Abstract
Electrospinning is a useful technique for generating scaffolds composed of nano- and/or microfibers. Through an innovative modification of the cylindrical target mandrel it is possible to create macrostructural or microstructural invaginations. The former provides complex bulk mechanical behavior reminiscent of native soft tissue; the latter leads to a surface topography reminiscent of intestinal villi.
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References
Cooley FJ (1902) US patent no. 692,631
Morton WJ (1902) US patent no. 705,691
Doshi J, Reneker DH (1995) Electrospinning process and applications of electrospun fibers. J Electrostat 35:151–160
Bhardwaj N, Kundu SC (2010) Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv 28:325–347
Jiang H, Hu Y, Li Y, Zhao P, Zhu K, Chen W (2005) A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents. J Control Release 108(2–3):237–243
Aviss KJ, Gough JE, Downes S (2010) Aligned electrospun polymer fibres for skeletal muscle regeneration. Eur Cell Mater 19:193–204
Townsend-Nicholson A, Jayasinghe SN (2006) Cell electrospinning: a unique biotechnique for encapsulating living organisms for generating active biological microthreads/scaffolds. Biomacromolecules 7(12):3364–3369
Rapoport HS, Fish J, Basu J, Campbell J, Genheimer C, Payne R, Jain D (2012) construction of a tubular scaffold that mimics J-shaped stress/strain mechanics using an innovative electrospinning technique. Tissue Eng Part C Methods. Epub ahead of print PMID: 22250785
Soletti L, Hong Y, Guan K, Stankus JJ, El-Kurdi MS, Wagner WR, Vorp DA (2010) A bilayered elastomeric scaffold for tissue engineering of small diameter vascular grafts. Acta Biomater 6(1):110–122
Zhu C, Fan D, Duan Z, Xue W, Shang Lm Chen F, Luo Y (2009) Initial investigation of novel human-like collagen/chitosan scaffold for vascular tissue engineering. J Biomed Res A 89(3):829–840
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Rapoport, S. (2013). Electrospinning Tubular Scaffolds with Tissue-Like Mechanical Properties and Biomimetic Surface Features. In: Basu, J., Ludlow, J. (eds) Organ Regeneration. Methods in Molecular Biology, vol 1001. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-363-3_13
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DOI: https://doi.org/10.1007/978-1-62703-363-3_13
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-362-6
Online ISBN: 978-1-62703-363-3
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