

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Authors and Affiliations

  1. Laboratory of Experimental Immunopathology, IRCCS “de Bellis”, Strada Provinciale Turi, 27, 70013, Castellana Grotte, BA, Italy

    Grazia Serino

  2. Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy

    Fabio Sallustio & Francesco Paolo Schena

  3. C.A.R.S.O. Consortium, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy

    Francesco Paolo Schena

Authors
  1. Grazia Serino
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  2. Fabio Sallustio
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  3. Francesco Paolo Schena
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Correspondence to Francesco Paolo Schena .

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Editors and Affiliations

  1. DeptofBiomedlSci,FacltyofSci&Technology, University of Westminster , London, United Kingdom

    Vinood B. Patel

  2. Department of Nutrition and Dietetics,Division of Diabetes and Nutritional Sciences, Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Victor R. Preedy

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Serino, G., Sallustio, F., Schena, F.P. (2016). MicroRNAs in Kidney Diseases. In: Patel, V., Preedy, V. (eds) Biomarkers in Kidney Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7699-9_40

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