Abstract
Tryptamine (T) and 2-phenylethylamine (PE) can be formed in vivo by the decarboxylation of the precursor amino acids L-tryptophan and L-phenylalanine, respectively. As would be expected of immediate products of amino acid decarboxylation, both of these amines are phylogenetically very old. They have been detected in invertebrate, as well as mammalian, nervous systems (see Boulton and Juorio, 1982, for review). These amines can be synthesized locally by mammalian brain (Saavedra and Axelrod, 1973; Snodgrass and Horn, 1973; Snodgrass, 1974), and because they cross the blood-brain barrier, they can enter the brain from the circulation (Marsden and Curzon, 1978; Randrup and Munkvad, 1966). Both T and PE have effects in the CNS after systemic injection.
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Kellar, K.J., Cascio, C.S. (1986). Tryptamine and Phenylethylamine Recognition Sites in Brain. In: Boulton, A.A., Baker, G.B., Hrdina, P.D. (eds) Receptor Binding. Neuromethods, vol 4. Humana Press. https://doi.org/10.1385/0-89603-078-4:119
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DOI: https://doi.org/10.1385/0-89603-078-4:119
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