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Difficult Biliary Cannulation and Sphincterotomy: What to Do

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Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy

Abstract

Endoscopic retrograde cholangiopancreatography (ERCP) is a complex and invasive procedure that is associated with adverse events including pancreatitis, bleeding, infection, perforation, cardiopulmonary complications, and rarely death. Technical success of this procedure relies on accessing the bile (and/or pancreatic) duct and being able to perform sphincterotomy safely. Standard cannulation methods are successful in the majority of cases; however, there are times when difficult biliary cannulation is encountered. In this setting advanced techniques for completion are required. Methods for biliary access include double guidewire technique, precut sphincterotomy, transpancreatic sphincterotomy, and others (endoscopic ultrasound or percutaneous transhepatic guided biliary drainage). In this chapter, we aim to review the standard and advanced techniques for biliary cannulation, predictors of difficult cannulation and methods for performing biliary sphincterotomy.

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References

  1. McCune WS et al (1968) Endoscopic cannulation of the ampulla of vater: a preliminary report. Ann Surg 167(5):752–756

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Moffatt DC et al (2014) Trends in utilization of diagnostic and therapeutic ERCP and cholecystectomy over the past 25 years: a population-based study. Gastrointest Endosc 79(4):615–622

    Article  PubMed  Google Scholar 

  3. Adler DG et al (2005) ASGE guideline: the role of ERCP in diseases of the biliary tract and the pancreas. Gastrointest Endosc 62(1):1–8

    Article  PubMed  Google Scholar 

  4. Loperfido S et al (1998) Major early complications from diagnostic and therapeutic ERCP : a prospective multicenter study. Gastrointest Endosc 48(1):1–10

    Article  CAS  PubMed  Google Scholar 

  5. Freeman ML (2012) Complications of endoscopic retrograde cholangiopancreatography: avoidance and management. Gastrointest Endosc Clin N Am 22(3):567–586

    Article  PubMed  Google Scholar 

  6. Freeman ML et al (2001) Risk factors for post-ERCP pancreatitis: a prospective, multicenter study. Gastrointest Endosc 54(4):425–434

    Article  CAS  PubMed  Google Scholar 

  7. Williams EJ et al (2007) Risk factors for complication following ERCP; results of a large-scale, prospective multicenter study. Endoscopy 39(9):793–801

    Article  CAS  PubMed  Google Scholar 

  8. Freeman ML (2002) Adverse outcomes of ERCP. Gastrointest Endosc 56(6 Suppl):S273–S282

    Article  PubMed  Google Scholar 

  9. Testoni PA et al (2010) Risk factors for post-ERCP pancreatitis in high- and low-volume centers and among expert and non-expert operators: a prospective multicenter study. Am J Gastroenterol 105(8):1753–1761

    Article  PubMed  Google Scholar 

  10. Liao WC et al (2017) International consensus recommendations for difficult biliary access. Gastrointest Endosc 85(2):295–304

    Article  PubMed  Google Scholar 

  11. Halttunen J et al (2014) Difficult cannulation as defined by a prospective study of the Scandinavian Association for Digestive Endoscopy (SADE) in 907 ERCPs. Scand J Gastroenterol 49(6):752–758

    Article  PubMed  Google Scholar 

  12. Testoni PA et al (2016) Papillary cannulation and sphincterotomy techniques at ERCP: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy 48(7):657–683

    Article  PubMed  Google Scholar 

  13. Ismail S et al (2019) Criteria for difficult biliary cannulation: start to count. Eur J Gastroenterol Hepatol 31(10):1200–1205

    Article  PubMed  Google Scholar 

  14. Jowell PS et al (1996) Quantitative assessment of procedural competence. A prospective study of training in endoscopic retrograde cholangiopancreatography. Ann Intern Med 125:983–989

    Article  CAS  PubMed  Google Scholar 

  15. Ekkelenkamp VE et al (2014) Competence development in ERCP: the learning curve of novice trainees. Endoscopy 46:969–955

    Google Scholar 

  16. Verma D et al (2007) Establishing a true assessment of endoscopic competence in ERCP during training and beyond: a single-operator learning curve for deep biliary cannulation in patients with native papillary anatomy. Gastrointest Endosc 65:394–400

    Article  PubMed  Google Scholar 

  17. Wani S et al (2016) Variation in learning curves and competence for ERCP among advanced endoscopy trainees by using cumulative sum analysis. Gastrointest Endosc 83(4):711–719.e11

    Article  PubMed  Google Scholar 

  18. Cortas GA et al (1999) Selective cannulation of the common bile duct: a prospective randomized trial comparing standard catheters with sphincterotomes. Gastrointest Endosc 50:775–779

    Article  CAS  PubMed  Google Scholar 

  19. Schwacha H et al (2000) A sphincterotome-based technique for selective transpapillary common bile duct cannulation. Gastrointest Endosc 52:387–391

    Article  CAS  PubMed  Google Scholar 

  20. Laasch HU et al (2003) Comparison of standard and steerable catheters for bile duct cannulation in ERCP. Endoscopy 35:669–674

    Article  PubMed  Google Scholar 

  21. Karamanolis G et al (2005) A prospective cross-over study using a sphincterotome and a guidewire to increase the success rate of common bile duct cannulation. World J Gastroenterol 11:1649–1652

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kitamura K et al (2015) 0.025-inch vs 0.035-inch guide wires for wire-guided cannulation during endoscopic retrograde cholangiopancreatography: a randomized study. World J Gastroenterol 21(30): 9182–9189188

    Google Scholar 

  23. Vihervaara H et al (2013) Angled- or straight-tipped hydrophilic guidewire in biliary cannulation: a prospective, randomized, controlled trial. Surg Endosc 27:1281–1286

    Article  PubMed  Google Scholar 

  24. TsuchiyaT et al (2015) J-Tip guidewire for selective biliary cannulation compared to conventional guidewires (the JANGLE study). Dig Dis Sci 60:2502–2508

    Article  Google Scholar 

  25. Cheung J et al (2009) Guidewire versus conventional contrast cannulation of the common bile duct for the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis. Gastrointest Endosc 70:1211–1229

    Article  PubMed  Google Scholar 

  26. Tse F et al (2013) Guidewire-assisted cannulation for the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis. Endoscopy 45:605–618

    Article  CAS  PubMed  Google Scholar 

  27. Shao LM et al (2009) Can wire-guided cannulation reduce the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis? A meta-analysis of randomized controlled trials. J Gastroenterol Hepatol 24:1710–1715

    Article  PubMed  Google Scholar 

  28. Herreros de Tejada A et al (2009) Double-guidewire technique for difficult bile duct cannulation: a multicenter randomized, controlled trial. Gastrointest Endosc 70:700–709

    Article  PubMed  Google Scholar 

  29. Angsuwatcharakon P et al (2012) Success rate and cannulation time between precut sphincterotomy and double-guidewire technique in truly difficult biliary cannulation. J Gastroenterol Hepatol 27:356–3561

    Article  PubMed  Google Scholar 

  30. Coté GA et al (2012) Use of a pancreatic duct stent or guidewire facilitates bile duct access with low rates of precut sphincterotomy: a randomized clinical trial. Dig Dis Sci 57:3271–3278

    Article  PubMed  Google Scholar 

  31. Maeda S et al (2003) Prospective randomized pilot trial of selective biliary cannulation using pancreatic guide-wire placement. Endoscopy 35:721–724

    Article  CAS  PubMed  Google Scholar 

  32. Yoo YW et al (2013) Double guidewire technique vs transpancreatic precut sphincterotomy in difficult biliary cannulation. World J Gastroenterol 19:108–114

    Article  PubMed  PubMed Central  Google Scholar 

  33. Ito K et al (2010) Can pancreatic duct stenting prevent postERCP pancreatitis in patients who undergo pancreatic duct guidewire placement for achieving selective biliary cannulation? A prospective randomized controlled trial. J Gastroenterol 45:1183–1191

    Article  PubMed  Google Scholar 

  34. Ito K et al (2014) Clinical usefulness of double-guidewire technique for difficult biliary cannulation in endoscopic retrograde cholangiopancreatography. Dig Endosc 26:442–449

    Article  PubMed  Google Scholar 

  35. Navaneethan U et al (2014) Early precut sphincterotomy and the risk of endoscopic retrograde cholangio-pancreatography related complications: an updated meta-analysis. World J Gastro-intest Endosc 6:200–208

    Article  Google Scholar 

  36. Choudhary A et al (2014) Effect of precut sphincterotomy on post-endoscopic retrograde cholangio-pancreatography pancreatitis: a systematic review and meta-analysis. World J Gastroenterol 20:4093–4101

    Article  PubMed  PubMed Central  Google Scholar 

  37. Mavrogiannis C et al (1999) Needle-knife fistulotomy versus needle-knife papillotomy for the treatment of common bile duct stones. Gastrointest Endosc 50:334–339

    Article  CAS  PubMed  Google Scholar 

  38. Katsinelos P et al (2012) Comparison of three types of precut technique to achieve common bile duct cannulation: a retrospective analysis of 274 cases. Dig Dis Sci 57:3286–3292

    Article  PubMed  Google Scholar 

  39. Zang J et al (2014) Guidewire-assisted transpancreatic sphincterotomy for difficult biliary cannulation: a prospective randomized con- trolled trial. Surg Laparosc Endosc Percutan Tech 24:429–433

    Article  PubMed  Google Scholar 

  40. Chun CG et al (2012) DGT vs. TPS in patients with initial PD cannulation by chance: prospective randomized multicenter study. Gastrointest Endosc 75:–AB141

    Google Scholar 

  41. Catalano MF et al (2004) Endoscopic transpancreatic papillary septotomy for inaccessible obstructed bile ducts: comparison with standard pre-cut papillotomy. Gastrointest Endosc 60:557–561

    Article  PubMed  Google Scholar 

  42. Kahaleh M et al (2004) Prospective evaluation of pancreatic sphincterotomy as a precut technique for biliary cannulation. Clin Gastroenterol Hepatol 2:971–977

    Article  PubMed  Google Scholar 

  43. Lee YJ et al (2015) Different strategies for transpancreatic septotomy and needle knife infundibulotomy due to the presence of unintended pancreatic cannulation in difficult biliary cannulation. Gut Liver 9:534–539

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Halttunen J et al (2009) Pancreatic sphincterotomy versus needle knife precut in difficult biliary cannulation. Surg Endosc 23:745–749

    Article  PubMed  Google Scholar 

  45. Wang P et al (2010) Success and complication rates of two pre- cut techniques, transpancreatic sphincterotomy and needle-knife sphincterotomy for bile duct cannulation. J Gastrointest Surg 14:697–704

    Article  PubMed  Google Scholar 

  46. Kim J et al (2012) Results of repeat endoscopic retrograde cholangiopancreatography after initial biliary cannulation failure following needle-knife sphincterotomy. J Gastroenterol Hepatol 27:516–520

    Article  PubMed  Google Scholar 

  47. Burdick JS et al (2002) Intramural incision technique. Gastrointest Endosc 55:425–427

    Article  PubMed  Google Scholar 

  48. Misra SP, Dwivedi M (2008) Intramural incision technique: a useful and safe procedure for obtaining ductal access during ERCP. Gastrointest Endosc 67:629–633

    Article  PubMed  Google Scholar 

  49. Thomas R et al (2009) Biliary access in technically difficult biliary cannulation: the mucosal bridge technique. HPB (Oxford) 11:176–180

    Article  Google Scholar 

  50. Geonke MK, Rai VK (2015) Burdick’s technique for biliary access revisited. Clin Endoscopy 48(1):20–23

    Article  Google Scholar 

  51. Boix J et al (2006) Impact of periampullary duodenal diverticula at endoscopic retrograde cholangiopancreatography: a proposed classification of periampullary duodenal diverticula. Surg Laparosc Endosc Percutan Tech 16:208–211

    Article  PubMed  Google Scholar 

  52. Elmunzer BJ, Boetticher NC (2015) Reverse guidewire anchoring of the papilla for difficult cannulation due to a periampullary diverticulum. Gastrointest Endosc 82:957

    Article  PubMed  Google Scholar 

  53. Huang CH et al (2010) Endoscopic retrograde cholangiopancreatography (ERCP) for intradiverticular papilla: endoclip-assisted biliary cannulation. Endoscopy 42(Suppl 2):E223–E224

    Article  PubMed  Google Scholar 

  54. Fujita N et al (1998) ERCP for intradiverticular papilla: two-devices-in-one-channel method. Endoscopic retrograde Cholangiopancreatography. Gastrointest Endosc 48:517–520

    Article  CAS  PubMed  Google Scholar 

  55. Tóth E et al (1999) An alternative approach to the inaccessible intradiverticular papilla. Endoscopy 31:554–556

    Article  PubMed  Google Scholar 

  56. Myung DS et al (2014) Cap-assisted ERCP in patients with difficult cannulation due to periampullary diverticulum. Endoscopy 46:352–355

    Article  PubMed  Google Scholar 

  57. Külling D, Haskell E (2005) Double endoscope method to access intradiverticular papilla. Gastrointest Endosc 62:811–812

    Article  PubMed  Google Scholar 

  58. Leng J-J et al (2014) Percutaneous transhepatic and endoscopic biliary drainage for malignant biliary tract obstruction: a meta-analysis. World J Surgical Oncol 12:272

    Article  Google Scholar 

  59. Kawai K et al (1974) Endoscopic sphincterotomy of the ampulla of Vater. Gastrointest Endosc 20(4):148–151

    Article  CAS  PubMed  Google Scholar 

  60. Classen M, Demling L (1974) Endoscopic sphincterotomy of the papilla of vater and extraction of stones from the choledochal duct (author's transl). Dtsch MedWochenschr 99(11):496–497. German

    Article  CAS  Google Scholar 

  61. Raymondos K et al (2002) Evaluation of endoscopic retrograde cholangiopancreatography under conscious sedation and general anesthesia. Endoscopy 34(9):721–726. PubMed PMID: 12195330

    Article  CAS  PubMed  Google Scholar 

  62. Behrens A et al (2018) Acute sedation-associated complications in GI endoscopy (ProSed 2 study) results from the prospective multicentre electronic registry of sedation-associated complications. Gut 3. pii: gutjnl-2015-gutjn311037. https://doi.org/10.1136/gutjnl-2015-311037

  63. Wang D et al (2013) The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. PLoS One 8(1):e53311. https://doi.org/10.1371/journal.pone.0053311. Epub 2013 Jan 8. PubMed PMID: 23308191; PubMed Central PMCID: PMC3540096

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Petersen BT et al (2007) Technology assessment committee. Endoscopy in patients with implanted electronic devices. Gastrointest Endosc 65(4):561–568. Review. PubMed PMID: 17383453

    Article  PubMed  Google Scholar 

  65. Veitch AM et al (2016) Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines. Endoscopy 48(4):c1. https://doi.org/10.1055/s-0042-122686

    Article  PubMed  Google Scholar 

  66. Verma D et al (2007) Pure versus mixed electrosurgical current for endoscopic biliary sphincterotomy: a meta-analysis of adverse outcomes. Gastrointest Endosc 66(2):283–290. Review

    Article  PubMed  Google Scholar 

  67. Ryozawa S et al (2018) Japan gastroenterological endoscopy society guidelines for endoscopic sphincterotomy. Dig Endosc 30(2):149–173. https://doi.org/10.1111/den.13001. Epub 2018 Jan 18

    Article  PubMed  Google Scholar 

  68. Mirjalili SA, Stringer MD (2011) The arterial supply of the major duodenal papilla and its relevance to endoscopic sphincterotomy. Endoscopy 43(4):307–311. https://doi.org/10.1055/s-0030-1256229. Epub 2011 Mar 31

    Article  CAS  PubMed  Google Scholar 

  69. Leung JW et al (1990) Precut (needle knife) papillotomy for impacted common bile duct stone at the ampulla. Am J Gastroenterol 85(8):991–993

    CAS  PubMed  Google Scholar 

  70. Joo KR et al (2010) Case review of impacted bile duct stone at duodenal papilla: detection and endoscopic treatment. Yonsei Med J 51(4):534–539. https://doi.org/10.3349/ymj.2010.51.4.534

    Article  PubMed  PubMed Central  Google Scholar 

  71. Park DH et al (2006) A novel method for estimating the safe margin and the adequate direction of endoscopic biliary sphincterotomy in choledocholithiasis with complications (with videos). Gastrointest Endosc 64(6):979–983

    Article  PubMed  Google Scholar 

  72. Siegel JH et al (1994) Stent-guided sphincterotomy. Gastrointest Endosc 40(5):567–572

    Article  CAS  PubMed  Google Scholar 

  73. Mavrogiannis C et al (2003) Safety of extension of a previous endoscopic sphincterotomy: a prospective study. Am J Gastroenterol 98(1):72–76

    Article  PubMed  Google Scholar 

  74. Ersoz G et al (2003) Biliary sphincterotomy plus dilation with a large balloon for bile duct stones that are difficult to extract. Gastrointest Endosc 57(2):156–159

    Article  PubMed  Google Scholar 

  75. Heo JH et al (2007) Endoscopic sphincterotomy plus large-balloon dilation versus endoscopic sphincterotomy for removal of bile-duct stones. Gastrointest Endosc 66(4):720–726. quiz 768, 771

    Article  PubMed  Google Scholar 

  76. Liao WC et al (2012) Balloon dilation with adequate duration is safer than sphincterotomy for extracting bile duct stones: a systematic review and meta-analyses. Clin Gastroenterol Hepatol 10(10):1101–1109. https://doi.org/10.1016/j.cgh.2012.05.017. Epub 2012 May 27

    Article  PubMed  Google Scholar 

  77. Zhao HC et al (2013) Meta-analysis comparison of endoscopic papillary balloon dilatation and endoscopic sphincteropapillotomy. World J Gastroenterol 28(19):24.):3883-91. https://doi.org/10.3748/wjg.v19.i24.3883.

    Article  CAS  Google Scholar 

  78. Cochrane J, Schlepp G (2016) Comparing endoscopic intervention against fully covered self-expanding metal stent placement for post-endoscopic sphincterotomy bleed (CEASE study). Endosc Int Open 4(12):E1261–E1264. Epub 2016 Nov 24

    Article  PubMed  PubMed Central  Google Scholar 

  79. Canard JM, Lennon AM, Letard J et al. (2011) Endoscopic retrograde cholangiopancreatography. In: Canard JM (ed) Gastrointestinal Endoscopy in Practice. Churchill Livingstone, London, p370-465

    Google Scholar 

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Williams, E.J., Krishnan, B., Lau, S.Y. (2021). Difficult Biliary Cannulation and Sphincterotomy: What to Do. In: Testoni, P.A., Inoue, H., Wallace, M.B. (eds) Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-29964-4_65-2

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  • DOI: https://doi.org/10.1007/978-3-030-29964-4_65-2

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Chapter history

  1. Latest

    Difficult Biliary Cannulation and Sphincterotomy: What to Do
    Published:
    10 August 2021

    DOI: https://doi.org/10.1007/978-3-030-29964-4_65-2

  2. Original

    Difficult Biliary Cannulation and Sphinterotomy: What to Do
    Published:
    09 June 2021

    DOI: https://doi.org/10.1007/978-3-030-29964-4_65-1