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Aging and Anti-Aging Strategies

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Textbook of Aging Skin

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Abstract

Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promotes wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes in cutaneous cells, we summarize, in this chapter, related mechanisms involved, discuss on potentential treatment until now disposable, and suggest preventive measures.

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References

  1. Caruso C, Passarino G, Puca A, Scapagnini G. “Positive biology”: the centenarian lesson. Immun Ageing. 2012;9:5.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW. Exceptional longevity does not result in excessive levels of disability. Proc Natl Acad Sci U S A. 2008;105:13274–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Hayflick L. Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both. PLoS Genet. 2007;3:e220.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Salminen A, Kaarniranta K. Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process. Ageing Res Rev. 2010;9:298–314.

    Article  CAS  PubMed  Google Scholar 

  5. Kirkwood TB, Holliday R. The evolution of ageing and longevity. Proc R Soc Lond B Biol Sci. 1979;205:531–46.

    Article  CAS  PubMed  Google Scholar 

  6. Kirkwood TB, Melov S. On the programmed/non-programmed nature of ageing within the life history. Curr Biol. 2011;21:R701–7.

    Article  CAS  PubMed  Google Scholar 

  7. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4–9.

    Article  PubMed  Google Scholar 

  8. Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing. 2005;2:8.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm. 2010;2010:1–19.

    Article  Google Scholar 

  10. Balistreri CR, Colonna-Romano G, Lio D, Candore G, Caruso C. TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. J Clin Immunol. 2009;29:406–15.

    Article  CAS  PubMed  Google Scholar 

  11. Candore G, Caruso C, Colonna-Romano G. Inflammation, genetic background and longevity. Biogerontology. 2010;11:565–73.

    Article  CAS  PubMed  Google Scholar 

  12. Balistreri CR, Candore G, Accardi G, Colonna-Romano G, Lio D. NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies. Immun Ageing. 2013;10:24.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal. 2012;24:835–45.

    Article  CAS  PubMed  Google Scholar 

  14. Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest. 2013;123:966–72.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Gilmore TD, Wolenski FS. NF-κB: where did it come from and why? Immunol Rev. 2012;246:14–35.

    Article  PubMed  Google Scholar 

  16. Newton K, Dixit VM. Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol. 2012;4:1–19.

    Article  Google Scholar 

  17. Rattan SI. Theories of biological aging: genes, proteins, and free radicals. Free Radic Res. 2006;40:1230–8.

    Article  CAS  PubMed  Google Scholar 

  18. Yaar M, Gilchrest BA. Photoageing: mechanism, prevention and therapy. Br J Dermatol. 2007;157:874–87.

    Article  CAS  PubMed  Google Scholar 

  19. Zouboulis CC, Makrantonaki E. Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol. 2011;29:3–14.

    Article  PubMed  Google Scholar 

  20. Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008;17:1063–72.

    Article  PubMed  Google Scholar 

  21. Farage MA, Miller KW, Elsner P, Maibach HI. Characteristics of the Aging Skin. Adv Wound Care (New Rochelle). 2013;2(1):5–10.

    Article  Google Scholar 

  22. Naylor EC, Watson RE, Sherratt MJ. Molecular aspects of skin ageing. Maturitas. 2011;69:249–56.

    Article  CAS  PubMed  Google Scholar 

  23. Zhuang Y, Lyga J. Inflammaging in skin and other tissues – the roles of complement system and macrophage. Inflamm Allergy Drug Targets. 2014;13:153–61.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–97.

    Article  CAS  PubMed  Google Scholar 

  25. Mancini M, Lena AM, Saintigny G, Mahé C, Di Daniele N, Melino G, Candi E. MicroRNAs in human skin ageing. Ageing Res Rev. 2014;17:9–15.

    Article  CAS  PubMed  Google Scholar 

  26. Shin KH, Pucar A, Kim RH, Bae SD, Chen W, Kang MK, Park NH. Identification of senescence-inducing microRNAs in normal human keratinocytes. Int J Oncol. 2011;39:1205–11.

    PubMed Central  CAS  PubMed  Google Scholar 

  27. Rivetti di Val Cervo P, Lena AM, Nicoloso M, Rossi S, Mancini M, Zhou H, Saintigny G, Dellambra E, Odorisio T, Mahé C, Calin GA, Candi E, Melino G. p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A. 2012;109:1133–8.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Donmez G, Guarente L. Aging and disease: connections to sirtuins. Aging Cell. 2010;9:285–90.

    Article  CAS  PubMed  Google Scholar 

  29. Kafi R, Kwak HSR, Schumacher WE, et al. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007;143:606–12.

    Article  CAS  PubMed  Google Scholar 

  30. Baumann L. Skin ageing and its treatment. J Pathol. 2007;211:241–51.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathobiology and Medical Biotechnologies, University of Palermo, Immunosenescence Unit, Palermo, Italy

    Carmela Rita Balistreri, Giuseppina Candore & Calogero Caruso

  2. Department of Health Sciences, University of Molise, Campobasso, Italy

    Giovanni Scapagnini

Authors
  1. Carmela Rita Balistreri
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  2. Giuseppina Candore
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  3. Giovanni Scapagnini
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  4. Calogero Caruso
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Corresponding author

Correspondence to Carmela Rita Balistreri .

Editor information

Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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© 2015 Springer-Verlag Berlin Heidelberg

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Balistreri, C.R., Candore, G., Scapagnini, G., Caruso, C. (2015). Aging and Anti-Aging Strategies. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_97-2

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_97-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27814-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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