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Holographic Optical Coherence Imaging

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Optical Coherence Tomography

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Abstract

This chapter gives an overview of the principles of holographic OCI. It begins with a description of off-axis holography as spatial heterodyne detection and continues with the origin and role of speckle in multichannel illumination of tissue. Image-domain holography (IDH) and Fourier-domain holography (FDH) are described. Holography in the Fourier domain has the capability for phase-contrast imaging that can acquire small sub-wavelength displacements despite long coherence length. The trade-offs between photorefractive and digital holography are discussed. The chief biological target is multicellular spheroids, specifically rat osteogenic sarcomas that are grown in vitro. After describing the physiological and optical properties of these spheroids, results from holographic OCI are presented using both photorefractive and digital holography.

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Acknowledgements

The authors gratefully acknowledge support from NSF1263753-CBET and NIH NIBIB 1R01EB016582-01.

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Authors and Affiliations

  1. Department of Physics, Purdue University, West Lafayette, IN, USA

    David D. Nolte

  2. Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA

    David D. Nolte & John Turek

  3. Imperial College, London, UK

    Paul M. W. French

  4. Physics Department, Korean Military Academy, Soeul, South Korea

    Kwan Jeong

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  1. David D. Nolte
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Correspondence to David D. Nolte .

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Editors and Affiliations

  1. Center for Medical Physics and Biomedical Engineering, Medical University Vienna, General Hospital Vienna, Vienna, Austria

    Wolfgang Drexler

  2. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    James G. Fujimoto

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Nolte, D.D., Jeong, K., Turek, J., French, P.M.W. (2015). Holographic Optical Coherence Imaging. In: Drexler, W., Fujimoto, J. (eds) Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-06419-2_31

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